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TorrentFreak -
1 days ago
Despite protest from the public, the UK Government continues to push forward with the adoption of
the Digital Economy Bill (DEB), legislation that will supposedly protect copyright holders from
online pirates.
This week the House of Lords approved the Bill and handed it over to the House of Commons who
will deal with the most controversial elements – disconnections and site-blocking –
without proper scrutiny during the so-called “wash-up” period.
This and other controversies have absolutely enraged those who oppose the Bill and has led more
than 10,000 voters in the last few days to write to their MPs to demand a full
debate.
Last night, musician Billy Bragg, TalkTalk’s Andrew Heaney, Jim Killock from the Open
Rights Group and Anthony Barnett from openDemocracy were joined by human rights activist Peter
Tatchell, politicians from three political parties and numerous others to add their voices to the
growing chorus of objection.
In an open letter
they are demanding that the disconnections/throttling (aka technical measures) and site-blocking
clauses are either properly debated or taken out of the Bill and “subjected to genuine
democratic scrutiny in a new parliament.”
They emphasize that not only does the Bill threaten to breach human rights, suppress free speech
and hamper legitimate activities on the web, but also poses a threat to the economy.
“Democracy and accountability will be sidestepped if this bill is rushed through and
amended without debate during the so-called ‘wash-up’ process,” notes the
letter, adding: “The thousands of people we know to be contacting their MPs with concerns
will find their faith in politicians even further undermined.”
Indeed, the way this Bill has been handled from start to finish has proven deeply worrying but
even if the Government ignores all dissent and presses ahead with its implementation, along with
the suspensions, disconnections, site-blocking and all, one thing remains absolutely certain.
The main aim of propping up the “creative industries” (read: the BPI and its members)
with this legislation will fail. People will not be heading back to music stores in their
millions, they will feel bullied, intimidated and absolutely dedicated to finding new ways to
carry on regardless, just as they are in France.
And there will be half a dozen
ways to do just that and rest assured there will soon be plenty more – because people
will create them. Welcome to the arms race.
Article from: TorrentFreak, check out our new blog at
FreakBits.

|
Guardian Unlimited -
1 days and 1 hours ago
Hit F5 for updates or turn on the automatic widget below. Email Tom Bryant at tommyturbo100@hotmail.com with your thoughts on the games,
the week's football, or even if you just want some career advice. He's good like that
2.54pm: Wales are lining up 10 metres from the Italian line but are finding a
wall of blue. Eventually, Italy turn the ball over and belt it into touch. Solid defensive stuff
from the Italians.
2.52pm: Shane Williams drops the ball but is fortunate that it bounces into
Welsh hands. He is less fortunate when, standing there taking a breather, he gets chopped in half
by Bergamasco who believed he was still in possession. "Ooof," is more or less what his face
looked like.
2.50pm: Wales concede a penalty a long way out but Bergamasco lines up the kick
anyway. It's a decent effort, but it bounces off the upright. A minute later, there's some
handbags after a perceived high tackle which the referee breaks up with the exceptional line:
"You're seven foot seven and he's five foot four, don't duck into the tackle."
2.47pm: Wales' Tom Prydie, now the Six Nations' youngest ever player, is doing
alright, by the way. Just thought you'd like to know.
2.46pm: The ref has a brief conflab with his assistant and ends up awarding
Italy a penalty deep inside their own half. There's something admirable about the referees being
miked up in the rugby. Somehow it increases their authority as you hear them working through the
possibilities with their assistants. Certainly beats football where refs seem to now speak with
their hands over their mouths in case someone lip reads them going, 'WaWas that an elbow to the
face? Nah, mate, I didn't see it either'. Perhaps it's something that should be introduced to
football - at least it would make some of the more baffling decisions a bit more understandable.
2.43pm: Lewes are not at The Dripping Pan today. Pity.
Bishop's Stortford v Lewes
Bishop's Stortford: Nick Morgan, Nunn, Matt Jones, Abdullahi, Duncan, Angus,
Shulton, Prestedge, Jackman, Erskine, Docker.
Subs: Sackey, Boyle-Renner, Ritchie Jones, Pavett, Muin.
Lewes: Banks, Barness, Sutton, Pearson, Walder, Breach, Wheeler, Fraser, Rivers,
Louis, Brinkhurst.
Subs: Manning, Hopkinson, Crellin, Sigere, Keehan.
Referee: A Serrano (England)
2.42pm: Wales are getting back into it and they emphasise the fact when Stephen
Jones converts a penalty to make the score Wales 3-0 Italy.
2.41pm: Some other quite exciting stadium names, by the way: Bumthang Stadium,
Bhutan; Middlefart Stadium, Denmark; Bargain Booze Stadium (now Wincham Park),
England;sportsdirect.com@St James' Park, England.
2.38pm: Gower attempts a drop goal against the Welsh but it slides just wide.
They've already had to make a substitution but, in the initial stages, appear to be on top
against the Welsh.
2.32pm: As they kick off in Cardiff, here are some more teams for this
afternoon's Premier League fixtures:
Everton v Bolton
Everton: Howard, Neville, Jagielka, Distin, Baines, Anichebe, Heitinga, Arteta,
Pienaar, Cahill, Yakubu.
Subs: Nash, Hibbert, Yobo, Bilyaletdinov, Saha, Osman, Rodwell.
Bolton: Jaaskelainen, Steinsson, Andrew O'Brien, Knight, Robinson, Lee, Muamba,
Cohen, Wilshere, Kevin Davies, Elmander.
Subs: Al Habsi, Cahill, Taylor, Riga, Mark Davies, Ricketts, Weiss.
Referee: Alan Wiley (Staffordshire)
Portsmouth v Hull
Portsmouth: James, Mullins, Rocha, Hreidarsson, Belhadj, Smith, Mokoena, Wilson,
O'Hara, Owusu-Abeyie, Piquionne.
Subs: Ashdown, Diop, Brown, Finnan, Webber, Kanu, Basinas.
Hull: Myhill, Mendy, McShane, Mouyokolo, Dawson, Folan, Marney, Bullard,
Kilbane, Fagan, Vennegoor of Hesselink.
Subs: Duke, Barmby, Geovanni, Garcia, Cooper, Olofinjana, Cairney.
Referee: Phil Dowd (Staffordshire)
Stoke v Tottenham
Stoke: Sorensen, Huth, Abdoulaye Faye, Higginbotham, Collins, Delap, Whelan, Whitehead,
Etherington, Fuller, Kitson.
Subs: Begovic, Lawrence, Sidibe, Pugh, Sanli, Wilkinson, Moult.
Tottenham: Gomes, Corluka, Dawson, Bassong, Assou-Ekotto, Kranjcar, Kaboul, Modric, Bale, Crouch,
Pavlyuchenko.
Subs: Alnwick, Palacios, Gudjohnsen, Livermore, Dervite, Parrett, Townsend.
Referee: Mike Dean (Wirral)
Sunderland v Birmingham
Sunderland: Gordon, Hutton, Turner, Mensah, Ferdinand, Campbell, Meyler,
Richardson, Malbranque, Bent, Mwaruwari.
Subs: Carson, Bardsley, Zenden, Henderson, Da Silva, Kilgallon, Cattermole.
Birmingham: Hart, Carr, Dann, Johnson, Ridgewell, Gardner, Michel, Ferguson,
Fahey, Jerome, Benitez.
Subs: Taylor, Bowyer, Larsson, Phillips, McFadden, Parnaby, Vignal.
Referee: Peter Walton (Northamptonshire)
Wigan v Burnley
Wigan: Kirkland, Melchiot, Caldwell, Bramble, Figueroa, McCarthy, Scharner,
Diame, Thomas, Moreno, Rodallega.
Subs: Stojkovic, Gohouri, Amaya, Scotland, Moses, Gomez, Sinclair.
Burnley: Jensen, Mears, Duff, Cort, Jordan, Alexander, Elliott, McDonald,
Paterson, Steven Fletcher, Nugent.
Subs: Weaver, Edgar, Blake, Bikey, Thompson, Eagles, Cork.
Referee: Michael Jones (Cheshire)
2.31pm: Wales v Italy teams
Wales: Byrne, Prydie, Hook, J. Roberts, S. Williams, S. Jones, M. Phillips,
Jenkins, M. Rees, A. Jones, B. Davies, Charteris, Thomas, Warburton, R. Jones.
Replacements: Bennett, P. James, Gough, Delve, Peel, Bishop, Shanklin.
Italy: McLean, Robertson, Canale, Garcia, M. Bergamasco, Gower, Canavosio,
Perugini, Ghiraldini, Castrogiovanni, Geldenhuys, Bortolami, Sole, M. Bergamasco, Zanni.
Replacements: Ongaro, Aguero, Bernabo, Vosawai, Tebaldi, Bocchino,
Pratichetti.
Referee: W Barnes (RFU)
2.29pm: And here's the Welsh one. Not quite so exciting, it's fair to say. More
noble. Yes, perhaps that's the best way to describe it. It's certainly getting the full welly
from the crowd, though. Except from the coach Warren Gatland. He looks quite bored.
2.28pm: The Italians have their hands on their hearts and their other arms
around each other's backs. Great anthem, the Italian one, somehow manages to be rousing, pompous,
ridiculous, stirring and entirely characteristic of their country all at once.
2.25pm: The Italian side have run out on to the pitch at the Millennium Stadium
and seem somewhat alarmed to discover the Welsh side are nowhere in sight. Instead, there are
gian flame throwers belching fire from, apparently, the middle of the earth all round the pitch.
Understandably they form a huddle and try to igrnore it all. Eventually Wales come trotting down
the tunnel and it's anthem time.
2.23pm: As is now customary on a Saturday (i.e. when the important people are
off the weekend and the website is left to casuals/chancers) virulent betting has broken out
across the desk. The now enshrined in tradition weekly predictions game has broken out and, this
week, it looks like this:
Gregg Roughley
Everton 2-0 Bolton
Portsmouth 2-1 Hull
Stoke 2-1 Tottenham
Sunderland 1-1 Birmingham
Wigan 2-0 Burnley
QPR 2-2 Swansea
Celtic 3-0 St Johnstone
Berwick 2-0 Elgin
Evan Fanning
Everton 2-1 Bolton
Portsmouth 2-0 Hull
Stoke 1-1 Tottenham
Sunderland 1-0 Birmingham
Wigan 2-1 Burnley
QPR 2-1 Swansea
Celtic 3-1 St Johnstone
Berwick 4-4 Elgin
Josh Widdicombe
Everton 2-0 Bolton
Portsmouth 1-1 Hull
Stoke 1-2 Tottenham
Sunderland 1-0 Birmingham
Wigan 2-0 Burnley
QPR 1-0 Swansea
Celtic 3-1 St Johnstone
Berwick 3-0 Elgin
Tom Bryant
Everton 2-0 Bolton
Portsmouth 1-2 Hull
Stoke 1-2 Tottenham
Sunderland 1-1 Birmingham
Wigan 1-0 Burnley
QPR 1-2 Swansea
Celtic 3-0 St Johnstone
Berwick 0-2 Elgin
Total stakes: £12. Retirement is imminent for someone.
Good afternoon: Welcome to this Saturday's clockwatch, taking in all the games
below, the rugby and whatever else happens to float across the wires at the precise moment
they're looked at. All of it will written in
this style, but with this
soundtrack.
Incidentally, last week I went to the home of Lewes FC and
I'm struggling to think of a better-named club ground in the world. The Rooks, should you not
know, play their football at The Dripping Pan. Does it get any
better than that?
It's packed day of action at both ends of the Premier League table (if you count fourth place as
being the top of the table). Tom will be here from 2.15pm with updates from all today's football
as well as the Six Nations game between Wales and Italy at the Millennium Stadium.
There are five 3pm games in the Premier League:
Everton v
Bolton Wanderers
Portsmouth v
Hull City
Stoke
City v Tottenham Hotspur
Sunderland
v Birmingham City
Wigan
Athletic v Burnley
While you're waiting for Tom, read how Sir Alex Ferguson has branded the FA "dysfunctional" over
their failure to punish Steven Gerrard for his apparent elbow on Portsmouth's Michael Brown last
Monday. But then, you wouldn't exactly expect him to say the FA is functional, would you?
Sir Alex Ferguson has described the Football Association's disciplinary department as a
"dysfunctional unit" and called for a complete overhaul of its procedures after claiming that
Liverpool were given preferential treatment to Manchester United.
Ferguson was responding to the FA's decision not to punish Liverpool's captain, Steven Gerrard,
for the use of his forearm on Portsmouth's Michael Brown at Anfield on Monday. "I don't think
they know what they are doing," the United manager said. "But I certainly think if it was a
Manchester United player he would have been done, as was the case with Rio Ferdinand. It is crazy
at times. You scratch your head. Everybody scratches their heads at some of these decisions. You
scratch your head but it will always be that way."
Ferguson was referring to Ferdinand's three-match ban for swinging his arm into the face of Hull
City's Craig Fagan in January, a punishment that was increased to four matches when the champions
lodged an appeal.
Gerrard would have been banned from Liverpool's trip to Old Trafford tomorrow if he had been
found guilty of an FA charge of violent conduct and Ferguson alleged that the Anfield club
historically got away with more than United. "We know that. They do all right. They are lucky
like that. Maybe one day we will get lucky."
Ferguson was in one of his more outspoken moods and, as well as several thinly disguised
put-downs about Liverpool's league results, including the observation that they had overachieved
last season, he was irritated to learn that the fit-again Owen Hargreaves had been talking of
playing for England in the World Cup.
Hargreaves has been out for 19 months with knee problems after making 25 starts since signing
from Bayern Munich for £18m and Ferguson said: "I think we deserve some service first,
right? He needs to get his service in. Christ, talking about World Cups? There is nothing wrong
with talking about it. But he should be concentrating on United, right? And he will do that."
His main ire, however, was reserved for the FA. "I didn't expect anything to happen to Steven
Gerrard," he said. "It [the FA's disciplinary department] is a dysfunctional unit. There is no
consistency for a start and I didn't expect any. But there should be set rules and for years the
LMA [League Managers Association] have been trying to get involved.
"There are about 20 redundant managers around who have had good experience of the game, have good
knowledge and played the game. They could get involved and it would save [the FA] a fortune
because God knows what it costs them down there in London.
"It costs them a fortune and what results are we getting? You could ask every manager in the
league, every week, and they will tell you about inconsistency. So therefore I wonder if it's
worth the managers who don't have a job taking over that department. We could have a body of four
sitting every Sunday assessing the TV issues of the weekend. These guys have played the game and
that's the big advantage they would have over the people doing it at the moment."
Ferguson also questioned the conduct of Liverpool's players when asked about Nemanja Vidic's
record of three red cards in three games against Liverpool. "The two at Anfield were definitely
influenced by the crowd and the Liverpool players. I have looked at them again. The last one was
two yellow cards and I don't think they were right."
Liverpool, fifth in the league, are 15 points behind United at the top, and Ferguson said he had
no sympathy for Liverpool's manager, Rafael Benítez. "I don't know what they are mired
in," he said. "Their challenge last year was obviously championship form but sometimes you peak
with a particular team and it's difficult to do again. Everyone expected Liverpool to be better,
but they are not. The challenge for them now, along with a few others, is to get that fourth
spot, which is a league of its own."
Asked if he was saying Liverpool had overachieved last season, Ferguson said: "Yes. They did very
well. When they got that run going they showed form and consistency. I thought it was an
exceptional season for them but that it would be difficult to achieve that again."
He described Liverpool's 4-1 win at Old Trafford a year ago this week as "an abnormal blip" but
insisted he was not motivated by the prospect of overtaking them on 19 league titles. "I don't
think of it that way," he said. "If we win the 19th title the most important thing will be the
next one, the 20th."
Tom Bryantguardian.co.uk © Guardian News & Media Limited 2010 | Use
of this content is subject to our Terms & Conditions | More Feeds

