br /What it doesbr /br /Isn’t a chatroom enough for you? Do you need a further degree of interaction and involvement? If that is indeed the case, a visit to this online resource is likely to satisfy your craving. br brIn essence, Seesmic is a video site where people post their own files and you post yours in reply. The website, then, offers an alternative to IM services that could be deemed as more vital, or (in any case) as far more personalized. br brAs you can probably imagine, the main page touches upon items such as “Featured Videos” and “Most Active”, whereas the latest conversation that are underway have their very own space. br brThe opening screen also spotlights conversations one at a time, so that you can see everything as it is happening and developing upon stationing your browser at the site. br brIn final place, make a point of employing the “Feature request” link if you use the site and feel that there is something sorely missing that would give Seesmic and added edge and a better chance of making a stand.br /br /Some questionsbr /br /Is this service completely web-hosted or do you have to install anything?br /br /Why it might be a killerbr /br /Individuals looking for a more personalized way of connecting than IM might find such an approach interesting.br /br /In their own wordsbr /br /“Join the video conversation.”br /br /Link: a href='http://www.seesmic.com'http://www.seesmic.com/abr /Our Review: a href='http://www.killerstartups.com/Video-Music-Photo/seesmic-com-video-conversations-over-the-www'http://www.killerstartups.com/Video-Music-Photo/seesmic-com-video-conversations-over-the-www/abr /br / nbsp;div class="feedflare" a href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=Tjtv9is2"img src="http://feedproxy.google.com/~f/killerstartups/BkQV?d=41" border="0"/img/a a href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=syn6DUNK"img src="http://feedproxy.google.com/~f/killerstartups/BkQV?d=52" border="0"/img/a a href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=5FXEGE6q"img src="http://feedproxy.google.com/~f/killerstartups/BkQV?i=5FXEGE6q" border="0"/img/a a href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=qSFhroAi"img src="http://feedproxy.google.com/~f/killerstartups/BkQV?i=qSFhroAi" border="0"/img/a a href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=5kxjYujJ"img src="http://feedproxy.google.com/~f/killerstartups/BkQV?d=43" border="0"/img/a a href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=pva42Ya7"img src="http://feedproxy.google.com/~f/killerstartups/BkQV?i=pva42Ya7" border="0"/img/a /divimg src="http://feedproxy.google.com/~r/killerstartups/BkQV/~4/deo-dX2Jlj4" height="1" width="1"/

Societe : COMPUTER FUTURES - Lieu de travail : idf/Paris - Type de contrat : CDI - Salaire : Negotiable - Detail : Ce descriptof de poste est dirigé aux professionnels qui souhaitent progresser techniquement dans le domaine financier qui est l'environnement que tout le monde recherche pour la rapidité de l'implémentation des dernières technologies. Mon client, client final, qui vous embauchera en CDI pour vous faire progresser notamment dans la conception de solutions informatiques sur mesure et immédiatement opérationnels. Mon client : - Une maîtrise des techniques à la pointe, entre les mathématiques financières et les technologies du traitement de l'information - Société à taille humaine spécialisée dans la finance de marché - Une équipe de de collaborateurs exigeants et déterminés - Culture de type anglo-saxonne, à la « méritocratie » - Politique salariale très attractive, basée sur le fixe et un variable (en fonction de vos performances individuelles) - Situation dans le centre de Paris - Formations Microsoft, méthodologies... Il recherche aujourd'hui non pas de la main d'oeuvre mais un ou plusieurs collaborateur à forte valeur ajoutée. Vous intégrerez le système Département Système d'Information et Dévelopement qui conçoit et de développe les solutions adaptées à l'activité de leur groupe Au sein de l'équipe de développement tourné d'un côté vers la partie front-office (gestion des risques...) et back-office , vous aurez la responsabilité de la conception et du développement d'applications spécifiques pour les traders de la société. Sous la responsabilité du directeur technique, en interaction avec les experts dotnet et les traders, votre rôle consistera à être véritablement force de proposition au sein de cette équipe, de proposer des solutions pour améliorer la performance de leurs outils. Votre Profil, vos envies: - Vous avez une formation Ecole d'Ingénieurs ou Bac+5 - Vous connaissez les aspects conception, les design patterns - Vous savez vous remettre en cause - Vous apprenez rapidement, appréciez de trouver des solutions techniques Nous vous offrons la chance de rejoindre une société à part, très exigeante, dans laquelle vous deviendrez un professionnel de grande valeur. Appelez Vincent HOGOMMAT au 01.42.99.83.33.

