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Global shipments of GPS-enabled GSM/WCDMA handsets increased 92% in 2009 to 150 million units,
according to a new research report by Berg Insight. Growing at a compound annual growth rate (CAGR)
of 38.7%, shipments are forecasted to reach 770 million units in 2014. Adoption of GPS technology
started in the smartphone segment where it is now essentially a standard feature on all new models.
Berg Insight anticipates high attach rates of GPS also in new low-cost smartphones about to enter
the market. In addition, GPS will become more common in mid-range featurephone models during 2010.
Starting next year, users can also expect gradual improvements in location performance in handsets.
Almost every day a new person, someone I have never met or corresponded with, writes me an email in
response to my blogs or one of my books. I do my best to answer such writers if the tone and spirit
of their correspondence is gracious and invites a thoughtful reply. The only exception is when
person simply wants to trash me personally and or attacks my work in a way that offers me no real
room for cordial conversation. In such a case I will usually provide a short answer that expresses
my inability to respond to such a letter since there is no room for dialog and mutual respect. I
desire dialog and mutual respect and always offer the same back wherever I can.
Harshly negative responses once deeply troubled me. I still struggle with this kind of criticism.
It leaves me feeling fragile and defenseless. It is humiliating. I was too sensitive while I was a
pastor, and I have had a hard time dealing with the same kind of thing over the last nineteen years
as the president of ACT3 and as a published author. Everyone who teaches and writes invites
criticism. I expect it. What I did not but have finally come to expect sadly, is the angry person
who simply wants to tell me off or makes a “case” for why my life and ministry is a
disaster. I recall the late Vance Havner saying that every minister needed “the heart of a
saint and the hide of a rhinoceros.” I am quite sure I have neither in abundance but I will
press on praying for them both till my numbered days are finished.
A few days ago
I receive a very interesting email regarding my posts last year on the late Keith Green. While I
never knew Keith I loved him and feel he was, as I said at the time, the “real deal.”
He made more than a few mistakes but they were made because he was young and filled with real zeal.
Such zeal frightens folks, but some people need to be frightened now and then. Lethargy grips far
too many of God’s people, and the church will never be bold and obedient until the prophets
are heard. Keith was a prophetic voice. But he was more, as I noted in my articles. My
“new” friend wrote the following to me (slightly edited by me):
I have to admit that I had not heard of you until recently. For this I am sorry. I just came
upon a couple of articles you have on your blog site about [the late] Keith Green. I thought these
were wonderful. I'm 49 years of age and was raised in the heart of the Jesus Movement at Maranatha
Church in Portland, Oregon. Maranatha Church, along with Calvary Chapel in Costa Mesa, California,
were probably the first two Jesus Movement "mother" churches of the late 1960's. I was there as a
child among all those converted hippies. This experience gave me a broad context that some who have
only heard about these events—but who weren’t actually
there—or some who have since seen [the more recent] copies of real revival, do
not have. I later bumped into Keith Green hearing him for the first time at Jesus Northwest. I'm
thinking this was around 1977. This was amazing stuff. But like you I was concerned all along the
way—deeply concerned to the point of considering writing him a letter but
figured he'd not have gotten it—a big mistake I now realize. I remember seeing
how strident he was at a concert that I attended in Vancouver, Washington. He was right on with
what he said but when he apologized in the last article that came out before his death it was as if
Keith had finally figured out grace. "I'm sorry if I blew you away with my lack of love,” he
wrote. I loved that humility. It was like a glow came over him—and then I saw
what I had seen at Maranatha—zeal with love; with so much more love than zeal.
To get rid of the darkness we can rail against it or we can turn on the light!!
I still love Keith Green. His music seems so different than his teachings, or at least the words
that I recall—his music isn't angry. Thank you for publicly calling Keith
Green's former teachings into question—it's a very good thing to hear. I am sure
that it is going to be hard for some people to hear this message since many never saw the zeal with
love that I got to see at Maranatha—it was either a dry church or the passion of
Keith Green for so many people in that context.
Rev. Armstrong I really do appreciate your writing. It was fun to read what you said. I want to
thank you for your measured and balanced approach to Keith Green. It is so sad that he wasn't able
to live to be a fully grown-up Christian. I wonder, along with you, what would have happened if he
had lived and matured. I suspect that he would have been a very sweet man who taught the love of
Jesus and more or less ignored the condemnation of those who at one time he had said were playing
church. After all what's the point eventually? It seems to me that it is much better to be an
example of balance and to be [more] like Jesus in the world. One former Foursquare pastor told me
one of the greatest things I've ever heard as a Christian: "The most releasing day was when I found
out I wasn't the Holy Spirit." I love that thought so much—I imagine Keith Green
would have really figured that out too had he lived a little longer.