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Slashdot -
1 days and 3 hours ago
ram.loss writes "The company I work for has decided to go paperless for all memos and internal
correspondence. In addition to the central administration, the company has three more or less
autonomous, physically separated divisions; that means we do not have a common IT infrastructure
across all of them. Since I am the only resemblance we have to an IT department at my division, I
have been commissioned with evaluating the available technology to manage and authenticate all
correspondence, although it is not my area of expertise (I have a CompSci degree, but for many
years have specialized in transportation modeling software). My initial thought was to use a
document management system like Plone (this is the system I'm familiar with); from what I have
read, that would take care of the management part, but what about authentication? We need each
document to be signed, and a fully auditable system that keeps track of who signed what document,
who received it and when. It also must take into account the handling of external correspondence in
the future, where a recipient outside the company must have the means to return an authenticated
document as a response. I'm aware that I'm leaving out a lot of details, like how the documents
will be signed, the legal implications, etc., but for the time being I'm only interested in the
experiences of the Slashdot crowd with such systems, and hopefully finding out enough information
to hand over the matter to (or hiring) somebody more qualified, once I know what to look for. Has
anybody out there used a similar system? Am I in way over my head?"
Read more of this story at Slashdot.


|
Slashdot -
1 days and 3 hours ago
ram.loss writes "The company I work for has decided to go paperless for all memos and internal
correspondence. In addition to the central administration, the company has three more or less
autonomous, physically separated divisions; that means we do not have a common IT infrastructure
across all of them. Since I am the only resemblance we have to an IT department at my division, I
have been commissioned with evaluating the available technology to manage and authenticate all
correspondence, although it is not my area of expertise (I have a CompSci degree, but for many
years have specialized in transportation modeling software). My initial thought was to use a
document management system like Plone (this is the system I'm familiar with); from what I have
read, that would take care of the management part, but what about authentication? We need each
document to be signed, and a fully auditable system that keeps track of who signed what document,
who received it and when. It also must take into account the handling of external correspondence in
the future, where a recipient outside the company must have the means to return an authenticated
document as a response. I'm aware that I'm leaving out a lot of details, like how the documents
will be signed, the legal implications, etc., but for the time being I'm only interested in the
experiences of the Slashdot crowd with such systems, and hopefully finding out enough information
to hand over the matter to (or hiring) somebody more qualified, once I know what to look for. Has
anybody out there used a similar system? Am I in way over my head?"
Read more of this story at Slashdot.

|
Journal of Neuroscience -
1 days and 9 hours ago
Publication Date: 2010 Mar 17 PMID: 20237287Authors: Kochlamazashvili, G. - Senkov, O. - Grebenyuk,
S. - Robinson, C. - Xiao, M. F. - Stummeyer, K. - Gerardy-Schahn, R. - Engel, A. K. - Feig, L. -
Semyanov, A. - Suppiramaniam, V. - Schachner, M. - Dityatev, A.Journal: J NeurosciThe neural cell
adhesion molecule (NCAM) is the predominant carrier of alpha2,8 polysialic acid (PSA) in the
mammalian brain. Abnormalities in PSA and NCAM expression are associated with schizophrenia in
humans and cause deficits in hippocampal synaptic plasticity and contextual fear conditioning in
mice. Here, we show that PSA inhibits opening of recombinant NMDA receptors composed of GluN1/2B
(NR1/NR2B) or GluN1/2A/2B (NR1/NR2A/NR2B) but not of GluN1/2A (NR1/NR2A) subunits. Deficits in
NCAM/PSA increase GluN2B-mediated transmission and Ca(2+) transients in the CA1 region of the
hippocampus. In line with elevation of GluN2B-mediated transmission, defects in long-term
potentiation in the CA1 region and contextual fear memory in NCAM/PSA-deficient mice are abrogated
by application of a GluN2B-selective antagonist. Furthermore, treatment with the glutamate
scavenger glutamic-pyruvic transaminase, ablation of Ras-GRF1 (a mediator of GluN2B signaling to
p38 MAPK), or direct inhibition of hyperactive p38 MAPK can restore impaired synaptic plasticity in
brain slices lacking PSA/NCAM. Thus, PSA carried by NCAM regulates plasticity and learning by
inhibition of the GluN2B-Ras-GRF1-p38 MAPK signaling pathway. These findings implicate
carbohydrates carried by adhesion molecules in modulating NMDA receptor signaling in the brain and
demonstrate reversibility of cognitive deficits associated with ablation of a schizophrenia-related
adhesion molecule.post to:
CiteULike

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BMC Neuroscience -
1 days and 10 hours ago
Publication Date: 2010 Mar 17 PMID: 20236508Authors: Strom, J. O. - Theodorsson, E. - Holm, L. -
Theodorsson, A.Journal: BMC NeurosciABSTRACT: BACKGROUND: : Numerous stroke studies have
controversially shown estrogens to be either neuroprotective or neurodamaging. The discordant
results observed in rat brain ischemia models may be a consequence of discrepancies in estrogen
administration modes resulting in plasma concentration profiles far from those intended. To test
this hypothesis we reproduced in detail and extended an earlier study from our lab using a
different mode of 17beta-estradiol administration; home-made silastic capsules instead of
commercial slow-release 17beta-estradiol pellets. Four groups of female rats (n=12) were
ovariectomized and administered 17beta-estradiol or placebo via silastic capsules. All animals
underwent MCAo fourteen days after ovariectomy and were sacrificed three days later. RESULTS: : In
contrast to our earlier results using the commercial pellets, the group receiving 17beta-estradiol
during the entire experiment had significantly smaller lesions than the group receiving placebo
(mean+/-SEM: 3.85+/-0.70% versus 7.15+/-0.27% of total slice area, respectively; p=0.015). No
significant neuroprotection was found when the 17beta-estradiol was administered only during the
two weeks before or the three days immediately after MCAo. CONCLUSIONS: : The results indicate that
different estrogen treatment regimens result in diametrically different effects on cerebral
ischemia. Thus the effects of estrogens on ischemic damage seem to be concentration-related, with a
biphasic, or even more complex, dose-response relation. These findings have implications for the
design of animal experiments and also have a bearing on the estrogen doses used for peri-menopausal
hormone replacement therapy.post to:
CiteULike

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Brain - current issue -
1 days and 10 hours ago
Neuro-axonal degeneration occurs progressively from the onset of multiple sclerosis and is
thought to be a significant cause of increasing clinical disability. Several histopathological
studies of multiple sclerosis and experimental autoimmune encephalomyelitis have shown that the
accumulation of sodium in axons can promote reverse action of the sodium/calcium exchanger that,
in turn, leads to a lethal overload in intra-axonal calcium. We hypothesized that sodium magnetic
resonance imaging would provide an indicator of cellular and metabolic integrity and ion
homeostasis in patients with multiple sclerosis. Using a three-dimensional radial gradient-echo
sequence with short echo time, we performed sodium magnetic resonance imaging at 3 T in 17
patients with relapsing–remitting multiple sclerosis and in 13 normal subjects. The
absolute total tissue sodium concentration was measured in lesions and in several areas of
normal-appearing white and grey matter in patients, and corresponding areas of white and grey
matter in controls. A mixed model analysis of covariance was performed to compare regional tissue
sodium concentration levels in patients and controls. Spearman correlations were used to
determine the association of regional tissue sodium concentration levels in T2- and T1-weighted
lesions with measures of normalized whole brain and grey and white matter volumes, and with
expanded disability status scale scores. In patients, tissue sodium concentration levels were
found to be elevated in acute and chronic lesions compared to areas of normal-appearing white
matter (P < 0.0001). The tissue sodium concentration levels in areas of
normal-appearing white matter were significantly higher than those in corresponding white matter
regions in healthy controls (P < 0.0001). The tissue sodium concentration value
averaged over lesions and over regions of normal-appearing white and grey matter was positively
associated with T2-weighted (P ≤ 0.001 for all) and T1-weighted (P ≤
0.006 for all) lesion volumes. In patients, only the tissue sodium concentration value averaged
over regions of normal-appearing grey matter was negatively associated with the normalized grey
matter volume (P = 0.0009). Finally, the expanded disability status scale score showed a
mild, positive association with the mean tissue sodium concentration value in chronic lesions
(P = 0.002), in regions of normal-appearing white matter (P = 0.004) and
normal-appearing grey matter (P = 0.002). This study shows the feasibility of using
in vivo sodium magnetic resonance imaging at 3 T in patients with multiple sclerosis.
Our findings suggest that the abnormal values of the tissue sodium concentration in patients with
relapsing–remitting multiple sclerosis might reflect changes in cellular composition of the
lesions and/or changes in cellular and metabolic integrity. Sodium magnetic resonance imaging has
the potential to provide insight into the pathophysiological mechanisms of tissue injury when
correlation with histopathology becomes available.