div class='rss_texte'p class=spip+ de 40 personnes inscrites, 30 participants./p p class=spipstrong class=spipLa journée à commencé par une rapide mise en perspective du Forum et de ses enjeux./strong/p p class=spipGus Massiah (CRID)a présenté l'articulation entre le Forum Sciences et démocratie et le FSM, en rappelant la diversité des forums sociaux : mondial, régionaux, nationaux, locaux et thématiques, et l'indépendance de l'initiative pour le forum science et démocratie et l'importance de rechercher les bonnes stratégies pour toucher les mouvements sociaux qui seront à Belém./p p class=spipLionel Larqué (Petits débrouillards et Sciences Citoyennes) souligne les enjeux de l'appropriation des questions de science et de technique par les mouvements sociaux et l'intérêt de leur convergence avec acteurs scientifiques, ONG spécialisées, réseaux et syndicats pour faire levier sur les questions sociétales dont les sciences et les techniques. L'initiative du Forum science et démocratie est un pas dans le sens de l'émergence d'une culture commune de ces univers. Mais ce sera aussi un espace qui nous obligera à aborder des questions qui sont cruciales pour la communauté scientifique, le rôle des sciences, et la responsabilité sociale des scientifiques. Un participant propose de tenir compte des travaux qui ont déjà eu lieu sur ces questions, notamment ceux de a href=http://www.quae.com/livre/?GCOI=27380100417070 class=spip_outP. Roqueplo/a/p p class=spipPar Frédéric Sultan (Vecam) : présentation des résultats du travail de structuration de la discussion à Belém (groupe SOG) articulés autour de l'élargissement de la mobilisation pour les biens communs de la connaissance et de la mobilisation pour la responsabilité sociale des scientifiques et des techniciens./p p class=spipPour Reiner Braun (INES) Le Forum Sciences et démocratie doit permettre de sensibiliser les citoyens et les politiques, à l'idée que la question du développement des sciences et des techniques est, tant que telle, partie intégrante des problématiques du développement de la société. L'importance des sciences et de l'évolution des techniques est sous-estimée par les mouvements sociaux dans l'analyse de leur problématiques propres. Il propose que le Forum Science et démocratie offre la possibilité aux scientifiques et aux techniciens de discuter entre eux de la démocratisation des sciences et des techniques./p p class=spipPour Pascal Janots (FMTS), s'il est évident que les résultats de la recherche peuvent être (et sont) utilisés de manière négative (guerre, crises, ...) il ne faut pas faire porter la responsabilité des situations de crises sur la science en tant que telle et chercher à identifier la bonne et la mauvaise science en fonction des effets de l'usage des découvertes à des fins d'oppression. Cette problématique invite à réfléchir au rôle des experts dans le débat public et à la manière d'aider les scientifiques à travailler avec et dans la société./p p class=spipPour Gus Massiah (CRID), le Forum Sciences et Démocratie doit jouer un rôle pour contrer la montée en puissance de la militarisation de la société et le retour de la pensée fachiste qui tend à instrumentaliser les pratiques scientifiques, notamment dans des disciplines telles que la biologie. Le Forum Science et Démocratie n'a pas vocation à construire une communauté scientifique, mais à mobiliser des scientifiques pour se poser la question de leur responsabilité sociale et développer une pensée critique et contradictoire sur le rôle des sciences dans la société./p p class=spipstrong class=spipLes ateliers :/strong/p h3 class=spipAtelier : Le forum science et démocratie et les ateliers auto-organisés du FSM/h3 p class=spip16 ateliers autogérés sont portés par des organisations présentes dans la rencontre, notamment sur les thèmes suivants :/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Le sens du lien entre science et démocratie/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / richesse et indicateurs de développement/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Biens communs/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Nanotechnologies/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / recherche participative/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / responsabilité sociale des scientifiques/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / les mouvements et mobilisations de chercheurs/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Santé et environnement/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Sciences et techniques/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Nanotechnologies/p p class=spipstrong class=spipPropositions :/strong/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / inviter les porteurs d'activité à ajouter l'indication d'un lien Forum sciences et démocratie dans la présentation de leur activité sur le site du FSM (objectif de visibilité dans le programme)/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / proposer aux porteurs de d'activité d'intégrer le Forum Sciences et démocratie comme partenaire dans l'organisation/p p class=spipCette discussion pose la question des formes de sensibilisation et de mobilisation des porteurs d'activité en rapport avec Science et démocratie dans le FSM et invite à clarifier ce qu'est le Forum Sciences et démocratie qui ne se présente ni comme une entité, ni comme un réseau clairement identifié./p h3 class=spipAtelier : Le Forum sciences et démocratie et la question logistique et communication/h3 p class=spipDifférentes hypothèses de travail pour préparer le Forum sont évoquées : dossier de presse, exploitation du site web, préparation d'actions à distance par chat et téléphone. La question de l'organisation d'une conférence de presse est posée./p p class=spipL'organisation du Forum repose sur la mobilisation de volontaires. Actuellement, une coordination est assurée par Fabien Piasecki et Frédéric Sultan. Il est possible de mobiliser les chargés de communication des réseaux et des organisations engagées dans le Forum sciences et démocratie. Un groupe de communication du FSM à Belém existe sans être pour le moment véritablemet actif./p p class=spip3 médias sont stratégiques pour le Forum Sciences et Democratie :/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Internet/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / les radios locales/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / la presse proche du mouvement altermondialiste. Une proposition d'une tribune dans L'Age de Faire/p p class=spipClaude Henry (Vecam - Vivagora) propose de prendre contact avec TeleSur ? et ViveTele ?./p p class=spipEn aval de la rencontre :/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / l'accent devrait être mis sur l'organisation d'actions locales, notamment en France (proposition des petits débrouillards), qui permettront de s'appuyer sur les résultats de l'initiative à Belém et d'ancrer la démarche dans la durée (processus long)./p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / le site web offre un espace de débat déjà commencé. 50 contributions sont mises en lignes depuis un an. Son exploitation doit être aussi une action prioritaire. Elle doit permettre d'en faire une ressource du débat à poursuivre après le Forum à Belém. Pour cela, il faut le rendre consultable par mots clefs et par fiches de lecture ou résumé d'articles et entretenir la dynamique./p h3 class=spipAtelier : Journée plénières du Forum Sciences et démocratie : 26 et 27 janvier/h3 p class=spipL'atelier a permis de débattre de la forme, de l'articulation et des contenus de la journée proposés par le groupe SOG./p p class=spipstrong class=spipEléments de la discussion :/strong/p p class=spipA/ Est-il pertinent de diviser la rencontre en 2 temps : 1/ d'analyse de la situation du rapport science et démocratie, et 2/ de discussion des propositions alternatives ? notamment pour mettre en évidence les enjeux qui lient sciences et pouvoir dans ses différentes dimensions. Cette orientation ne doit pas faire perdre de vue que la rencontre ne porte pas sur la science, mais sur son rôle et sa place dans la société et les moyens de sa démocratisation./p p class=spipB/ La forme d'organisation des débats en pleniers retenue pour la totalité des 2 journées pose le problème de la dimension participative de la démarche. La discussion a porté sur la pertinence et la possibilité d'organiser des ateliers parallèles à la suite des présentations en plénier pour chaque thème. D'autres formes et temps de participation devraient être mis en chantier : interaction avec des personnes à distance via chat, présentation de posters, de projection vidéo et autre formes d'expression./p p class=spipC/ La place de certaines problématiques semblent sous-estimées dans la programation : 1/ les rapports au savoir profanne (incluant le savoir ancestral mais le dépassant), 2/ la militarisation persistante de l'appareil de production des connaissances et son impact sur la conception de l'activité des chercheurs et la conception de la science en général, 3/ le caractère critique de l'émergence et de la diffusion d'une culture scientifique et technique qui interroge les pratiques et permet d'inscrire la science dans le champs de la démocratie./p p class=spipD/ Comment la structuration de la discussion à Belém permet de prendre en compte les éléments géographiques et culturels qui structurent les différentes visions de la crise de l'appareil de production de la connaissance qui ne se résument pas à un rapport Nord/Sud et scientifique/société civile ?