After I received this letter I wrote the author and asked permission to print an edited
and anonymous version of his words to me. He wrote back another thoughtful and engaging letter.
This reflects something of the breadth of readership on this site. It is a breadth I intentionally
cultivate and desire. I welcome readers like my friend. Here is what he wrote in his second
letter:
Thank you also for taking the time to write to me after I wrote to you. [You may use my thoughts
anonymously.] One thing happened at the Keith Green Vancouver, Washington, concert that a friend of
mine remembers but I don't is that apparently Keith got down on his knees during the concert,
raised his arms to the heaven and proclaimed "Oh praise IT.” This was his commentary on the
"I Found It" public relations campaign [directed by Campus Crusade for Christ across America] going
on at that time. That was so funny [also insightful and courageous] but I've never heard it
mentioned by anyone. A friend told me this story and said he was there with a friend whose father
was on the national "I Found It" board. He said this guy wasn't amused!! That incident sums up
Keith Green and his biting commentary on the times. He was really unvarnished.
Thank also for telling me about your site(s) and your new book. My vision has been to [move in the
direction of] so much of what you are doing in your speaking and writing. I'm not sure when or
exactly how those doors will open but I hope I'm ready when/if they do. It's exciting to talk to
you and hear and see what you are doing. I'm one of those odd Christians who is a Democrat
[something like] the teacher and author Tony Campolo but I am sometimes saddened by what I hear,
not necessarily from him but from the other people on the Christian Left [who are evangelicals] . .
. I wish they would build bridges with the Christian Right. The hard thing for the Right I think is
that they just don’t know the difference—they just don't understand
compassion in a [real] works kind of way and I believe we can teach them by being sweet to them. I
think bridges can be built. My dad was a pioneer in migrant-rights worker movement back in the
1950's and then worked in the War on Poverty thus I feel so blessed to have seen what can be done
to change people's lives by such action— something I think my friends on the
Christian Left are trying to do—but honestly I don't quite understand either
extreme among Christian evangelicals. I think of something that shocked me when I really realized
it. At the end of the age, when we stand before the Lord, he is not going to ask "How many people
did you lead to me?" This was shocking to me as a born again guy who has always been taught that
bringing people to the Lord was the critical thing, which I do still believe. But Christ is going
to ask us about our involvement in social justice. I was hungry and you fed me. It's such a
shocking difference in spiritual priorities from what I usually hear in church. This is rather
weird isn't it?
Thanks again. It's really fun to meet a new person who is insightful and is looking to teach and
lead Christians into thinking and to balance. If there's anything I can do to help you let me know.
I look forward to seeing more of your work and thoughts in your writings.
I hope this is the beginning of a relationship even if it is only via the Internet. This is not a
virtual friendship any more than Christians who exchanged letters in centuries past, and never met
face-to-face, had real friendships for the kingdom of God. I welcome my new friend into the circle
of those who know and love me. I need his insights and his prayers. I need your insight and prayer
too if I am to do a better job in my work for the whole church.
Let's cut the glamour. I would like to meet someone with a painful past. If you have had a boring,
normal life, please don't reply. I like people with depth and insight and an ability to deal with
life.
The endosymbiotic theory proposed that mitochondrial genomes are derived from an
alpha-proteobacterium-like endosymbiont, which was concluded from sequence analysis. We rebuilt the
metabolic networks of mitochondria and 22 relative species, and studied the evolution of
mitochondrial metabolism at the level of enzyme content and network topology. Our phylogenetic
results based on network alignment and motif identification supported the endosymbiotic theory from
the point of view of systems biology for the first time. It was found that the mitochondrial
metabolic network were much more compact than the relative species, probably related to the higher
efficiency of oxidative phosphorylation of the specialized organelle, and the network is highly
clustered around the TCA cycle. Moreover, the mitochondrial metabolic network exhibited high
functional specificity to the modules. This work provided insight to the understanding of
mitochondria evolution, and the organization principle of mitochondrial metabolic network at the
network level. Xiao Chang, Zhuo Wang, Pei Hao, Yuan-Yuan Li, Yi-Xue Li
Publication Date: 2010 Mar 18 PMID: 20237569Authors: Andersen, C. B. - Madsen, M. - Storm, T. -
Moestrup, S. K. - Andersen, G. R.Journal: NatureCobalamin (Cbl, vitamin B(12)) is a bacterial
organic compound and an essential coenzyme in mammals, which take it up from the diet. This occurs
by the combined action of the gastric intrinsic factor (IF) and the ileal endocytic cubam receptor
formed by the 460-kilodalton (kDa) protein cubilin and the 45-kDa transmembrane protein amnionless.