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Nature -
1 days and 12 hours ago
Publication Date: 2010 Mar 18 PMID: 20237567Authors: Huang, F. - Chakraborty, P. - Lundstrom, C. C.
- Holmden, C. - Glessner, J. J. - Kieffer, S. W. - Lesher, C. E.Journal: NatureThe phenomenon of
thermal diffusion (mass diffusion driven by a temperature gradient, known as the Ludwig-Soret
effect) has been investigated for over 150 years, but an understanding of its underlying physical
basis remains elusive. A significant hurdle in studying thermal diffusion has been the difficulty
of characterizing it. Extensive experiments over the past century have established that the Soret
coefficient, S(T) (a single parameter that describes the steady-state result of thermal diffusion),
is highly sensitive to many factors. This sensitivity makes it very difficult to obtain a robust
characterization of thermal diffusion, even for a single material. Here we show that for thermal
diffusion experiments that span a wide range in composition and temperature, the difference in S(T)
between isotopes of diffusing elements that are network modifiers (iron, calcium and magnesium) is
independent of the composition and temperature. On the basis of this finding, we propose an
additive decomposition for the functional form of S(T) and argue that a theoretical approach based
on local thermodynamic equilibrium holds promise for describing thermal diffusion in silicate melts
and other complex solutions. Our results lead to a simple and robust framework for characterizing
isotope fractionation by thermal diffusion in natural and synthetic systems.post to:
CiteULike

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Journal of Neuroscience -
1 days and 12 hours ago
Publication Date: 2010 Mar 17 PMID: 20237284Authors: van Gaal, S. - Ridderinkhof, K. R. - Scholte,
H. S. - Lamme, V. A.Journal: J NeurosciCognitive control processes involving prefrontal cortex
allow humans to overrule and inhibit habitual responses to optimize performance in new and
challenging situations, and traditional views hold that cognitive control is tightly linked with
consciousness. We used functional magnetic resonance imaging to investigate to what extent
unconscious "no-go" stimuli are capable of reaching cortical areas involved in inhibitory control,
particularly the inferior frontal cortex (IFC) and the pre-supplementary motor area (pre-SMA).
Participants performed a go/no-go task that included conscious (weakly masked) no-go trials,
unconscious (strongly masked) no-go trials, as well as go trials. Replicating typical neuroimaging
findings, response inhibition on conscious no-go stimuli was associated with a (mostly
right-lateralized) frontoparietal "inhibition network." Here, we demonstrate, however, that an
unconscious no-go stimulus also can activate prefrontal control networks, most prominently the IFC
and the pre-SMA. Moreover, if it does so, it brings about a substantial slowdown in the speed of
responding, as if participants attempted to inhibit their response but just failed to withhold it
completely. Interestingly, overall activation in this "unconscious inhibition network" correlated
positively with the amount of slowdown triggered by unconscious no-go stimuli. In addition, neural
differences between conscious and unconscious control are revealed. These results expand our
understanding of the limits and depths of unconscious information processing in the human brain and
demonstrate that prefrontal cognitive control functions are not exclusively influenced by conscious
information.post to:
CiteULike

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CrunchGear -
1 days and 16 hours ago

If you’re a photographer and use a Mac, chances are you’re using Lightroom or
Aperture. Probably Lightroom, since Aperture is less popular among pros — and the latest
version seems to be an acknowledgment of that. The features added in version 3 are clearly
intended to draw casual shooters using iPhoto to the paid image editing honey pot. Since so many
of these amazing new features are direct side-loads from iPhoto, it smooths the process and makes
the program as a whole more approachable, though whether existing Aperture users will find them
helpful is questionable. Brushes, on the other hand, are a welcome addition to any
photographer’s toolset, and depending on how dedicated you are, may be worth the price of
admission.
Invasion of the iPhoto features
As long as I’ve been using Aperture, I’ve considered it a processing
application. Its photo management was troublesome here and there, and iPhoto had the best ways of
showing off your shots, but I dealt with it since maintaining two separate libraries of the same
photos would be disk space suicide. I’ve only used Lightroom a little bit (and a version or
two back) but all my friends say that it just has a better workflow for serious photo work
— importing a couple hundred shots, scrubbing through them, doing the necessary
adjustments, and outputting to the necessary format. Not that I have trouble doing that in
Aperture, but apparently it’s faster and better in Lightroom.
Confronted with such a fearsome opponent, Apple decided that it would be better to flank than to
risk a frontal assault. Hence the expansion of Aperture’s incorporation of iPhoto features
Faces and Places. I question their relevance in a photo processing application, but given
Apple’s tendency towards coalescing functionality, I’m guessing that iPhoto will
eventually be Aperture: Gimped Edition, and the only real choice for organizing and messing with
large numbers of photos will be Aperture.
There are some kinks to be worked out. Faces plainly doesn’t work. After it spent literally
five hours going through my photos (about 1000 per hour), this is what it has come up with:
No, it didn’t have a lot to go on (I hadn’t “trained” it much yet) but
really now. After giving it a few more pointers on what I looked like, it still mistook
a three-year-old tow-headed girl, my friend Monica (who is Indian, and in a wedding dress), some
E3 booth babes, and Casio president Kazuo Kashio for pale, bearded, Devin Coldewey. The
cork board background is jarring and the interface for going through your shots is terrible. I
realize this is a technology still being perfected, and that is why I am wondering: what is it
doing in my RAW editing program?
Places is useful if you have a geotagging
camera (still rare) or want to spend a few hours dragging and dropping stuff onto the map. It can
be fun, actually, if you take a lot of pictures of your friends, and want to drag and drop this
or that night onto the location you went to; it’s like creating a different kind of album
(“Linda’s Tavern”), and indeed you can make a browsable smart album from
locations. If you’re like me, you won’t feel complete until the photos are more or
less where they were within the city, and not all grouped in a single pin, smack in the middle of
the city. This could have some promise, but with a backlog of several thousand shots, getting a
library up to date in Places is a task I wouldn’t wish on my worst enemy.
It’s a mistake to judge Faces and Places by simply saying “well we were fine before
them,” because it may just be that we found ways of working in the old system of
organization (Project>Folder>Album) that approximated what these new features do. But I
don’t think it’s wrong to say they just don’t really do much, and feel out of
place to boot. You have to work at them, or shoot for them, in order for them to really be
worthwhile. Still I have to give credit where credit’s due: if you just consider Faces and
Places new columns to organize by (like rating or date) then they’re worth their salt. As
flagship features, though, they’re duds.
Lastly, the slide show thing. It’s like finding a trout in the milk. Not that it
doesn’t work — it works as well as iPhoto’s thing, and I suppose
it’s better to have than not. It’s just a little weird to have a sort of…
aftermarket feature popped in there next to the serious editing tools. Its little presets are,
like in most Apple programs, 25% solid, 75% fluff. Who in the name of all that is holy is going
to pick “Shatter” as their slide show transition? It’s ghastly.
The new features are very well explained in little videos accessible through the
“Welcome” screen, which will be handy for new users — if they can find the
screen after they close it (it’s in Help>Welcome to Aperture).
The good stuff
So if the iPhoto features are icing, the actual cake is the RAW editing, adjustment tools, and
user interface. Let’s start with what I would say is the best new feature: Brushes.
You can see a pretty thorough overview of the feature at Apple’s site, but the gist is that
it allows you to apply certain effects in limited areas using a brush of adjustable size and
intensity. That’s great! I can’t count the number of times I’ve vacillated
between two versions of a photo where an adjustment necessary for one part ended up blowing out
another, or I just wanted to bring out the color in the eyes but not in the background. A lot of
fiddling could usually approximate the effect I wanted, but it would be so much easier to just
use a brush. I’ll be using the hell out of this feature, and it’s perhaps the only
real step Apple took against Adobe in this update.

(combination Brushes and Help Video screenshot)
The brushes are non-destructive, like any of the dials and curves you can play with in the
adjustments panel, so you can feel free to experiment, layer, and try out different effects. One
thing I often have to do when shooting review shots is emphasize the color of LEDs, but if the
subject is well-lit, the LEDs are going to be barely visible. No problem; make a little brush,
add in a little contrast right there, bump the saturation just in the one area, and boom, it
sticks out like a sore thumb. Brushes are useful for lots of little things like that.
The new full-screen browser is handy but not really a revolution. They’ve added the ability
to get around your library a little more, which is nice, but it’s not as streamlined as the
regular browser, which is always accessible by a single keystroke. The fullscreen presentation
has definitely been improved, however, and when showing off photos to friends or clients,
it’s a better option than either the plain editing window or a slide show.
The preset adjustments, I think we can agree, are being blown way out of proportion. These are
the same kind of “professional adjustments” that you have been able to apply on cheap
point-and-shoots since the beginning of time. There are a few quick adjust things like
high-contrast black-and-white or exposure +1 that are nice to have previews for (the live preview
window is handy), but let’s be honest, these are just filters. I’d like to be able to
say that they’re carefully adjusted so you won’t see weird color effects, blackouts,
or blowouts, but the fact is every one I tried looked cheap and overdone. The others, like white
balance and so on, seem pretty redundant considering the actual controls for adjusting those
aspects are mere pixels away in the same window.
Click to see it larger. You can’t really tell here, since this photo isn’t very high
contrast, but in several of the other shots I tried this on, the vintage look was really
purple, cross-processing was really green, and toy camera pushed the contrast
way too far. Subtle adjustments these are not.
The good news is that people new to the program might try a couple, see that they were created by
dragging curves and color bars around, and then make their own. I’ve had my own
“base” adjustment for years now, which was just as easily accessible and just as
customizable. Putting together a “look” for a shoot using this feature might be
easier now than before, but it’s still just a toy at this point.
The ability to have multiple libraries is nice; splitting work and personal stuff would be my
move, so that if a meteor crashed into TC HQ (or, more likely, I’m fired for
insubordination), I could free up a couple gigs in one clean sweep. It’s also convenient
for backing up and sharing; “here’s my whole ‘wedding’ library, feel free
to do what you like with it” rather than “here’s a folder full of RAW
files.”
A quick note
Just a PSA: installation of Aperture 3 took ages. Plan on losing at least a working day to 100%
processor usage as it converts your library, searches for Faces, and reprocesses your RAW files
with the new profile. I’m not holding this against Apple (it’s a LOT of data to sift
through) but it’s just something to be aware of.
Conclusion
Aperture is still a great program, in my opinion, and the budding photographer would be a lot
better off with this than with iPhoto if they’re planning on doing anything more than
collecting snapshots. I’ve gotten used to Aperture’s workflow and they haven’t
changed it much in 3, in fact they’ve provided a couple serious improvements with Brushes
and potentially Places and Faces — you know, if you’re into that kind of
thing.
The trouble I see is that Aperture, once a rather single-minded program, is being diluted with
features that have nothing to do with its core functionality. Why not have a new program, called
“Collection” or something, that hooks into all your libraries, allows for creating
robust slide shows, exporting directly to Facebook, and all that sort of thing? Putting all this
junk into Aperture is doing to it what Apple has done to iTunes: once a sleek and straightforward
program, it has now grown bloated beyond comprehension; it’s a bit like seeing a once-great
fighter gone to seed. I have more of an attachment to Aperture than to iTunes, but if Aperture 4
continues along the vector indicated by Aperture 3, you can consider me a Lightroom conversion.
Give Aperture 3 a 30-day trial for free here. $199
to buy, $99 to upgrade.


|
Guardian Unlimited -
1 days and 16 hours ago
The Iranian indie band talk about life as outlaws in their homeland, as documented in their new
film No One Knows About Persian Cats
At first glance, Take It Easy Hospital look like any other aspiring indie duo. Dressed
in impeccable Shoreditch chic – plaid shirt and skinny jeans for him, cute
vintage dress, black tights and brogues for her – their teenage epiphanies
came on copied cassettes of Nirvana and Pink Floyd, while these days they're more into Sigur
Rós and Foals.
Their ambition for next year, once they find a drummer, is to get on to the bill at Glastonbury
or Reading. The difference is that Take It Easy Hospital originally formed in Iran, where rock
music is banned. When the local music industry is non-existent, gigs and recording studios are
regularly raided by police and even MySpace is monitored, simply finding someone who shares your
love of guitars and plaintive vocals is fraught with difficulties.
Ash Koshanejad and Negar Shaghaghi, the twin songwriters of Take It Easy Hospital, are the stars
of a new Iranian film by garlanded Kurdish director Bahman Ghobadi, called No One Knows About Persian Cats (so named because pet cats,
like rock musicians, are outlawed in Iran). The film is a fictionalised account of the duo's
attempts to recruit a rhythm section in order to play a local underground gig and ultimately
escape to the rock-friendly west. As the two indie innocents are taken under the wing of
music-loving wide-boy Nader (Hamed Behdad), the film becomes a Linklater-esque romp through
Tehran's clandestine rock underground. All the bands and musicians featured are real, but whether
hairy blues rockers, jazz singers, class-war rappers or indie kids, they exhibit a love for
making music that overrides the fear of being arrested the moment they switch on their amps. "If
you were discovered playing rock music, you'd get arrested, you'd have to pay a fine," reveals
Ash, matter-of-factly. "Sometimes you'd go to prison."
The film gleans affectionate humour from the various bands' ingenuity when it comes to hiding
their rehearsal spaces from the authorities in diligently-soundproofed underground caverns,
shacks constructed on the roofs of tower blocks or, in one case, in a working cattle barn (much
to the cows' displeasure).
By coincidence, there is a British film out this month which also documents the struggle of a
couple of indie dreamers to form a band – except 1234 is based in London, so the
only obstacles are their own musical inadequacy and weedy sexual tension between bandmates.
Persian Cats makes 1234 look rather pathetic.
In Iran musicians are forced to behave like fugitives, even though the charges invoked against
them are vague (Ahmadinejad imposed a ban on "western and decadent music" soon after becoming
president in 2005). "It's a not a written law," complains Negar. "There isn't this red line. You
never know when you're crossing it. [The authorities] don't even really know what they're
opposing. They don't see that music brings energy and good nature to society."
In 2007, Ash's former band Font staged an open-air gig in a private garden in a suburb of Tehran.
Armed police arrived en masse to shut it down, arresting everyone in the audience, and slinging
the band in prison for 21 days. "They didn't have any law that said what they should do with us,
so they called us satanists. They said we were against the moral law and disgracing the face of
society." Ash chuckles wryly at the memory. "It was an odd experience, sleeping next to a serial
killer for three weeks. But it made me believe even more in what I was doing."
Font and Take It Easy Hospital are rarities: most Iranian wannabe rockers never even get further
then their bedrooms, due to the subtle pressure exerted within families. "Under this regime, you
don't have any opportunity to make a living from being a musician, so families prevent their
children from learning music in the first place," Ash explains. "Families are a small example of
big government. They don't trust the young generation."
When Ash and Negar were kids, the only opportunity they had to hear western rock music was when
somebody from their community travelled abroad and brought back CDs. "They'd be copied on to a
tape over and over again," says Negar. "We used to write the track names in class when the
teacher wasn't looking and take it home with such excitement to listen to it." Even so, whatever
they got depended on the tastes of the traveller; often hoping for something similar to Nirvana,
they'd end up having to make do with ABBA.
The advent of the internet changed everything for Iranian teenagers, who were suddenly able to
participate in global youth culture, employing their technological nous to stay one step ahead of
government censors. The fact that the bands in No One Knows About Persian Cats wear Strokes
T-shirts and pass around copies of the NME shouldn't seem that strange. But what is the
attraction to Ash and Negar of the kind of fey indie music that even within its countries of
origin is often considered a bit insular?
"Well, we are indie!" declares Ash. "We had to do it ourselves in bedrooms because if
you step out into the streets, you cannot even tell anyone you've just written a song. We would
make our own imaginariums in our rooms."
If they'd grown up in England, Take It Easy Hospital's wan, organ-driven indie-pop, topped with
earnest observations about the "human jungle", might stand accused of being a little bit twee.
But once you learn how hard Ash and Negar have had to fight just to get their songs heard, they
take on a whole new complexion. And despite their ugly experiences in Iran, they are determined
not to make rebel rock. "Me, I don't care about politics," says Negar. "The value of art is a lot
more than politics. Politics is something that passes, but art stays for years."
Ash picks up the thread: "Politics is a tool to solve a situation at one moment. We believe that
art is pure and always depending on human nature, so we've always kept ourselves far from
politics. Our music is not dangerous, but the current regime in Iran feels that it has to keep
people away from honest expression because if they face up to the reality they will soon find out
what they are missing."
Ash and Negar agreed to star in Persian Cats not to make a political point, but to try to show
the older generation, including their parents, that music is a force for good. But while Ash has
received some positive feedback from older Iranians – "I've heard that they
walk away after seeing this film to remember what they had before the revolution"
– Negar is despondent that most of them haven't been able to overcome their
prejudices. "I guess that when people decide to close their eyes to something, you can't force
them to see the truth."
In the light of last year's post-election protests, the police crackdown on young people involved
in music and the arts has intensified. When Take It Easy Hospital's old drummer went back to Iran
several weeks after the election, he was arrested and beaten. Last January, the film's co-writer,
Iranian-American journalist Roxana Saberi, was arrested in Tehran and handed an eight-year jail
sentence on trumped up charges of being a US spy (she was eventually freed following a global
outcry).
Reluctantly, Ash and Negar decided it was unsafe to return to Iran and have successfully applied
for asylum in the UK, where they've been living since coming over to play at Manchester's In The
City festival in 2008. In the film, the duo never make it to London, so in this case, truth is
happier than fiction. However, Negar is at pains to point out that they never viewed England as
the promised land, despite our rather more relaxed laws regarding the public airing of
Farfisa-driven jangle pop.
"Some people say we've run away," says Negar. "But there is no running away. Moving from one
country to another doesn't necessarily solve all the problems that are on your mind." Proof that
indie introspection truly is an international language.
No One Knows About Persian Cats is out Fri; it previews at Brixton
Ritzy, SW2, Tue
Sam Richardsguardian.co.uk © Guardian News & Media Limited 2010 | Use
of this content is subject to our Terms & Conditions | More Feeds