/p p class=spipstrong class=spipPropositions :/strong/p p class=spipstrong class=spip1. L'atelier a proposé des items complémentaires /strongà intégrer dans le découpage de la journée et de poursuivre la discussion à la suite de la retransmission des ateliers./p p class=spipLes items complémentaires proposés :/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / quels défis pour la science ? (du point de vue des scientifiques)/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / quels problèmes posent la science ? (du point de vue des mouvements sociaux)/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Quelle approche du rapport sciences et démocratie depuis le Nord/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Quelle approche du rapport sciences et démocratie depuis le Sud/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Rapport entre sciences et pouvoir./p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / sciences et environnement/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / sciences et militarisation/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / sciences industrie et travail/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / sciences et crises économiques/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / sciences et inégalités/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / la recherche scientifique sans contrainte/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / sciences et éthique/p p class=spipstrong class=spip2. L'atelier a proposé de définir le modus operandi de chaque temps de discussion/strong de la manière suivante :/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / chaque sessions devrait proposer 4 intervenants./p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Chaque intervenant disposera de 1/4 d'heure de temps de parole./p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / La seconde heure de discussion se déroulera sous forme d'ateliers parallèles ou de débat avec la salle./p p class=spipLa dicussion de l'atelier Journée plénières du Forum Sciences et démocratie : 26 et 27 janvier s'est poursuivie à l'issue de la présentation des rapports des ateliers. La discussion à porté sur :/p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / la modification de la structure de la journée du 26 et du 27 matin, format, contenus et modus operandi./p p class=spipimg src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / l'introduction d'un temps de travail sur le processus science et démocratie, ouvert à tous et permettant de préparer la table ronde finale du 27/01./p p class=spipstrong class=spip3. L'atelier a proposé des modifications des journées 26 et 27 janvier/strong au groupe SOG :/p table class=spip summary= captionstrong class=spipPropositions de modifications/strong/caption tbody /tbody /table table class=spip tbody tr class=row_eventdMonday 26th/td/tr /tbody /table table class=spip tbody tr class=row_eventdA/ Introductive plenary Session : Science and democracy : what are the problems ?br / br /i class=spipthat could be a fusion ofbr / /ibr / br /Science, technology and democracy IN THE CONTEXT OF CRISISbr / br /+br / br /Production of knowledge/tdtdTime : 1:30br / br /3 speakers + débate or workshopsbr / br /Items :br / br /img src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / what chalenges for science ?br / br /img src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / what problems from science ?br / br /img src=http://www.a-brest.net/local/cache-vignettes/L8xH11/puce-1cfde.gif width='8' height='11' alt=- style='height:11px;width:8px;' class='' / Science and power/td/tr /tbody /table table class=spip tbody tr class=row_eventdB/ Knowledge : from privatization to commons goodsbr / br /i class=spipIn place of /ibr / br /Access to knowledge : building the commons/tdtdTime : 2:30br / br /4 speakers + débate or workshops/td/tr /tbody /table table class=spip tbody tr class=row_eventdC/ The new struggle in the scientific and technical fieldsbr / br /i class=spipIn place of /ibr / br /Knowledge-based SOCIETY and new forms of struggles /tdtdTime : 2:00br / br /4 speakers + débate or workshops/td/tr /tbody /table table class=spip tbody tr class=row_eventdD/ Science and democracy in a sustainable worldbr / br /i class=spipIn place of/ibr / br /a finite world : necessity to preserve ressources and share wealth/tdtdTime : 2:00br / br /4 speakers + débate or workshops/td/tr /tbody /table table class=spip tbody tr class=row_eventdE/ science and democracy processus/tdtdTime : 2:00 - (from 17:00 to 19:00)br / br /Open space discussing the processus and preparing the round-table of the end of the session (27th of january)./td/tr /tbody /table table class=spip tbody tr class=row_eventdJanuary 27th/td/tr /tbody /table table class=spip tbody tr class=row_eventdF/ Democratic practices of science and technique and social responsability for scientists and citizensbr / br /i class=spipIn place of /ibr / br /Scientists, democracy and social responsibility/tdtdTime : 2:30br / br /4 speakers + débate or workshops/td/tr /tbody /table table class=spip tbody tr class=row_eventdG/ Round tablebr / br /i class=spipIn place of/ibr / br /First Step/tdtdTime 1:30/tdtd/td/tr /tbody /table/div div class='rss_ps'L'adresse originale de cet article est a href=http://fsm-sciences.org/spip.php?article304 class=spip_outhttp://fsm-sciences.org/spip.php ?article304/a/div

