Toni Wilen continue d'améliorer le fonctionnement de strongWinUAE/strong, émulateur strongAmiga/strong sur Windows. Parmi les changements, on note que l'écran titre du shoot them up Disposable Hero est maintenant parfaitement affiché.br / br / p class="center"a href="http://www.emunova.net/img/actu/bd3558907eac045e05ae316daf213f74.png" rel="gallery"img src="http://www.emunova.net/img/actu/bd3558907eac045e05ae316daf213f74.png" style="width: 400px; height: 320px" alt="" //a/pbr / blockquote- Erreurs HAM si la bordure gauche n'était pas complètement visible (il semble que ce bogue a toujours été présent depuis le début de UAE, le code qui devait gérer ce cas n'a jamais fonctionner correctement).br / - Correction du changement HAM/EHB/DPF à mi-ligne horizontale (Cover Girl Strip Poker), cassé depuis la version 1.5.3.br / - Ajout de win32.guikey au fichier de configuration, touche raccourci qui ouvre l'interface graphique (touche raccourci directimput, par exemple F10 = 0x44), -1 = par défaut.br / - Le paramètre none-setting pour les ports IO et jeu fonctionne proprement.br / - Le créateur de VHD ne créait pas des images complètement compatibles (les images trop grosses n'étaient pas compatibles avec les outils officiels VHD, cela causait des corruptions de données).br / - Emulation du truc "1st Anniversary" par Lazy Bones OCS/ECS "7-planes" (lignes noires verticales manquantes).br / - L'écran titre de Disposable Hero est maintenant parfait.br / - Ajout de quelques tests pour vérifier la santé de la gestion de la couche DirectDraw./blockquote pa href="http://feeds.feedburner.com/~a/emunovaNews?a=i64lOO"img src="http://feeds.feedburner.com/~a/emunovaNews?i=i64lOO" border="0"/img/a/pdiv class="feedflare" a href="http://feeds.feedburner.com/~f/emunovaNews?a=nho7N"img src="http://feeds.feedburner.com/~f/emunovaNews?i=nho7N" border="0"/img/a a href="http://feeds.feedburner.com/~f/emunovaNews?a=yGThN"img src="http://feeds.feedburner.com/~f/emunovaNews?i=yGThN" border="0"/img/a a href="http://feeds.feedburner.com/~f/emunovaNews?a=KVjEN"img src="http://feeds.feedburner.com/~f/emunovaNews?i=KVjEN" border="0"/img/a a href="http://feeds.feedburner.com/~f/emunovaNews?a=pZfiN"img src="http://feeds.feedburner.com/~f/emunovaNews?i=pZfiN" border="0"/img/a a href="http://feeds.feedburner.com/~f/emunovaNews?a=ktoon"img src="http://feeds.feedburner.com/~f/emunovaNews?i=ktoon" border="0"/img/a /divimg src="http://feeds.feedburner.com/~r/emunovaNews/~4/470396123" height="1" width="1"/

Une nouvelle version beta de cet émulateur Amiga pour Windows vient d'être publiée. Les améliorations sont les suivantes:
- HAM errors if left border was not fully visible (it seems this bug has been there since the beginning of UAE, code that was supposed to handle this case has never worked correctly..)
- mid horizontal line HAM/EHB/DPF change fixed (Cover Girl Strip Poker) broke in 1.5.3
- added win32.guikey to configuration file, keycode that opens GUI (raw directinput keycode, for example F10 = 0x44) -1 = default.
- game & io-ports -setting works properly
- vhd creator didn't create fully compatible images (larger images were incompatible with official vhd tools, did not cause data corruption)
- 1st Anniversary by Lazy Bones OCS/ECS "7-planes" trick emulated (missing black vertical lines)
- Disposable Hero title screen is now perfect. Take screenshots before it gets broken again
- added some more sanity tests to DirectDraw surface handlingTélécharger WinUAE v1.5.4 beta 3Site Officiel de WinUAE

Une version Beta public de l'excellent WinUAE. - HAM errors if left border was not fully visible (it seems this bug has been there since the beginning of UAE, code that was supposed to handle this case has never worked correctly..) - mid horizontal line HAM/EHB/DPF change fixed (Cover Girl Strip Poker) broke in 1.5.3 - added win32.guikey to configuration file, keycode that opens GUI (raw directinput keycode, for example F10 = 0x44) -1 = default. - game io-ports none-setting works properly - vhd creator didn't create fully compatible images (larger images were incompatible with official vhd tools, did not cause data corruption) - 1st Anniversary by Lazy Bones OCS/ECS 7-planes trick emulated (missing black vertical lines) - Disposable Hero title screen is now perfect. Take screenshots before it gets broken again - added some more sanity tests to DirectDraw surface handling

Publication Date: 2008 Nov 12 PMID: 19038268br/Authors: Silverman, A. P. - Levin, A. M. - Lahti, J. L. - Cochran, J. R.br/Journal: J Mol Biolbr/br/The alpha(v)beta(3) integrin receptor is an important cancer target due to its overexpression on many solid tumors and the tumor neovasculature and its role in metastasis and angiogenesis. We used a truncated form of the Agouti-related protein (AgRP), a 4-kDa cystine-knot peptide with four disulfide bonds and four solvent-exposed loops, as a scaffold for engineering peptides that bound to alpha(v)beta(3) integrins with high affinity and specificity. A yeast-displayed cystine-knot peptide library was generated by substituting a six-amino-acid loop of AgRP with a nine-amino-acid loop containing the Arg-Gly-Asp integrin recognition motif and randomized flanking residues. Mutant cystine-knot peptides were screened in a high-throughput manner by fluorescence-activated cell sorting to identify clones with high affinity to detergent-solubilized alpha(v)beta(3) integrin receptor. Select integrin-binding peptides were expressed recombinantly in Pichia pastoris and were tested for their ability to bind to human cancer cells expressing various integrin receptors. These studies showed that the engineered AgRP peptides bound to cells expressing alpha(v)beta(3) integrins with affinities ranging from 15 nM to 780 pM. Furthermore, the engineered peptides were shown to bind specifically to alpha(v)beta(3) integrins and had only minimal or no binding to alpha(v)beta(5), alpha(5)beta(1), and alpha(iib)beta(3) integrins. The engineered AgRP peptides were also shown to inhibit cell adhesion to the extracellular matrix protein vitronectin, which is a naturally occurring ligand for alpha(v)beta(3) and other integrins. Next, to evaluate whether the other three loops of AgRP could modulate integrin specificity, we made second-generation libraries by individually randomizing these loops in one of the high-affinity integrin-binding variants. Screening of these loop-randomized libraries against alpha(v)beta(3) integrins resulted in peptides that retained high affinities for alpha(v)beta(3) and had increased specificities for alpha(v)beta(3) over alpha(iib)beta(3) integrins. Collectively, these data validate AgRP as a scaffold for protein engineering and demonstrate that modification of a single loop can lead to AgRP-based peptides with antibody-like affinities for their target.br/br/post to: a href = http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19038268title=Entrez+PubmedCiteULike/a