|
Nature -
1 days and 17 hours ago
Publication Date: 2010 Mar 18 PMID: 20237562Authors: Lin, H. K. - Chen, Z. - Wang, G. - Nardella,
C. - Lee, S. W. - Chan, C. H. - Yang, W. L. - Wang, J. - Egia, A. - Nakayama, K. I. - Cordon-Cardo,
C. - Teruya-Feldstein, J. - Pandolfi, P. P.Journal: NatureCellular senescence has been recently
shown to have an important role in opposing tumour initiation and promotion. Senescence induced by
oncogenes or by loss of tumour suppressor genes is thought to critically depend on induction of the
p19(Arf)-p53 pathway. The Skp2 E3-ubiquitin ligase can act as a proto-oncogene and its aberrant
overexpression is frequently observed in human cancers. Here we show that although Skp2
inactivation on its own does not induce cellular senescence, aberrant proto-oncogenic signals as
well as inactivation of tumour suppressor genes do trigger a potent, tumour-suppressive senescence
response in mice and cells devoid of Skp2. Notably, Skp2 inactivation and oncogenic-stress-driven
senescence neither elicit activation of the p19(Arf)-p53 pathway nor DNA damage, but instead depend
on Atf4, p27 and p21. We further demonstrate that genetic Skp2 inactivation evokes cellular
senescence even in oncogenic conditions in which the p19(Arf)-p53 response is impaired, whereas a
Skp2-SCF complex inhibitor can trigger cellular senescence in p53/Pten-deficient cells and tumour
regression in preclinical studies. Our findings therefore provide proof-of-principle evidence that
pharmacological inhibition of Skp2 may represent a general approach for cancer prevention and
therapy.post to:
CiteULike

|
Mashable! -
1 days and 17 hours ago
Kevin Nakao is VP of Mobile & Business Search for
WhitePages, a Top 40 Web and Mobile
Publisher. You can find him on Twitter,
and on the Whitepages
Blog where he writes about mobile, local, and social media.
While last year’s SXSW seemed to serve as the
“coming out” party for location-based services (LBS), maybe this year’s
conference signifies the migration of these platforms into mainstream culture. And perhaps the
only real “new” concept to emerge this year is the idea that there is finally a real
opportunity to make money via “location.”
Here are five things that companies should consider as they look to utilize location-based
services (LBS) as part their mobile strategy.
1. Location Shouldn’t be the Only Goal
From finding the nearest ski slope on REI’s Ski and Snow Report to a nearby movie on Flixter, there are
plenty of Top iPhone applications that have incorporated a “lead with the offer, not the
capability” philosophy into their mobile product offering to provide a better service.
Build the best service first, then add the bells and whistles.
With all the hoopla surrounding location, it is easy to lose sight of the fact that
location’s real appeal to advertisers is the fact that with this functionality, you can
reach the on-the-go user, who is ready to buy and consume. Just because Twitter and Facebook offer location doesn’t make
that valuable or new to advertisers. Location-targeting via IP address has been around a while.
For the same reason radio is a great advertising channel for retailers, LBS advertising is also
valuable: because it can reach the consumer near the point of sale.
2. The “Long Tail” for User Adoption
Foursquare has clearly emerged as the location
darling. Consider the fact that after only one year, they’ve reached 500,000
active users (Foursquare recently tweeted they added 100,000 users in 10 days).
However, if you apply any city’s share of the total U.S. population, the results show some
pretty low estimates of Foursquare users in individual localities. What emerges is a very
“long tail” — a steep, narrow graph — of local user adoption. This shows
why it is important to achieve scale if you hope to see return on investment in the location
marketing space.
For example, using these rough estimates of a city’s proportional share of the U.S. population, if a
local pet supply store wanted to target people in San Francisco, the estimated reach would be
1,310 Foursquare users. Even if you double this audience estimate, the number is fairly small for
even a local marketer. We had to hit around 4 million downloads of the Whitepages iPhone app to
achieve the minimum scale needed for advertiser geo-targeting. Today, 80% of our campaigns from
major brands are geo-targeted.
Editor’s Note: It’s important to remember that these are just rough estimates.
Because Foursquare was initially only available in a handful of major metro areas, the geographic
distribution of users may not precisely follow the geographic distribution of the
population.
3. Mobile Battery Life is Key
Battery life is the single biggest threat to location. With GPS on, the phone is asking the
network where it is, and this chatter can drain battery life — anyone with an iPhone knows what I am referring to. Thus, phone
manufacturers will play a critical role in the future of LBS. RIM, the manufacturer of BlackBerry devices, faced this problem early on with
the energy-tax of e-mail polling, and as a result, their devices now have some of the best
battery life.
Foursquare has helped us move forward here as well. “Check-ins” help to address the
issue as they offer efficient geo-triggers without having to keep battery-draining GPS features
on at all times.
4. Location Will Be the Battleground of the Mobile OS
Looking forward, I predict the mobile platform wars will be fought with location and maps. This
is an important feature that a platform can use as a point of differentiation for consumers and
developers.
In anticipation of that battle, Apple purchased mapping company Placebase, and Google is starting to provide unique
mapping features like turn-by-turn navigation on
its Android devices. The only hope I see for
Windows Mobile is if they do something
completely revolutionary on the mobile location front. A development like this was alluded to at
the recent TED conference with its augmented reality
layering of geo-tagged Flickr photos and real-time
video integration.
5. Location Pays
At WhitePages, we monetize our mobile services through a mix of premium, national display, and
sponsored links for local business. Our effective CPM (revenue per thousand ad impressions) for
sponsored local links is $30-$50 — double the effective CPM (eCPM) rate we see for premium
display ad campaigns from national brands. The eCPM multiple of local targeted ads over ad
network rates is a staggering 10x.
Location-based inventory will also become scarce as Apple recently
announced that iPhone apps will not be permitted to access GPS capabilities for advertising
alone. There now needs to be some consumer benefit and functionality in order to access a
user’s location. Geo-targeted inventory on mobile will continue to be at a high premium
with no excess supply or ad networks to drive it down.
Conclusion
It is my hope that by this time next year, SXSW –- the festival of
“emerging” music and technology –- will have finally moved on from
location. It’s clearly happening now, and if integrated wisely, location will be making
companies too much money to be called the “cool kid on the block” any longer
More location-based resources from Mashable:
- 9 Killer Tips for
Location-Based Marketing
- 10 Foursquare Apps You Can Use
Right Now
- 6 Foursquare Apps We’d Love to
See
- 6 Tips for Getting the Most out of
Foursquare
- Foursquare vs. Gowalla:
Location-Based Throwdown
- Location, Location,
Location: 5 Big Predictions for 2010
Tags: android, business, foursquare, geo-tagging, gowalla, iphone, List,
Lists, location based advertising, location-based, Longtail, MARKETING, Mobile 2.0, small business


|
Nature -
1 days and 18 hours ago
Publication Date: 2010 Mar 18 PMID: 20237561Authors: Ma, L. J. - van der Does, H. C. - Borkovich,
K. A. - Coleman, J. J. - Daboussi, M. J. - Di Pietro, A. - Dufresne, M. - Freitag, M. - Grabherr,
M. - Henrissat, B. - Houterman, P. M. - Kang, S. - Shim, W. B. - Woloshuk, C. - Xie, X. - Xu, J. R.
- Antoniw, J. - Baker, S. E. - Bluhm, B. H. - Breakspear, A. - Brown, D. W. - Butchko, R. A. -
Chapman, S. - Coulson, R. - Coutinho, P. M. - Danchin, E. G. - Diener, A. - Gale, L. R. - Gardiner,
D. M. - Goff, S. - Hammond-Kosack, K. E. - Hilburn, K. - Hua-Van, A. - Jonkers, W. - Kazan, K. -
Kodira, C. D. - Koehrsen, M. - Kumar, L. - Lee, Y. H. - Li, L. - Manners, J. M. - Miranda-Saavedra,
D. - Mukherjee, M. - Park, G. - Park, J. - Park, S. Y. - Proctor, R. H. - Regev, A. - Ruiz-Roldan,
M. C. - Sain, D. - Sakthikumar, S. - Sykes, S. - Schwartz, D. C. - Turgeon, B. G. - Wapinski, I. -
Yoder, O. - Young, S. - Zeng, Q. - Zhou, S. - Galagan, J. - Cuomo, C. A. - Kistler, H. C. - Rep,
M.Journal: NatureFusarium species are among the most important phytopathogenic and toxigenic fungi.
To understand the molecular underpinnings of pathogenicity in the genus Fusarium, we compared the
genomes of three phenotypically diverse species: Fusarium graminearum, Fusarium verticillioides and
Fusarium oxysporum f. sp. lycopersici. Our analysis revealed lineage-specific (LS) genomic regions
in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the
genome. LS regions are rich in transposons and genes with distinct evolutionary profiles but
related to pathogenicity, indicative of horizontal acquisition. Experimentally, we demonstrate the
transfer of two LS chromosomes between strains of F. oxysporum, converting a non-pathogenic strain
into a pathogen. Transfer of LS chromosomes between otherwise genetically isolated strains explains
the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F.
oxysporum. These findings put the evolution of fungal pathogenicity into a new perspective.post to:
CiteULike