Publication Date: 2008 Nov 14 PMID: 19041879br/Authors: Jehle, S. - van Rossum, B. - Stout, J. R. - Noguchi, S. R. - Falber, K. - Rehbein, K. - Oschkinat, H. - Klevit, R. E. - Rajagopal, P.br/Journal: J Mol Biolbr/br/Atomic-level structural information on alphaB-crystallin (alphaB), a prominent member of the small heat shock protein family, has been a challenge to obtain due its polydisperse oligomeric nature. We show that magic-angle spinning solid-state NMR can be used to obtain high-resolution information on an approximately 580-kDa human alphaB assembled from 175-residue 20-kDa subunits. An approximately 100-residue alpha-crystallin domain is common to all small heat shock proteins, and solution-state NMR was performed on two different alpha-crystallin domain constructs isolated from alphaB. In vitro, the chaperone-like activities of full-length alphaB and the isolated alpha-crystallin domain are identical. Chemical shifts of the backbone and C(beta) resonances have been obtained for residues 64-162 (alpha-crystallin domain plus part of the C-terminus) in alphaB and the isolated alpha-crystallin domain by solid-state and solution-state NMR, respectively. Both sets of data strongly predict six beta-strands in the alpha-crystallin domain. A majority of residues in the alpha-crystallin domain have similar chemical shifts in both solid state and solution state, indicating similar structures for the domain in its isolated and oligomeric forms. Sites of intersubunit interaction are identified from chemical shift differences that cluster to specific regions of the alpha-crystallin domain. Multiple signals are observed for the resonances of M68 in the oligomer, identifying the region containing this residue as existing in heterogeneous environments within alphaB. Evidence for a novel dimerization motif in the human alpha-crystallin domain is obtained by a comparison of (i) solid-state and solution-state chemical shift data and (ii) (1)H-(15)N heteronuclear single quantum coherence spectra as a function of pH. The isolated alpha-crystallin domain undergoes a dimer-monomer transition over the pH range 7.5-6.8. This steep pH-dependent switch may be important for alphaB to function optimally (e.g., to preserve the filament integrity of cardiac muscle proteins such as actin and desmin during cardiac ischemia, which is accompanied by acidosis).br/br/post to: a href = http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19041879title=Entrez+PubmedCiteULike/a