Loss of function of any of these proteins ultimately leads to Cbl deficiency in man. Here we
present the crystal structure of the complex between IF-Cbl and the cubilin IF-Cbl-binding-region
(CUB(5-8)) determined at 3.3 A resolution. The structure provides insight into how several CUB (for
'complement C1r/C1s, Uegf, Bmp1') domains collectively function as modular ligand-binding regions,
and how two distant CUB domains embrace the Cbl molecule by binding the two IF domains in a
Ca(2+)-dependent manner. This dual-point model provides a probable explanation of how Cbl
indirectly induces ligand-receptor coupling. Finally, the comparison of Ca(2+)-binding CUB domains
and the low-density lipoprotein (LDL) receptor-type A modules suggests that the electrostatic
pairing of a basic ligand arginine/lysine residue with Ca(2+)-coordinating acidic
aspartates/glutamates is a common theme of Ca(2+)-dependent ligand-receptor interactions.post to:
CiteULike
Neuro-axonal degeneration occurs progressively from the onset of multiple sclerosis and is
thought to be a significant cause of increasing clinical disability. Several histopathological
studies of multiple sclerosis and experimental autoimmune encephalomyelitis have shown that the
accumulation of sodium in axons can promote reverse action of the sodium/calcium exchanger that,
in turn, leads to a lethal overload in intra-axonal calcium. We hypothesized that sodium magnetic
resonance imaging would provide an indicator of cellular and metabolic integrity and ion
homeostasis in patients with multiple sclerosis. Using a three-dimensional radial gradient-echo
sequence with short echo time, we performed sodium magnetic resonance imaging at 3 T in 17
patients with relapsing–remitting multiple sclerosis and in 13 normal subjects. The
absolute total tissue sodium concentration was measured in lesions and in several areas of
normal-appearing white and grey matter in patients, and corresponding areas of white and grey
matter in controls. A mixed model analysis of covariance was performed to compare regional tissue
sodium concentration levels in patients and controls. Spearman correlations were used to
determine the association of regional tissue sodium concentration levels in T2- and T1-weighted
lesions with measures of normalized whole brain and grey and white matter volumes, and with
expanded disability status scale scores. In patients, tissue sodium concentration levels were
found to be elevated in acute and chronic lesions compared to areas of normal-appearing white
matter (P < 0.0001). The tissue sodium concentration levels in areas of
normal-appearing white matter were significantly higher than those in corresponding white matter
regions in healthy controls (P < 0.0001). The tissue sodium concentration value
averaged over lesions and over regions of normal-appearing white and grey matter was positively
associated with T2-weighted (P ≤ 0.001 for all) and T1-weighted (P ≤
0.006 for all) lesion volumes. In patients, only the tissue sodium concentration value averaged
over regions of normal-appearing grey matter was negatively associated with the normalized grey
matter volume (P = 0.0009). Finally, the expanded disability status scale score showed a
mild, positive association with the mean tissue sodium concentration value in chronic lesions
(P = 0.002), in regions of normal-appearing white matter (P = 0.004) and
normal-appearing grey matter (P = 0.002). This study shows the feasibility of using
in vivo sodium magnetic resonance imaging at 3 T in patients with multiple sclerosis.
Our findings suggest that the abnormal values of the tissue sodium concentration in patients with
relapsing–remitting multiple sclerosis might reflect changes in cellular composition of the
lesions and/or changes in cellular and metabolic integrity. Sodium magnetic resonance imaging has
the potential to provide insight into the pathophysiological mechanisms of tissue injury when
correlation with histopathology becomes available.
The shortest way to describe this is that Google is no longer a verb. It's becoming
a noun. Not just the few clicks to find information, but the information itself and the
experience surrounding it.
Today, we get to add Google's chapter to "Will One Company Dominate
the Cloud" introspective series and take a glimpse of the silent revolution from "index" to
"be" that is transforming the company and it's products to the default way to engage the
Internet.
As fate has it, Google done us a big favor in preparing for this piece. The company has launched
an assault on the enterprise with its movement in the Google App Engine, having a
stand-off with China, and negotiating with the EU. And that was
just a bit of Google
news from this week.