|
BetaNews.Com -
1 days and 18 hours ago
By Scott M. Fulton, III, Betanews
The key issue at the heart of Viacom's case against Google and YouTube, filed in March 2007,
concerns whether an Internet service that probably knows that files are traded or shown
illicitly or without license there, deserves the "safe harbor" provisions of the Digital
Millennium Copyright Act that protect ISPs from liability for their customers' actions. In a
summary judgment motion filed yesterday with US District Court in New York and unsealed this
morning, Viacom is bidding to have the judge wrap up the case -- an obvious signal that it
believes its case is already strong enough.
As US law stands now, a service such as Grokster or the original Napster (not the Best Buy
division that today uses that name) is liable when it intentionally establishes its service for
the express purpose of trading in illicit files. It's especially liable when it finds some way to
advertise itself for that purpose. An Internet Service Provider such as Comcast or Cox is not
liable when its service is used for accessing one of these sites, when it doesn't advertise or
offer these services explicitly, and when a customer can access them without direct intervention
from the ISP. And a video site such as Veoh
is not liable when any measure it might take to stop customers from sharing illicit files may
also conceivably infringe upon the free speech rights of other customers who may not be trading
such files.
Google, the current owner of YouTube, has been arguing the Veoh case in its own defense. But
Viacom's argument -- which courts have been wrestling with for over two-and-a-half years and
which we now know today -- is that YouTube is a different, special case. It's more like Grokster,
it argues, in that it was founded on the principle of gathering an audience around illicit files.
"Defendants are liable under Metro-Goldwyn-Mayer Studios Inc. v. Grokster Ltd., because
they operated YouTube with the unlawful objective of profiting from (to use their phrase)
'truckloads' of infringing videos that flooded the site," reads the opening passage of YouTube's
founders single-mindedly focused on geometrically increasing the number of YouTube users to
maximize its commercial value. They recognized they could achieve that goal only if they cast a
blind eye to and did not block the huge number of unauthorized copyrighted works posted on the
site. The founders' deliberate decision to build a business based on piracy enabled them to sell
their start-up business to Google after 16 months for $1.8 billion. The Supreme Court in Grokster
found no legal or societal justification for such intentional copyright infringement."
FOR MORE:
In a talking points document released today (PDF available
here), Viacom cites various e-mails from various YouTube and Google executives, including
YouTube founders Chad Hurley (CEO) and Steve Chen (CTO). Assuming these excerpts were not taken
out of context, which is possible, they indicate that YouTube's founders were clearly building up
a high-audience business with illicit files at their core, with the intention of selling out to
somebody as soon as possible.
One excerpt has Chen suggesting that YouTube, apparently during its startup phase,
"...concentrate all our efforts in building up our numbers as aggressively as we can through
whatever tactics, however evil." Another suggestion, by an unnamed YouTube exec in response to an
non-excerpted suggestion -- apparently asking, where should be get all this content -- reads,
"Steal it! . . . We have to keep in mind that we need to attract traffic. How much traffic will
we get from personal videos?"
And one excerpt attributed to Chen suggests that the whole legal process of handling DMCA
takedown notices is so long and dragged on, that by the time YouTube should ever comply with one,
it would be too late anyway: "But we should just keep that stuff on the site. I really don't see
what will happen. What? Someone from CNN sees it? He happens to be someone with power? He happens
to want to take it down right away. He get in touch with cnn legal. 2 weeks later, we get a cease
& desist letter. We take the video down."
Viacom's argument that Google knows what kind of trafficking goes on via YouTube is substantiated
by evidence in the form of e-mails, evidently sent prior to its acquisition of YouTube, from
executives objecting to elements of what they perceived to be its business model. One message
from Google's then-VP of Content Partnerships David Eun (now with AOL) to CEO Eric Schmidt
cautioned, "I think we should beat YouTube . . . but not at all costs. [They are] a video
Grokster." And in another excerpt, an unnamed Google executive asks, "Is changing policy [to]
profit from illegal downloads how we want to conduct business? Is this Googley?"
Evidence cited in Viacom's motion for summary judgment tells the story of how Google Video failed
to be competitive against YouTube, even though its engineers persisted with efforts to filter out
illicit content. One memo cited says Google Video may have been throwing out 90% of its uploads,
for containing suspected copyrighted material or for being generally indecent.
"But Google's good intentions and compliance with the law were not paying off," Viacom argues.
"YouTube was way ahead of Google Video in the race to build up a user base. Google executives
understood that YouTube's success was largely due to what they euphemistically labeled its
'liberal copyright policy' of freely allowing infringing material. Losing the user race to
YouTube because of the latter's copyright infringement, Google Video executives engaged in a
'heated debate' in 2006 'about whether we should relax enforcement of our copyright policies in
an effort to stimulate traffic growth.' A top senior executive, Peter Chane, Google Video's
Business Product Manager, argued point blank that Google Video should 'beat YouTube' by 'calling
quits on our copyright compliance standards.' Chane specifically advocated switching Google Video
to YouTube's 'reactive DMCA only' policy because 'YouTube gets content when it's hot
([Saturday Night Live's] Lazy Sunday, Stephen Colbert, Lakers wins at the buzzer)' and
it '[takes us too long to acquire content directly from the [legitimate] rights holder.'"
It is that statement which Viacom appears to present as a smoking gun: a suggestion from a Google
Video executive that it should acquire its competitor solely because its allegedly illegitimate
business model is more successful than its own, legally compliant one.
In Google's memorandum in support of summary judgment in its favor, filed after Viacom, its
attorneys do not take the tack or rebutting Viacom's scorching citations -- which, if
substantiated, could theoretically become the basis for future criminal complaints.
Instead, Google reiterates the argument that it's a service provider which, like Veoh, is
entitled to safe harbor since it looks the other way, and does not actively seek infringing
uploads.
Citing the Veoh finding, Google's attorneys argue, "What matters is that Veoh 'established a
system whereby software automatically processes user-submitted content and recasts it in a format
that is readily accessible to its users...Inasmuch as this is a means of facilitating user access
to material on its Web site,' Veoh did not lose the safe harbor 'through the automated creation
of these files.' YouTube is indistinguishable from Veoh in these respects."
YouTube, Google argues, did not have direct knowledge of the circumstances whereby the specific
content Viacom claimed was infringed upon (much of it from Paramount) was shared with YouTube
users. Since Viacom's arguments must, at some point, focus themselves upon the specific
infringing of the content in question, the DMCA protects YouTube on that count as well, Google
continues. But all that may be moot, Google points on, by virtue of the fact that under current
US law, the alleged infringers must have directly profited from their actions. YouTube gains
revenue through advertising.
Writes Google, "A service provider loses safe harbor eligibility only if the plaintiff can show
both that the service provider had the right and ability to control the alleged
infringements and received a financial benefit directly attributable to those
infringements...As with knowledge, the DMCA's control inquiry is specific, not general. The
analysis focuses on the service provider's legal and practical control over the particular
infringing activity at issue. The statute's text makes that clear: The question is whether
the service provider has the right and ability to control "the infringing activity"
alleged by the plaintiff and to which a financial benefit is directly attributable."
A number of declarations in support of both motions were filed today. One supporting Google was
particularly interesting, because it goes to specifically that last paragraph: It's from the
owner of a marketing firm who promoted the works of recording artists who appear on MTV, a Viacom
property. He claimed that some of the very works Viacom claimed were infringed upon through
unauthorized uploading to YouTube, actually were authorized by none other than MTV
itself, as part of the promotion of the artists under his contract.
If Google's interpretation of the law is affirmed, and if this gentleman's claims are proven,
then this whole case could become history faster than a judge can even say "summary
judgment."
Copyright Betanews, Inc. 2010


|
Mashable! -
1 days and 19 hours ago
Researching topics such as health, diet, and
(especially) the effectiveness of dietary supplements can be hard and time-consuming. Obscured by
thousands of marketing tricks, finding the truth takes days, if not weeks of research.
So, when someone puts in the time to do the research and create an infographic that makes certain
aspects of these topics easy to understand, it can be a huge time saver. Read on for some of the
best health-related infographics we’ve found online.
As always, consider the figures in these infographics with a grain of salt. No one guarantees
that the numbers are correct, and some of them are definitely open to interpretation.
1. Dietary Supplements
This is, without exaggeration, the most amazing and useful infographic I’ve ever
encountered. It looks fairly simple, but it took many hours of research to create it, and it is,
to my knowledge, the best resource about the actual efficiency of various dietary supplements out
there. From the author:
“This image is a “balloon race”. The higher a bubble, the greater the evidence
for its effectiveness. But the supplements are only effective for the conditions listed inside
the bubble.”
The graphic shows the effectiveness of health supplements on the Y-axis (higher is better), and
uses the size of the bubbles to illustrate the popularity of that particular supplement among US
adults. Anything below the “worth it line,” doesn’t have enough evidence of
medicinal benefit and is probably not worth your time, according to the graphic’s creators,
who looked at data from over 1500 studies on both PubMed (US National Library Of Medicine) and
Cochrane.org. The infographic effectively
combines data on both popularity and medical benefits to create a resource that points out the
best health supplements, as well as which ones American consumers believe in the most.
Check out the interactive version, which lets you filter the supplements by function, here.
2. Should You Drink Tap Water?
This is a look at five most and least polluted water systems in America (in larger cities),
showing that not all tap water has been created equal.
If you’ve been struggling with the issue of drinking tap or bottled water, this info might
help you make a decision. Of course, the data in this infographic, created by GOOD, covers only 10 cities, but it
highlights an important point – not all chemicals that can appear in tap water are
regulated. The graphic illustrates how many pollutants are found in each water system, how often
they’re found, and what type of bacteria exists.
See a much larger version of the image here.
3. Obesity in the USA
Obesity is a known problem in the USA, but which states are affected the most? This is the most
recent infographic on the subject we could find, listing obesity rates in all US states, as well
as obese and overweight children rates in the USA.
Besides these numbers, this attractive infographic highlights several important points; such as
overall high rates of obesity among high school students, as well as the direct and indirect
costs of obesity to the US budget.
The full version can be found
here.
4. The Cost of Health Care
Right now, one of the most debated topics in the USA is health care reform, and how much the
proposed health bill will cost individuals and business. But how much are people paying for
health care in other countries around the world?
This infographic, created in a collaboration between GOOD and Way Shape Form,
shows the average life expectancy in various countries (indicated by the fullness of the IV
bags), as well as several other health-related stats, such as infant mortality rates, and the
cost of health care.
See the zoomable version here, or a very big image here.
5. Fatality Rates for Different Diseases
This visualization was created by David
McCandless, the creator of the Snake Oil infographic mentioned above. It’s a slightly
morbid chart, showing the average fatality rates for known diseases — the size of the
bubble indicates how likely you are to die from a given disease (larger is more fatal).
It comes, however, with an optimistic second chart. The X-axis shows the fatality rate, but the
Y-axis shows how long the cause of the illness can survive outside of the body in ideal
conditions. Lesson: wash your hands!
Know of any other great health-related visualizations or infographics? Let us know in the
comments!
Tags: health, infographic, visualization


|
Ars Technica -
1 days and 19 hours ago
Rousseau, Hobbes, and Locke all meditated on the development of social contracts that they
considered necessary for people to operate in large societies. Game theory gives scientists a
chance to test some of these ideas with hard data. By having people play anonymous games with
money, researchers found that people from larger societies, ones that are more integrated into
the market, are more likely to be fair in anonymous dealings; these same people are more willing
to punish others when they are unfair. These findings suggest that fairness and punishment in
dealings with strangers are largely learned behaviors, and that we need these norms and
institutions to prevent our communities from fragmenting.
Before ten thousand years ago, localized groups probably had fairly limited contact with more
distant human populations. Fast forward a few thousand years, and large, complex, and cooperative
societies had become prevalent. Scientists have long been uncertain what facilitated the social
changes that allowed people to feel comfortable trading with others they hardly knew.
Read the comments on this post


|
Read/WriteWeb -
1 days and 19 hours ago
Once upon a time, you had to bring travel guides, maps and paper tickets
on every trip. Today, you can just take your smartphone and get access to all of this information
without having to lug a couple of books and magazines around with you. Today, according to a
new
study by analytics firm Compete, 38% of smartphone users conduct travel research on their
devices and 28% use their phones to book at least some of their trips and travel activities.
Sponsor
Compete found that the most popular travel-related activity for smartphone owners is finding more
information about a destination while they are already traveling (34%). Close to a third of
smartphone owners who responded to Compete's survey also use their phones to check up on the
status of their lodging and transportation reservations. For most smartphone owners, this
probably means checking up on the status of their flights. A quarter of smartphone owners also
use their phones to research lodging, destination and transportation options. Marketers will be
happy to hear that 22% of users look for a specific transportation company's or hotel's website
and 21% use their devices to do research on a specific travel agency's site.
Interestingly, though, while about a third of smartphone owners use their devices for
travel-related activities, only one-fifth of all smartphone owners have installed travel apps on
their devices yet. Those who haven't installed travel apps yet are looking for comprehensive
services that can notify their users of unplanned schedule changes (52%), notify users of rate
changes (48%) and consolidate all travel reservations into one itinerary. While there are already
numerous apps like WorldMate and TripIt that solve these problems, there is clearly an opportunity for
these companies to market their apps to a wider audience that isn't aware of them yet.
Discuss