Metro Rules of Conduct is a game about public transportation, but not in the way you would normally expect it to be. Based on Kian's experiences of commuting in Stockholm, the game involves finding something to stare at during the idle time you will have waiting to arrive at your intended stop. Train seats are placed in such a manner that passengers would be facing each other to encourage social interaction, but it is the exact opposite that most people would do by avoiding eye contact whenever possible, and the developer has sought to simulate this feeling of discomfort by creating a game around it.
Use the cursor keys to look around, and stare discreetly at the accessories or pieces of clothing worn by the other passengers for points. Time is limited, so you will have to score as much as you can before reaching the final destination of your trip.
According to the author, an easter egg has been added to this updated release. (source: Rock Paper Shotgun)
Name: Metro Rules of Conduct
Developer: Kian Bashiri
Type: Arcade
Type: Browser


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Author: a072548 Keywords: health Added: December 2, 2008

Publication Date: 2008 Nov 30 PMID: 19043403br/Authors: Elde, N. C. - Child, S. J. - Geballe, A. P. - Malik, H. S.br/Journal: Naturebr/br/Distinguishing self from non-self is a fundamental biological challenge. Many pathogens exploit the challenge of self discrimination by employing mimicry to subvert key cellular processes including the cell cycle, apoptosis and cytoskeletal dynamics. Other mimics interfere with immunity. Poxviruses encode K3L, a mimic of eIF2alpha, which is the substrate of protein kinase R (PKR), an important component of innate immunity in vertebrates. The PKR-K3L interaction exemplifies the conundrum imposed by viral mimicry. To be effective, PKR must recognize a conserved substrate (eIF2alpha) while avoiding rapidly evolving substrate mimics such as K3L. Using the PKR-K3L system and a combination of phylogenetic and functional analyses, we uncover evolutionary strategies by which host proteins can overcome mimicry. We find that PKR has evolved under intense episodes of positive selection in primates. The ability of PKR to evade viral mimics is partly due to positive selection at sites most intimately involved in eIF2alpha recognition. We also find that adaptive changes on multiple surfaces of PKR produce combinations of substitutions that increase the odds of defeating mimicry. Thus, although it can seem that pathogens gain insurmountable advantages by mimicking cellular components, host factors such as PKR can compete in molecular 'arms races' with mimics because of evolutionary flexibility at protein interaction interfaces challenged by mimicry.br/br/post to: a href = http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19043403title=Entrez+PubmedCiteULike/a