Sponsor
Whereas it's a bit more clear where Amazon and Cisco win (our
recent analysis) as they head towards the cloud, with Google it takes a bit more expansive view.
We have to take the focus out a bit, to be able to dial in on the details.
Acknowledgment: Developers are the Products they Build
We recently had the opportunity to sit down with Tim Bray. He has been a key contributor and thought leader
in key areas of interoperability and information design, including his leadership in bringing XML
to the world. He recently announced that he's joining Google and focusing on Android in a
transition from Sun.
Several things struck us about our dialog that we think are key for Google.
First, when Bray described his new job at Google, he talked about what he wanted to do and what
he saw that needed to be done. Within three days of being there, he has a sense of ownership of
the companies products and mission. In some organizations, you may never get such a luxury.
Second, Bray described his opportunity to "roll up his sleeves" and get back in the groove as a
developer on a project he feels passion for. He mentioned his desire to take the open APIs of
Android and expose some of the information in a more portable way, for example to transfer a call
log from one phone to another. A very interesting project, with tangible results. This type of
innovation lives on top of all the work the company has done to make the API exist, and to
attract individuals who are willing to rethink how it should really work.
We think that this is the most interesting thing about where Google is right now. It's "open"
mantra gives the company the ability to see a whole generation into the future of information
channel disruption. And, by bringing in "no holds barred" developers like Bray and a legion of
others, the company is patiently solving problems that many of us don't even know exist.
Lastly, Bray said something that caused us some deep thought.
His comment, "when the Drizzle team was moved into Google, they
just kept working on the their open source project and things stayed nearly the same."
What caused us to pause was that open source development, whether Linux or XML, gives the
developer, as a person, a way to contribute to the world. And it's documented. If the Internet
was the Bible, leading a key open source initiative, is like getting your own chapter in the
book, where time will be the judge of your actions. Much better than your manager alone.
To know that hard work, intellectual capital, libraries are available to the world after the
contract is complete. This really speaks to the artist in us, in a way, the paid open source
developer is using Google as a canvas.
If working at Google offers this emotional spark to employees, it will gain entirely new
efficiencies in solving the big problems, in the context of individual efforts. Maybe this open
source spirit is embedded into Twitter, and is why it works. We like to contribute to our version
of the greater good...and want fans to cheer us on.
What we learned; acknowledgment matters, and connections to the whole population of people is an
amazing vehicle. Google: become an indie rock star - with the strength of grep.
All of the Information on Earth
Google's destiny to become the hub of the worlds information is
intertwined with history. And this comes with artifacts of policy and posturing. To start with,
not everyone agrees that Google should achieve a dominant cloud position. As we're noticing,
stopping it is another matter.
We'd like to suggest that in 2010, the company is not shy about stepping towards its future and
will use its power, technology, and cash to stir it up. Here is our list of organizations in the
world that Google has, is, or will be, continually bumping into in its quest for cloud
information dominance.
China (counties own the filters for the people)
ATT (service providers own consumer on the network)
Penguin (book publishers own the words in the texts)
Visa (financial institutions own the digits in the transactions)
Facebook (social networks know the details)
Amazon (commerce sites own the decision point)
Twitter (owns "what's happening")
Microsoft (owns the computer applications and files)
Open can be a Key to Unlock Doors
We see both practical and strategic reasons that Google has a
deep connection with the open source movement. Strategically, being the new optimized layer,
removing all historic barriers to information give the company more leverage. Practically,
solutions can be built where information is free.
Reviewing a few examples, such as Google Earth, Android, and even GMail and we see that where
there are open protocols and information disruptive products can be built. Once they are built,
the Google wields a significant economic advantage in binding the worlds information assets and
converting them to eyeballs.
Here, we take a quick look at the information assets that Google is investing the global cloud.
Results: Google has moved away from Page Rank to "Closest Object" in it's
default results. What this means is that many businesses today show up as widget in the results
in google with embedded links, maps, and other efficiencies.
Ads: This is perhaps the best known and most valuable insight and unique
asset, who wants to pay for what customer
Realtime index: Google has worked to keep up with Twitter's realtime firehose
Semantic index: The company continues to add more and more microsyntax parsers
into its index, giving more controlled tools for publishers
GMail: It had to be done. And it is monetized.
Documents and files: Google Docs and the Apps Marketplace create a whole new
stream of information about an individual. Private, personal, and shared.