|
Media Matters for America -
1 days and 19 hours ago
With a possibile vote to finalize passage of health care reform approaching, Fox News has thrown
everything but the kitchen sink to rally opposition, with guest host Laura Ingraham proclaiming,
"Let's kill the bill." For example, Fox News personalities have portrayed the nonpartisan
Congressional Budget Office as unreliable, falsely claimed that a 2006 earthquake did not occur
and attacked an 11-year-old and his family that support reform.
Fox News sets up oppo shop for the weekend
Ingraham on hosting for Fox News: "Let's kill the bill!" Fox News contributor
Laura Ingraham posted the following message on her Twitter account: "I'll be hosting the O'Reilly
Factor on Friday, 8pm eastern. Let's kill the bill!"
From Ingraham's March 19 post
on her Twitter account:
Beck encourages viewers to hold candlelight vigil against health care reform.
Glenn Beck asserted: "It is time that you
have a candlelight vigil. You peacefully assemble in front of your Congressman's local doors. You
go to his office locally, not to Washington. You gather your friends and you stand there, you
sleep there. You make sure the press covers a peaceful assembly of people saying, 'We will
remember your name 'til the end of time, sir.'" [Fox News' Glenn Beck, 3/15/10]
The Fox Nation highlights "call to arms" in opposition to health care reform. On
March 18, The Fox Nation published a
headline, "Alert: Jon Voight's Call to Arms - Come to D.C. Sat. to Oppose Obamacare."
Fox & Friends channels GOP on "facts that people need to know" about health
care reform. Fox & Friends co-host Steve Doocy announced: "So the
Republicans have put out some facts that people need to know about this." Fox News then displayed
images under the heading, "GOP: What you need to know. Facts on the Dem health bill." Doocy
continued: "For instance, they say, what they're not talking about is the fact that there's going
to be a new Medicare tax on capital gains." [Fox News' Fox & Friends, 3/19/10]
Cavuto promotes weekend coverage tilted toward conservatives. Your
World host Neal Cavuto has promoted
his upcoming "Health Care Showdown: What's really up Doc?" coverage, which will air on Saturday,
March 20. Cavuto will host conservative radio host Mark Levin, Rep. Jason Altimire (D-PA), Dom
Imus, and Mike Huckabee. Cavuto also promoted Friday's Your World guests, including Rep.
Elijah Cummings (D-MD), conservative radio host and columnist Jeri Thompson, Rep. Paul Ryan
(R-WI), and Republican candidate for California governor Carly Fiorina.
Fox hosts Gene Simmons to bash health care and promote his insurance company.
During Fox News' America Live, host Megyn Kelly hosted K.I.S.S. front man Gene Simmons to discuss
health care. During his appearance, Simmons called health care reform "horrific" and promoted his
life insurance company.
Fox News' weeklong assault: Distortions and falsehoods abound
Fox falsely attributes doctor survey to New England Journal of
Medicine. Bill O'Reilly, Glenn Beck, Brian Kilmeade, Sean Hannity and Marc Siegel
all pushed the false claim that a New England Journal of
Medicine (NEJM) survey found that 46 percent of primary care
physicians would consider leaving their profession if health care reform legislation passes. In
fact, NEJM says they didn't publish or conduct the 3-month-old email "survey," which was
actually conducted by The Medicus Firm and published in an employment newsletter.
Fox News erases 2006 Hawaii earthquake to attack Obama. Responding to President
Obama's statement during a Fox News interview that Hawaii "went through an earthquake" and could
benefit from a health care reform provision that would help Louisiana cope with Medicaid
shortfalls resulting from Hurricane Katrina, Doocy asked, "What Hawaiian earthquake?" In fact, as
Fox News itself reported at the time, President Bush declared a "major disaster" after Hawaii was
hit by a magnitude 6.7 earthquake in October 2006. [Fox News' Fox & Friends,
3/18/10]
Beck attacks family of 11-year-old who spoke about his mother's death at health
care event. Following 11-year-old Marcelas Owens' appearance at a health care
reform event to speak about his mother, who reportedly died after losing her health insurance,
Beck asked, "Where was grandma" when Marcelas' mother was sick and attacked her work with the
organization Washington Community Action Network, saying the group was "all about economic,
racial, gender, and social justice for all," which he called, "pesky phrases." [Fox News'
Glenn Beck, 3/15/10]
Fox calls CBO score untrustworthy. After the Congressional Budget Office
estimated that the health care reform reconciliation package would reduce the deficit by $130
billion over 10 years, Fox News -- led by Beck, Hannity, Doocy, Fox News anchor Bill Hemmer and
The Fox Nation -- attempted to
portray the nonpartisan CBO as untrustworthy and unreliable. By contrast, after the CBO gave
a "favorable" score to the GOP health care plan, Fox praised the office as "nonpartisan" and
advanced false GOP claims about the CBO's findings.
Fox News suggests Dems were bought off to support health care reform. Dick
Morris suggested that Obama "illegal[ly]"
nominated Rep. Jim Matheson's (D-UT) brother Scott "to a judgeship with an implicit quid pro
quo." Rep. Matheson's office and the White House have called the smear "ridiculous" and
"absurd," former Bush-appointed judge Michael McConnell definitely debunked the smear and conservatives
have stated that Scott Matheson is "plenty qualified for the job." Likewise, following Rep.
Dennis Kucinich's (D-OH) appearance on Fox & Friends to discuss his decision to
support the bill, Fox News displayed a
graphic stating: "What was Kucinich promised? Congressman changed vote from no to yes."
Fox anchors falsely attack House rule as
undemocratic. Fox News anchors, during their self-described daytime
"news hours," repeatedly forwarded
the false suggestion that by using a legislative procedure known as the "self-executing rule" to
finalize health care reform in the House, Democrats would be passing health care reform "without
actually voting for it." In fact, passing legislation by using the procedure would require a
majority vote. Fox News contributor Newt Gingrich criticized the rule as "incredible" and
"passing bills without voting on them," despite the fact that the Republican Party
"set new records" for its use of the self-executing rule in the years following Gingrich's
ascension as Speaker.
Grasping at straws: Fox News regurgitates tired health care
falsehoods
Fox repeatedly inaccurately reported on abortion
funding. Doocy, Hemmer, Kilmeade, Bill O'Reilly, Carl Cameron, Dana Perino and Greta Van Sustren pushed the
debunked claim that the Senate health
care reform bill contains language that would allow federal funding for abortion beyond what is
currently allowed under federal law. In fact, the Senate bill -- which will be considered by the
House -- prohibits health insurers from using federal subsidies to pay for abortion services
restricted by current federal law.
Hemmer perpetuates debunked health care myth: "Could
people be going to jail for not owning health insurance?" Hemmer revived the debunked myth that not buying health
insurance "could lead to prison" and asked: "Could people be going to jail for not owning health
insurance?" In fact, the penalty for
failure to purchase insurance is a tax, not jail time, and willful failure to pay taxes of any
sort can result in civil or criminal penalties.
Perino misleads on Medicare tax impact on small
businesses. Guest hosting on Fox & Friends, Perino
trumpeted the myth that a Medicare
investment tax on those making more than $200,000 would affect most small business owners. In
fact, fewer than 1.3 percent of small business owners would be affected by the tax.


|
Read/WriteWeb -
1 days and 19 hours ago
News
broke yesterday that popular online Q&A startup Formspring.me had raised some $2.5 million in venture funding and
would be relocating to Silicon Valley from Indianapolis. As a user and fan of the service, I am
happy to see the company rewarded for its success, and I am excited to see how they can improve
their already great product. However, as a follower of the national and global startup culture,
it is a little disappointing to see the company leave their home and head west to the Valley.
Sponsor
Formspring.me was spun out of Formspring.com, a platform for
creating online forms, when users began creating forms to answer personal questions. According to
the New York
Times' Brad Stone, Formspring.me has raked in $2.5 million from investors based solely in
Silicon Valley. VC firms Baseline Ventures and Freestyle Capital teamed with angels Kevin Rose, Dave Morin and Ron
Conway's SV Angel to provide Formspring.me with some well deserved, and high profile funding.
Silicon Valley is certainly the mecca of venture capital and social web applications, and in many
ways, moving the company to the Valley is a smart move. As we mentioned back in January,
Formspring.me plans
to rewrite its application to scale more efficiently as the product grows in popularity -
something that requires talented programmers. The company has already listed four job openings in San
Francisco for a pair of developers, a designer and a data analyst.
By moving to the Valley, Formspring.me will be able to tap the enormous talent pools to find top
tier programmers and designers to take their app to the next level. If they want to build out an
API and create mobile applications for their app, they are in the right place to do it. When the
time comes to look for further funding, having set up shop in the Valley will certainly benefit
the company in their efforts.
For other cities
outside of the Valley looking to build competitive startup and venture capital communities,
these are unfortunate truths. It is not uncommon to see successful startups leave their cities of
birth for the Valley to find talented employees and raise their chances for finding funding. We
recently discussed Chicago's growing
startup scene, which is not far from Indianapolis, but the opportunities in the Midwest do
not yet compare to those available in other booming startup cities.
Had Formspring.me been founded in a city like Austin,
Boulder,
New York
or Boston,
they would have likely remained there upon receiving funding. That is, perhaps, if they received
funding locally. While the Midwest is growing its startup culture, there are far fewer VC firms,
and far smaller talent pools when compared to other locations. Until more cities have their own
thriving startup scene, stories like Formspring.me's will continue to play out across the
country.
The fact that Formspring.me attracted funding from the Valley before relocating raises the
question of whether the decision to move was theirs or if it was a recommendation or stipulation
of the investors. We have reached out for comment on this question and will update this post as
more information becomes available. In the meantime, let us know what you think of Formspring.me
or any other startup moving to the Valley in the comments.
Disclosure: The New York Times is a syndication partner of ReadWriteWeb
Discuss


|
CiteULike: Borelli's watchlist -
1 days and 19 hours ago
Journal of Plant Growth Regulation, Vol. 26, No. 2. (1 June 2007), pp. 106-117.
Abstract The gaseous phytohormone ethylene is a key regulator in plant growth and
developmental process as well as biotic and abiotic stress response. This review focuses on the
recent advances in the ethylene-signaling pathway in Arabidopsis, with particular emphasis on the
latest information about the downstream events of the ethylene-response pathway. Notable new
findings include identification of a specific regulator of the ethylene receptor ETR1, discovery of
protein degradation and RNA turnover processes in modulating EIN3-dependent transcriptional
regulation, demonstration of the involvement of auxin biosynthesis in ethylene-mediated inhibition
of root growth, and determination of possible integration points between ethylene and other
hormonal and environmental signals (gibberellin, jasmonic acid, light, and sugar) in various plant
processes. The elucidation of the molecular mechanisms of the ethylene-signaling and ethylene-
response pathway in Arabidopsis might provide a framework for understanding how other plant species
sense and respond to ethylene.
Hongjiang Li, Hongwei Guo