divimg alt="" src="http://hits.guardian.co.uk/b/ss/guardiangu-feeds/1/H.15.1/60279?ns=guardianpageName=Art+and+design%3A+Architect+slams+%27dismal%27+UK+designch=Art+and+designc3=The+Guardianc4=Architecture%2CArt+and+design%2CCulture+section%2CUK+news%2CCommunities+%28Society%29%2CSocietyc5=Society+Weekly%2CArt%2CNot+commercially+useful%2CCommunities+Society%2CArchitecturec6=Robert+Boothc7=2008_12_03c8=1127808c9=articlec10=GUc11=Art+and+designc12=Architecturec13=c14=h2=GU%2FArt+and+design%2FArchitecture" width="1" height="1" //divpOne of Prince Charles's allies in his battle against modern architecture has attacked the "disappointing to dismal" design of British postwar towns./ppSparking anger among architects, Andres Duany flew in from America and yesterday unveiled a 64-point litany of mistakes made by British architects and planners over the last 50 years. /ppHe accused architects of being "infantile" in pursuing ego-driven visions and said they were "heedless of technical and social dysfunction and widespread lack of popularity" caused by their designs./ppDuany is one of the original designers of Poundbury, the prince's new town in Dorset, and said the leading lights of modernist architecture including Richard Rogers, Frank Gehry, Zaha Hadid and Peter Eisenman were "increasingly irrelevant"./ppHe called on architects and planners to step aside and allow a new generation of amateurs to lead development in the 21st century. /ppThe broadside was met by a vociferous response from leading modern architects who have become used to regular disputes with the prince and his allies. Sunand Prasad, president of the Royal Institute of British Architects, said Duany was "living in another world"./ppHe conceded that architects' craft skills and traditional knowledge had been swept aside too easily between the 1950s and 1970s, but said architects were now building the "highest performance" buildings ever./ppDuany's outburst, will reignite a battle between architects who believe in modernism and his own "church" of new urbanism, which argues that towns should be built to strict codes, often based on traditional design./ppDuany used new urbanism to design Seaside, the Florida community which provided the backdrop to the film The Truman Show, and Charles has embraced the principles of new urbanism on projects to design new settlements from Newquay, Cornwall to Llandarcy, near Neath. /ppHis intervention was timed to coincide with the unveiling of a masterplan for Hertfordshire, his most ambitious UK scheme yet. In it he advocates a new town and a series of garden villages built on open land in which residents would be obliged to grow fruit and vegetables for market./pp"It is inexplicable why architects and planners continue to pursue radical innovation as if it were 1945 every morning," he said./pp"Only architecture, confusing itself with fashion as a platform for cultural expression, continues to be avant garde, heedless of its cost overruns, social and technical dysfunction and widespread lack of popularity."/ppHe cited "gratuitous shapes" in buildings such as winged roofs which quickly go out of fashion, "amazingly rude" colours on shop signs which "are just a vulgar way to attract attention" and civic buildings that "look common" when they should be grand./ppOut-of-town retail parks, excessive road signage and "placeless architecture that could be anywhere in the world" were also criticised. Duany advocates a return to "matter of fact architecture" as exemplified by the traditional English village. /ppPrasad said it was "obviously untrue" that the majority of architects want to express themselves regardless of context. "It is not so much the innovation and the ego that is causing the problem," he said. /pp"It is the commercial pressure to build large on sites which can't take it; it is the haphazard development of towns and the widespread confusion over our democratic planning process."/ppPrasad said many of Duany's complaints seemed to stem from the decision to build a car-based society, and the way highways engineers took control of urban design./pp"It was wrong to aim for a society dominated by cars," he said. /pp"But most architects and planners have moved on, so he is really railing against a problem that doesn't exist anymore."/ph2What not to do/h2p· Avoid fashionable architecture - buildings that are obsessively of our time will be out of date too soon/pp· Civic buildings should be grand and private buildings should recede into the background/pp· Avoid overly transparent facades - mess inside a building looks like an unkempt yard/pp· Avoid many buildings by one designer - diversity is the hallmark of a great place/pp· Avoid meandering streets - excessive curves confuse and aggravate/pp· Avoid gated-off estates - they undermine social interaction/pp· Avoid businesses in the suburbs - every job means one less person to enliven a town centre/pdiv style="float: left; margin-right: 10px; margin-bottom: 10px;"ullia href="http://www.guardian.co.uk/artanddesign/architecture"Architecture/a/lilia href="http://www.guardian.co.uk/society/communities"Communities/a/li/ul/diva href="http://www.guardian.co.uk"guardian.co.uk/a copy; Guardian News Media Limited 2008 | Use of this content is subject to our a href="http://users.guardian.co.uk/help/article/0,,933909,00.html"Terms Conditions/a | a href="http://www.guardian.co.uk/webfeeds/1,,1309488,00.html"More Feeds/a pa href="http://feedads.googleadservices.com/~at/ebN1kc003nMCZPSXanM9fynNtzw/a"img src="http://feedads.googleadservices.com/~at/ebN1kc003nMCZPSXanM9fynNtzw/i" border="0" ismap="true"/img/a/p

centerimg id="image1673" src="http://rhizome.org/imagebase/article/2147/ozzfinal.gif" alt="ozzfinal.gif" //centerbr / pSet up by artist Natalie Jerimijenko, the ia href="http://www.nyu.edu/projects/xdesign/ooz/"Ooz/a/iproject is a non-traditional rest area for animals that stands in contrast to the nearby Bronx Zoo. Notably free of cages, iOoz/i is a place where, according to the artist, animals remain "by choice" and is designed to encourage new kinds of human/animal interaction. On Thursday evening, Jerimijenko will tackle a different but related topic: how urban dwellers can engage with a whole new set of species she claims will soon be living in close proximity. Jeremijenko lists coyote, luna moths, rhinoceros, beetles, raccoons and wild turkey as among the new arrivals that will force humans to rethink biodiversity and the kind of environmental services that are needed. The workshop will take place at the a href="http://www.vanalen.org"Van Alen Institute/a in New York City and the organizers request that attendees RSVP to torvsp[AT]vanalen.org by the end of today. /p p class="more"a href="http://www.vanalen.org"Link raquo;/a/pimg src="http://feeds.feedburner.com/~r/rhizome-fp/~4/472822002" height="1" width="1"/