Mobile transactions: This is an interesting sample of where Google's strategy
to build the Android OS pays off in the cloud. Not only does Google get to connect mobile to
the rest of the offerings, but also to be able to dial in on movements, calls, and other
critical tasks in our real-time lives.
Books: Indexing all of them, first is an interesting piece of the strategy to
break apart historic containers of knowledge. Is the book copyrighted? How about the quote?
Browsers: The browser knows a lot. Google's Chrome moves it from being default
search, to being default experience. This was a great example of where access to information
"Faster pages" is the simple value proposition for consumers to switch.
Filters: Protecting companies, trademarks, and interpreting the legality of
free speech. Someone has to do it, if we're all one people.
Health transactions: Google has even taken on one of the most sensitive
challenges, private health information. And, it's connections to legacy systems that prefer EDI
to JSON.
It's clear that Google is making progress. What we've also learned in this review is that the
companies biggest asset - people - may scale to solve problems in lightweight ways that entire
teams and companies haven't been able to in the past. Perhaps being open, or transparent, gives
the company a unique advantage in being prepared for a cloud future.
Is the cloud where the action is?
What verb would you be if you were hired at Google?
This week, documents from Viacom's billion dollar lawsuit against YouTube for copyright
infringement were published, and the three-year-long-and-counting lawsuit has again been brought
to the public's attention. In case you haven't been following the case, here's a quick timeline
of the major events that led up to the lawsuit, and those that occurred since the original
complaint was filed:
May 24, 2005- Viacom subpoenas YouTube for information about a user who uploaded
clips from Paramount Pictures' "Twin Towers."
June 2005- Viacom's board of directors approves a plan to spin off assets, which
become known as the new Viacom, Inc. That new company is given control of Paramount, while the
core company reforms as CBS Corp.
January 2006- 20th Century Fox sues YouTube to have content from Fox TV shows
such as The Simpsons and 24 removed from YouTube.
June 2006- YouTube and NBC partner to create NBC channel on
YouTube for Internet exclusives, clips, and trailers.
July 2006- Viacom and NBC Universal back journalist Robert Tur in his suit
against YouTube for illegally posting his videos of the 1992 L.A. riots. The legal brief said,
"YouTube incorrectly contends that the DMCA permits it to avoid any responsibility for the
content on its commercial website and completely shift the burden to content owners to discover
and notify it of infringements."
March 2007- Viacom General Counsel Michael Fricklas in a Washington Post op-ed says that YouTube was not just a passive content
host, and that it is fully aware of what it does. "If the public knows what's there, then
YouTube's management surely does. YouTube's own terms of use give it clear rights, notably the
right to take anything down."
May 2007- British Premier League files class action suit against YouTube for
copyright infringement, says Google "knowingly misappropriated and exploited this valuable
property," when it allowed users to post footage from its football games.
June 2007- YouTube introduces Content ID to help content owners identify if
their content is being used, gives them the option to remove unauthorized content, or monetize
it.
August 2007- Google asks Comedy Central personalities Jon Stewart and Stephen
Colbert to testify against Viacom in copyright hearings.
Comedy Central is a Viacom property.
March 2008- Viacom President and CEO Phillippe Dauman says "We've already
achieved a number of things with this lawsuit. It took a long time, but because of our actions,
YouTube has moved in the right direction. They're where they should have been all along."
June 2008- New York District Court rules that Google has to turn over user IDs
and IP addresses to Viacom. Angry users upload nearly 5,000 "Viacom Sucks" videos to
YouTube. Google is later allowed to make this data anonymous.
July 2008- Movie studio Lionsgate partners with YouTube for a branded channel
with ad-supported official content from the studio.
April 2009- Content owners discus "TV Anywhere" plan to tie Web-based video
content into cable subscription fees. Viacom CEO Dauman says, "People are used to paying for
video subscriptions," sees it as a good idea.
June 2009- "TV Everywhere" network scheme launches.
July 2009- Some claims from the Premier League's 2007 suit against YouTube are
dismissed, but claims for "statutory damages for works not registered in the US" are allowed.
September 2009- Google gives individual copyright holders access to the Insight
metrics of YouTube videos that contain their intellectual property according to Content ID.
October 2009- Viacom presents "smoking gun" evidence for its case: internal
e-mails from YouTube staff that show "actual knowledge" that copyright infringement was taking
place on the video sharing site.
November 2009- Google announces YouTube Direct, a
system where media outlets can directly communicate with users and arrange rebroadcasting rights
on a one-to-one basis.
March 2010- Some of Viacom's "smoking gun" documents go public, company claims
"YouTube was intentionally built on infringement."
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