|
Engadget -
1 days and 20 hours ago

The Large Hadron Collider is no
stranger to setting energy records: back at the end of November it
broke the 0.98 TeV record by hitting the 1.18 TeV mark. Well, the problem beleaguered
collider's just handily surpassed itself -- this time with a truly stunning 3.5 TeV -- with beams
of protons on record as having circulated at 3.5 trillion electron volt. Now, we're not scientists
or anything, but that sure is a lot of volts! CERN's moving on later this week and will begin
colliding the beams so they can check out the tiniest particles within atoms in the hopes of
finding out more about how matter's made up. We look forward to hearing all about that, too -- but
until then, we made do by reading the source over and over.
LHC breaks its own energy record, still less powerful than Lady GaGa originally appeared on
Engadget on Fri, 19 Mar 2010 14:14:00 EST. Please see our
terms for use of feeds.
Permalink | Physorg | Email
this | Comments
|
Mashable! -
1 days and 21 hours ago
This post originally appeared on the American Express OPEN Forum, where Mashable
regularly contributes articles about leveraging social media and technology in small
business.
Google Apps for business has a number of
benefits over traditional business IT and desktop software. Using the full suite essentially
places all of your data and entire workflow in the cloud, meaning you can access it all anywhere,
any time, from any Internet connection.
At $50 per year per user, the fully integrated apps system is certainly cost-effective, and even
adding the free versions of Gmail, Calendar, and Google Docs into your workflow can keep your employees
coordinated.
For more casual users, or even those who might not be acquainted with Google Apps, here’s a
guide to how the software can benefit your small business.
Gmail
The many advanced features of Gmail really make it a
leap forward in the web-based e-mail space, and a lot of these are ideal for business.
If you’re not ready to take the full plunge into the paid Google Apps suite, you can still
configure Gmail to function as your business e-mail client through your existing domain name by
following the steps outlined in my post, “How to Set Up Gmail as Your Business E-mail Client.”
The first big advantage of Gmail, like all the apps discussed here, is that it functions
in the cloud. You don’t have to worry about downloading messages to multiple
locations or syncing various devices. Your inbox will look the same from any web or mobile
connection. And with 25 gigs of e-mail storage per user (with a paid apps account), it’s
unlikely you’ll ever have to clean your inbox or delete old messages.
Gmail works a bit differently than traditional desktop clients and webmail services in that
conversations are “threaded.” This means that e-mails with the same
or related subject lines are grouped together in a thread so you can see all the messages sent
and received on a topic in one place. When a new message is received, the entire thread is bumped
to the top of your inbox, making tracking complex and multi-party conversations easy.
Gmail also has a chat feature built right into the interface that lets you send
a quick update or discuss a project with an employee if you’re not in the same office.
Chats are also stored in Gmail so that you can search and refer to them later.
Google search, the asset that started it all for the company, is of course built
right into Gmail, which makes finding information from e-mail conversations (even very old ones)
extremely efficient.
Additionally, Gmail Labs offers some extra settings for your inbox that can be extremely valuable
for business use:
-
Signature Tweaks puts your e-mail signature before the quoted text in a reply
the way that Outlook would.
-
Default ‘Reply to All’ allows you to reply to group e-mails with
one click, instead of from a drop-down menu.
-
Forgotten Attachment Detector will notify you if you’ve mentioned an
attachment in an e-mail, but forgotten to add one.
-
Undo Send gives you a few seconds after sending a message to click
“undo” in case you forgot something, or sent it to the wrong party by mistake.
-
Title Tweaks is a great feature that puts your unread message count first in
the title of the inbox web page. If you have many windows open while you’re working,
you’ll still be able to see when new messages arrive.
Google
Docs
Google Docs is a web-based suite for word processing, presentation building (similar to
PowerPoint), spreadsheets, and web forms. All the work is done in a web browser, and all the data
is saved in the cloud.
The software can be a bit quirky at times, which may frustrate users of more stable products like
Microsoft Office, but the payoff in online storage, shareability, and collaboration options may
be worth the adjustment for many small businesses.
Because the data is online, streamlined document sharing and collaboration are
big perks with Google Docs. Any file you’re working on can be shared with individual team
members, or the entire group within the apps system. You can also set permissions for specific
users to view and edit documents. And, multiple users can simultaneously view and edit documents,
which can be useful for real-time collaborative projects or presentations during conference
calls. You can also grant permission for those outside your office network to view and edit
documents, which can be especially useful for sharing information and presentations with clients
or colleagues.
As you create and share documents, your Google Docs dashboard may start to get a little messy. Be
sure to create folders to keep your work organized just as you would on your
desktop. You can also share entire folders if you need to collaborate on multiple documents
related to the same project.
Calendar
Google Calendar provides an efficient and intuitive way to keep appointments and events synced
across your entire business. With calendar sharing and permissions (similar to
those in Docs), you can add other employees’ calendars to your own, and vice versa, in
order to see and manage the big picture of your team’s time.
For example, if an executive has an assistant, their calendars may be shared so that the
assistant could manage his boss’s appointments remotely from his own account. It’s
also a smart tool for coordinating meetings, calls, and shift staffing for multiple employees to
avoid scheduling conflicts. Sharing multiple calendars with one “master calendar”
creates a color-coded scheduling table for the coordinator that updates automatically when users
make changes or additions.
The Calendar app can also be used to create events through Gmail. By adding your
employees’ e-mail addresses to an event, they will receive an invitation to respond.
Responding ‘yes’ automatically adds a shared event to your calendar that each invitee
can view and add notes to. It’s a smart way to coordinate meetings and keep everyone in the
loop.
Google
Sites
Google Sites is a drag-and-drop web development tool that you can use within your
business’s apps to create online information hubs for employees. The
websites you create exist within your Google Apps domain, can be public or private, and
permissions for employees to add, change, and contribute information can be set from the main
account.
Beyond simply being a WYSIWYG web editor, Sites makes it easy to integrate data from
other Google Apps into dynamic pages that team members can use to collaborate on
projects. Integrating spreadsheets or data charts from Docs, a deadline schedule from Calendar,
and team-specific messages from Gmail could essentially create a one-stop project dashboard full
of dynamically updating information.
Sites here can be purely functional or informational, or with the aid of some built-in templates
or a good designer, a full-fledged dynamic public website for your business that
team members have easy access to.
Google
Groups
Google Groups have long been public forums where users across the web gather to discuss specific
interests or get technical support. Groups for business brings that same functionality into your
private internal network.
E-mail can sometimes be cumbersome when coordinating a team. When you need a central space to
collect ideas and share documents (but you’re not interested in building a web page in
Sites), Groups offers a solution.
Employees can create discussion groups on their own and subscribe, either by
e-mail or via a Groups dashboard, which lists new posts like a news reader.
Rather than e-mails going out to individual inboxes, a group thread remains visible to all of
your subscribed team members, and users can go back to it for reference, to add more information,
and even share docs and calendars.
Using Groups for business discussions and project management creates a communal and
searchable database of information that employees can go back to whenever needed.
Google Apps
Marketplace
Google’s recently launched Google Apps
Marketplace allows developers of other business web apps to integrate their offerings with
Google and sell software directly to Google Apps users. The marketplace currently has over 50
partners, including Intuit, Zoho, and Aviary. This additional space for third-party software
means that Apps users will have even more options to tailor their suite for specific business
purposes.
Smart Integration Across the Board
While each app has worthwhile features, perhaps one of the best advantages is the way that they
all integrate with one another. Documents and appointments can be easily shared via e-mail, and
your inbox can be used as a portal for productivity via embeddable widgets, chat, and other
notifications.
If your small business is ready for a web-based, collaboration-minded IT solution, Google Apps is
certainly a cost-effective way to go, and you can investigate the free versions simply by signing
up for a Gmail account to determine if the suite is right for your workflow.
More business resources from Mashable:
- HOW TO: Choose a News Reader for Keeping
Tabs on Your Industry
- 4 Elements of a Successful
Business Web Presence
- HOW TO: Implement a
Social Media Business Strategy
- HOW TO: Measure Social Media
ROI
- HOW TO: Use Social
Media to Connect with Other Entrepreneurs
Image courtesy of iStockphoto, CostinT
Tags: business, gmail, Google,
google apps, Google Calendar, google docs, google labs, List, Lists,
productivity, small business


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Read/WriteWeb -
1 days and 22 hours ago
As one of ReadWriteWeb's
iPhone users, I'm always looking for new applications to try out. Some get downloaded for a day
and then deleted right away, others slowly inch their way closer to my homescreen. Even rarer are
the ones that become actively used on a regular basis. Occasionally, we like to share our
findings regarding our favorite new apps. (See, for example, last month's list here).
Although I can't guarantee that all of the ones on the list below will become favorites
forever, they piqued my interest enough to get a coveted spot on my iPhone this month.
Let us know what you think about their potential for long-lasting success.
Sponsor
1. Miso
I've been playing
with Miso off and on for a week or so. Dubbed a
"Foursquare-Like App for Homebodies" by yours truly, this app lets you "check-in" to the TV shows
and movies you're watching and earn badges. While I like the idea, I've found that the app
suffers from the lack of an easy way to find and follow other users. That leaves us TV-watching
"stay-at-home" folks feeling a little too isolated when already taking part in a rather
non-social, non-interactive activity. However, if the app can improve the ability to find and
follow other like-minded entertainment consumers, there's potential for a fun "niche use" type of
app here. (Review: Miso: A
Foursquare-Like App for Homebodies)
2. MediaServer
MediaServer seems so promising,
but I've had trouble getting all aspects of it to work properly. The app is designed to be an
easy way to view your iPhone media on your TV set by way of a Media Center-type hardware device
(XMBC, Boxee, etc.) or game console (PS3, XBox 360). And it is easy to use. You install
the app, launch it, and boom!, your media console sees your iPhone - no configuration
required. As far as viewing user-created videos or photos, the app excels. But streaming music or
video? Not so much. Due to varying degrees of DRM applied to the files themselves and codec
support on the hardware device, playing media on your TV is harder than it should be. (I tried
with the Xbox in my tests.) Whether it's the app that's to blame or the hardware, I can't tell.
However, MediaServer did become a great way to do iPhone photo slideshows on the TV and that
alone is keeping it on my phone for now. Hopefully the rest will be improved in time.
3. Sticky Bits
The RWW bloggers who attended the recent SXSW festival have come back raving
about the barcode-scanning Stickybits app (iTunes link).
The app, which debuted at the conference, goes hand-in-hand with the online service that lets you
either print your own barcodes or buy pre-made stickers which you can then associate with
real-world objects. Using the Stickybits iPhone application, anyone encountering these stickers
in the wild can scan them to discover whatever data theyv'e been associated with. Will Stickybits
actually stick around though? It's too soon to tell, but it sure is fun to play with in the
meantime. (Review:
Stickbits: Portal to Another Dimension or Graffiti for Nerds?)
4. Siri
Although not
brand-new, the Siri app which debuted in February on the iPhone is
rapidly becoming one of our all-time favorites and therefore has to make this list again. If you
have not installed Siri yet, do so now! Built with artificial intelligence technology, Siri
functions as a personal assistant which can provide information on a variety of topics from
weather to movie listings to restaurants, events and more. You can either type into the app's
search box or speak your query to get started. And the more you use it, the smarter it gets. The
voice recognition works well, too, although it never understood "Alice in Wonderland movie" no
matter how many times I said it. (Maybe it already knew I wouldn't like that movie?) We'll give
it a pass there, though - voice recognition is a tough nut to crack. Still, the intelligence of
this app will soon have you relocating the apps it replaces (movie listing apps, restaurant
finders, etc.) to back screens of the iPhone. (Review: Siri:
Your Personal Assistant for the Mobile Web)
5. Tweeb
Obsessed with ego-tracking
your Twitter stats or tasked with managing a corporate account of some kind? Then Tweeb's new Twitter analytics tracker
(iTunes link) is a handy app to have. For $1.99, you get access to real-time, on-demand
statistics including tweet counts, follower counts, retweets, mentions and clickthroughs on your
tweeted links. You can also use the app to tweet, manage your friends, block or unblock users,
view Twitter profiles, view your following lists and manage multiple Twitter accounts. The data
is presented in clean, easy-to-read layouts and there is even a history section so you can
measure your growing influence over time. Well worth a couple of bucks if you access this data on
a regular basis!
6. Buzzie
The first app
to access Google Buzz natively is pretty great, but I'll admit that I'm more likely to switch
over to Buzz from Google Reader's mobile website than launch a standalone app. If the iPhone had
app multitasking though, that would be a different story. Still, Buzzie has a few standout
features - photo-sharing and photo browsing, most notably. It also feels "a lot snappier" than
Google Buzz's web app, noted Frederic earlier this month during his demo. (Review:
Buzzie:
The First Native Mobile App for Google Buzz)
7. SpringPad
Part of Springpad's service, this Evernote competitor functions as a mobile
note-taking and reminder app. Similar to Evernote's offering, you can write a note or snap a
photo to remember something (which is then added to your online account), but it also introduces
barcode-scanning as another way to "remember" an item. You can use the app to access all your
saved data, too - handy for accessing shopping lists, recipes and restaurants you want to try
while you're out and about. (Review:
Springpad Takes on Evernote with Semantic Technology, Barcode Scanner)
Honorable Mentions
Other apps getting demoed on our iPhones include the following:
-
Brizzly for
Twitter: Will we leave Tweetie 2 for this new Twitter iPhone app? It could happen!
-
Feathers: Want to have a
little fun with your tweets? Feathers lets you decorate them with symbols, icons or even post
them upside-down.
-
Notifio: Just launched, this app tries to bring Android-style
notifications to one central place on the iPhone, but it's dependent on others to use its API
to do so. If successful, it could be amazing...but that remains to be seen.
You can see all the apps on my iPhone courtesy of AppsFire
here.
Discuss


|
Media Matters for America -
1 days and 23 hours ago
Following the Congressional Budget Office's score of the health care reform reconciliation
package, Fox News has attempted to portray the nonpartisan CBO as untrustworthy and unreliable.
By contrast, after the CBO gave a "favorable" score to the GOP health care plan, Fox praised the
office as "nonpartisan" and advanced false GOP claims about the CBO's findings.
Fox News does damage control, attempts to portray CBO as untrustworthy and unreliable
Beck mocks CBO score of health care reform: "Well, that's a party in my
pants." On the March 18 edition of Fox News' Glenn Beck, Beck asked, "How would the CBO numbers even make any
difference? You know, 'Only 900 and' -- what is it -- '$954 billion.' Ooh. Well, that's a party
in my pants. Thank you for sending that one by. How does that make a difference?"
Doocy: "[C]an you really rely on the numbers that the Congressional Budget Office
comes out with?" On the March 19 edition of Fox News' Fox & Friends,
co-host Steve Doocy claimed, "Democrats
say it will reduce the deficit by more than $100 billion over the first decade." After guest host
Dana Perino responded by saying, "Well, but there are other members who say that it actually will
cost $2.4 trillion over the 10 years once you add it all up," Doocy asked, "Because, can you
really rely on the numbers that the Congressional Budget Office comes out with?"
Perino: "[C]an we trust these numbers?" Introducing an interview with Rep.
Anthony Weiner (D-NY) on the same edition of Fox & Friends, Perino said, "Nine
hundred and forty billion dollars over the next decade. That's the preliminary price tag for the
Democrats' health care bill, according to the Congressional Budget Office. It also says the plan
will cut the federal deficit by $130 billion in that time, but can we trust these numbers?"
Weiner said the score "came out really better than we thought it would. It was a great savings
number, and so the deficit hawks now have things that they can point at and say, 'You know what?
This really does save money." Perino then asked him, "But do you think ... that those numbers can
be trusted later on?"
Johnson Jr.: "I don't expect or anticipate that their numbers are real."
On the same edition of Fox & Friends, co-host Brian Kilmeade said that the "average
person" would say, "[I]f a plan costs $940 billion, tell me how I'm saving 130 billion. So it
doesn't make any sense." Fox News legal analyst Peter Johnson Jr. then noted that Perino had
asked, "Do we really trust these numbers?" and claimed that "if you read carefully the latest CBO
things, they say, 'Well, we don't usually project out another 10 years.' And there's so many
variables and so many wiggle words that I don't expect or anticipate that their numbers are
real." He later said, "I think we're being spun."
Hannity calls CBO score "budgetary gimmicks and tricks." On the March 18
edition of Fox News' Hannity, host Sean Hannity called the CBO score of the health care
bill reflected "budgetary gimmicks and tricks" and said that it is "[f]lat-out dishonest" that
the score didn't contain separate legislation that cancels scheduled cuts in Medicare payments to
doctors. After guest Rep. Eric Cantor (R-VA) claimed "the only way that [Democrats] pay for those
additions is to reduce seniors' health care benefits on their Medicaid or raise taxes," Hannity
responded, "[W]hy would the CBO not highlight this to give a truly educational, informational,
you know, scoring of this to the American people?"
Hemmer asks Juan Williams "do you believe" the CBO long-range forecast. On
the March 18 edition of Fox News' America's Newsroom, Fox News contributor Juan Williams
called the CBO score a "deal-maker"
because it will "reassure those independents and, by extension, those Democrats that have been on
the fence because they are deficit hawks" because of the deficit reduction. Co-host Bill Hemmer
then said to Williams, "That's 20 years out. You've lived in Washington a long time. Do you
believe that?"
Fox Nation headline: "CBO Score Called a 'Lie.' " On March 18, Fox Nation
posted a National Review article under the headline "CBO Score Called a 'Lie.' "
From Fox Nation:
By contrast, Fox News touted "favorable" CBO score of the GOP health care bill
Fox's Shively touted "favorable" CBO report on GOP health care bill and advanced
false GOP claim that GOP plan would lower premiums more than Democrats' plan. On the
November 5, 2009, edition of Fox News' Fox & Friends, contributor Caroline Shively
adopted the GOP spin by reporting, "Now, on the other side of the aisle, Republicans have gotten
favorable reports from the Congressional Budget Office on the cost of their health care bill. GOP
lawmakers say that means premiums for millions of families will be almost $5,000 lower under
their plan, compared to the cheapest plan in the Democrats' exchange." In fact, the $5,000
difference Shively cited ignored premium caps in the House Democrats' plan. As Media Matters
for America has noted, because
the Democrats' health care bill provides premium caps on a sliding scale based on income, the
lowest amount that a family would have to pay in premiums is significantly less than the GOP
alternative.
America's Newsroom attributes Republican talking point to CBO. On the
November 5 edition of America's Newsroom, host Martha McCallum claimed, "The nonpartisan
Congressional Budget Office is saying that the Republican bill ... will carry lower costs for
Americans. The CBO estimates that health insurance premiums would be nearly $5,000 cheaper under
the Republican reforms than the Democratic ones." In fact, the CBO never made that claim. The
comparison was based on calculations done by Republican members of the House Ways and Means
Committee. From America's Newsroom:
Fox & Friends report obscures that GOP plan wouldn't cover uninsured,
wouldn't significantly lower premiums, would reduce deficit less than Democrats' plan.
Shively's Fox & Friends report ignored that the GOP plan would not cover most
uninsured Americans. Shively also did not report that the CBO estimates indicate that House
Democrats' bill lowers the deficit more than the GOP's proposal.


|
CNN.com - WORLD -
1 days and 23 hours ago
A video clip which shows an office worker opening a Kit Kat chocolate bar and finding an
orangutan's finger has been re-posted on video-sharing Web site YouTube, a day after it was removed
at the request of food giant Nestlé. 
|
Planet Ubuntu -
1 days and 23 hours ago
 Invitation
to Participate
in Ada Lovelace
Day
on
March 24,
2010
On Ada Lovelace Day, the Ubuntu Women
Project is encouraging you to blog about the achievements of women in technology and
science.
We are especially asking you to highlight women within the Ubuntu Community whose
achievements and contributions have inspired you or others. So between now and
next Wednesday ( yep it's just around the corner) think about 1) who you want to write
about - it can be more than one person 2) write your post, 3) schedule it for publication,
and let's tell the world the about awesome achievements and contributions of women within the
Ubuntu Project and Community.
If you haven't done so already please visit the Finding Ada
website and make your pledge to Blog on March 24th, 2010. 
|
Read/WriteWeb -
2 days ago
A group of researchers have proven
something we already expected to be the case: your Twitter follower count is somewhat of a
meaningless metric when it comes to determining influence. To reach this conclusion, the
researchers examined the Twitter accounts of over 54 million active users, out of some 80 million
accounts crawled by their servers. They then went on to measure various statistics about these
accounts, including audience size, retweet influence and mention influence. The conclusion? Those
with the largest number of followers may be "popular" Twitterers, but that's not
necessarily related to their influence. High follower counts don't always mean someone
is being retweeted or mentioned in any meaningful ways.
Sponsor
The findings from this research project have been published in an research paper available
here
on the project's homepage.
How the Data Was Analyzed
The data the researchers had access to is astounding: 54,981,152 user accounts,
1,963,263,821 social (follow) links and 1,755,925,520 tweets. In order to collect this
massive store of data, the researchers contacted Twitter and asked permission to crawl Twitter's
service. Twitter granted them access and white-listed the IP address range for the 58 servers
that were used in the data collection. In total, the crawler was able to scan 80 million Twitter
accounts during the month of August 2009. Only 54+ million of those accounts were actually in-use
at the time, which, in and of itself, is an interesting finding about how many people create a
Twitter account and then abandon it. Only 8% of the active accounts were set to private, so they
were ignored during the data analysis. The researchers also used the Twitter API to gather
additional information about a user's social links and tweets.
The study focused on the largest part of the Twitter network - the "single disproportionately
large connected component," notes the paper, that contained 94.8% of users and 99% of all links
and tweets. Within that large network of "in-use" accounts, the researchers further narrowed down
the data to focus on the "active users." These users where those who had more than 10 tweets and
had a valid screen name that could be retweeted by others. (Interesting - it's possible to have
an account and not a screen name?) That left "only" 6,189,636 active users out
of the initial 80 million to examine.
To measure the influence of these 6+ million users, the researchers looked at how the entire set
of the 52 million users interacted with these active users.
The Three Measures of Influence
After examining the data, the researchers found that the most followed individuals spanned a wide
variety of public figures and news sources and included accounts like CNN, New York Times, Barack
Obama, Shaquille O'Neal, Ashton Kutcher, Britney Spears and others. However, the most retweeted
users tended to be content aggregation services like TwitterTips, TweetMeme, and, interestingly
enough, they counted the tech blog Mashable as an aggregation service, too. Other heavily
retweeted users included Guy Kawasaki, the humor site The Onion and again, The New York Times.
Meanwhile, those users with the most "mentions" - not a direct retweet including the original
content of someone else's tweet, but just a casual mention of their name - were celebs.
These three measures of influence - followers, retweets and mentions - has surprisingly little
overlap when looking at the top influentials. The top 20 lists from these three categories only
had two users in common: Ashton Kutcher and Puff Daddy.
The researchers also examined the ability of Twitter users to influence others. They determined
that the most influential users hold significant influence over a variety of topics, as opposed
to being experts in just one area.
Examining the 233 "All-Time Influentials"
Out of the 6 million active Twitter users, the researchers picked the top 100 users in each of
the three categories. Due to the overlap, there were only 233 distinct users on
these lists. These were dubbed the "all-time influentials." Some of these accounts belonged to
news organizations or celebs, but others were just regular users. Regarding that last group - it
appears that those users who limit their tweets to a single topic are the most likely to increase
their influence scores.
In the end, what the researchers found was that follower count alone is not necessarily a worthy
measure of determining influence. Other factors come into play as well. Although some
heavily-followed accounts are also mentioned and retweeted a lot, just looking at audience size
doesn't reveal an account's ability to influence and impact the Twitter universe.
According to the project's homepage, the researchers are hoping to make the data they collected
available to the community at large. Before doing so, they will discuss it with Twitter in order
to determine that their data sharing plan agrees with the company's policy. They plan to have an
update on this situation - possibly the data itself - by May 2010.
Discuss


|
Mashable! -
2 days ago
Leyl Master Black is a Managing Director at Sparkpr, one of the world’s top independent PR agencies. Leyl has more
than 15 years experience driving high-impact communications programs for emerging technology
companies.
While more than three million businesses, brands and celebrities have created Facebook Pages, many are struggling to figure out
how best to use them. Companies are finding that even when they keep their pages updated with
fresh content, they still aren’t seeing steady growth in their fan base.
And yet there are many brands who’ve surpassed the one million fan mark, while their peers
have languished in the thousands. What’s their secret? These companies have figured out how
to move from “broadcast” mode into engagement. They have engaged people so well that
their fans even invite others along for the ride.
Here are four ways that savvy Facebook marketers are using the medium to engage with their fans.
1. Ask Their Opinion
If you post something on your Facebook Page, you might generate a good number of comments. But if
you post your content in the context of a question, you provide an easy call to action. With a
question, you engage people’s egos and provoke viral distribution of your content —
everyone loves to share their opinion!
At the DigiDay: Social conference
this month, social media marketing application developer Fan Appz highlighted an example of how a simple question can boost
engagement. One of their customers — a leading video content provider with over 300,000
Facebook fans — routinely posts videos on their Facebook Page. The company found that when
they paired videos with a question, video plays jumped by a whopping factor of 7 to 10. This
simple yet effective strategy also generated 100 times more Facebook media impressions, as people
posted videos to their walls in the context of their response to the question.
The NBA has also adopted this approach, issuing a steady stream of “Top Five” polls
and other engaging content that has propelled the organization to top the two million
fan mark, an unprecedented number for a sports league on the social networking site. The NBA
routinely invites fans to rank their top five shooters, point guards and more. During the 2009-10
NBA season, their Fan Page generated nearly 500 million status update impressions and more than
six million video views.
2. Test Their Knowledge
Consider testing people’s knowledge with a fun, relevant quiz, and even tying the results
to a giveaway or promotion (more on that later). A clever quiz is not only entertaining, but also
lengthens the time a user spends engaged with your brand.
One company embracing this approach is Molotov, a digital marketing agency whose clients include
comedians such as George Lopez, David Spade and Jamie Kennedy. Molotov worked with George Lopez
to create quizzes such as How Well Do You Know George Lopez? to push his fan base over the one
million mark and drive viewership for his TV show.
In another Molotov program to promote a client’s new TV show, the company ran a series of
quizzes about the celebrity in conjunction with a sweepstakes for signed merchandise. The quizzes
were tests of knowledge about the comedian, his comedy, his routines, even about what happened on
last week’s show. Giving people the opportunity to test their knowledge got them into a
competitive mode and provided an additional incentive to share their results with friends. In the
span of a little over a week, the campaign drove over 12 million brand impressions — and
the premiere of the show was the highest rated show on the cable network for the year.
3. Pair Promotions with Content
While a contest or sweepstakes may get you some e-mail addresses, simply posting these on your
page provides limited incentive to share with friends or even to participate. The way to boost
participation is by tying the offer to content. People taking a brand-related quiz are great
targets for your message. They may already have an affinity for the brand, so this is the best
time to make them an offer.
In the example mentioned above, Molotov gave fans a chance to enter a sweepstakes to win signed
merchandise — but the offer was made within the flow of the quiz. This strategy resulted in
a 50% conversion rate. For every ten fans who tested their knowledge, five signed up to
participate in the promotion, generating over 30,000 sign-ups for the weekly e-mail blast to
promote the show.
The offer doesn’t even have to be big. Before the Super Bowl, the NFL ran a How Well Do You Know the
NFL? quiz, with one lucky participant selected to receive a $50 gift card to NFLshop.com. Over 10,000 people took the quiz. If you
estimate that each participant has 200 friends, that’s a possible two million impressions
in the news feed with a relatively small giveaway.
4. Thank Your Fans
Giving your fans something of value — whether it’s as simple as a coupon, or as
flashy as tickets to the Tonight Show — is a great way to show that you appreciate
their continued support.
But what about picking one fan at random to get something really special?
The NBA again shows that they are on the leading edge. This brilliant strategy taps some of their
biggest stars to record personalized video clips thanking select fans. Here’s a picture of Shaq
thanking fan #385. If you’re an NBA fan, you could be next!
Put These Ideas Into Action
You don’t have to be a major brand like the NBA to turn your Facebook Page into an engaging
destination. Any business can take these ideas and get creative. A restaurant could pair a quiz
about famous restaurant movie scenes with a $100 gift certificate sweepstakes, or a Ford
dealership could run a poll gauging people’s reactions to the Toyota recall news and give
away interest-free financing to one lucky winner. The trick is to think about what your users
would be interested in, what’s trendy or fun, then try it out.
In what ways are you engaging with your Facebook fans?
More Facebook resources from Mashable:
- 5 Fantastic Facebook Fan Page
Ideas to Learn From
- HOW TO: Build a Facebook
Landing Page for Your Business
- HOW TO: Block FarmVille on
Facebook
- How Facebook Can Become a Money
Making Machine
- 10 Musts for Marketing to
Women on Facebook
Tags: business, celebrities, engagement, facebook, facebook fan page, facebook fan pages, Facebook Lists, List, Lists,
NBA, quiz,
small business


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