Modern newsrooms have to engage in a never-ending conversation with their community. This may sound self-evident, but it can be a tough sell in a newsroom working under high pressure. So how do you get reporters to buy into the proposition that they need to listen to their audience? They need to see for themselves the enthusiasm that the community has for talking back to its reporters.

The people formerly known as the readers have now become readers/writers. In the "good old days" of the print newspaper, we only got a few letters each day. Today, we get hundreds and sometimes thousands of comments on our news articles each day. With the click of a button, readers can easily and instantly post reactions to articles. Furthermore, the readers don't only react to our articles -- they react far more often to each others' comments. The article may start a discussion, but it does not necessarily remain the center of attention.

This interaction gives us more than additional eyeballs; it teaches us new aspects of storytelling. For instance, a news website is sometimes more about telling a story in a way to bring the community together rather than about providing "hard news."

Three recent stories published in Belgian business newspaper De Tijd provide good examples of how a newspaper can adapt to its new role as a community center.

The Story of a New American President

The election day in the U.S. was an election night for the people in Belgium. Of course, our newspaper covered the elections intensely, but we were at a loss for what to do during the night. People who were so interested in the election that they would stay up all night would surely watch for the results on CBS or CNN, so what would be the point of De Tijid scrambling to post breaking coverage on its site? Would it not be better to focus on "the day after" and deliver more value by writing detailed analysis about the results?

We thought it over and realized there was something valuable in covering the election as it happened, but it was something beyond scoops and analysis: We could gather the community and facilitate a conversation. Compare it with a soccer game: One can watch it at home, alone, or experience the magic of being all together with fellow fans in the stadium.

That night, we launched our CoverItLive live-blog application and I commented on the election night with our colleague in New York City. Several other colleagues also made guest appearances that night. Most striking of all, several thousand community members also visited our live-blog/chatroom that night to post comments -- even as they were, indeed, watching the election results on CNN and CBS.

Even though they were technically getting their news from another source, that did not matter. They wanted more than to just hear the news; they wanted to discuss what had happened, share in the joy (of many) and the disappointment (of a few), and hear what other ordinary people had to say about it. We found that as live-blog hosts we didn't have to comment all the time, as chatty community members filled the "dead air." Besides, as soon as you get hundreds or thousands of participants, moderating what others say is sometimes enough to keep you busy.

A Judge Decides

Like so many nations, Belgium has been suffering the consequences of the global financial crisis. The biggest bank of the country, Fortis, had to be urgently sold to the French bank BNP Paribas. Fortis shareholders went into shock as the value of their stocks plummeted and they immediately began to question the government's response in organizing the transaction.

Inevitably, people went to court.

On the week in question, a judge would deliver a very important ruling on the Fortis sale. The event was structured simply enough: The judge would begin by explaining his reasoning, often meandering in one direction and then another, before finally announcing his final decision. In this type of proceeding, it is impossible to know whether the judge's monologue will go on for one hour or four.

We had doubts about whether or not to live-blog the event. Why not just wait for the news of the verdict -- the only hard, fundamental fact that mattered -- instead of having live coverage of the long speech?

Once again, we reasoned that there was a community out there -- tens of thousands of people in the financial sector and, of course, many Fortis shareholders and clients. There are a lot of emotions involved in this case; it is the biggest issue in our De Tijd community. We just felt we had to be there, with our community, being their ears and eyes (other events taught us that even streaming video of an event does not change this).

So some colleagues did the live-blogging (Dutch language), while others moderated the community dialogue (community members could react in real time in the chatbox). There was a lot of moderating to do in this conversation -- more than 10,000 people attended the session! And they had hundreds or thousands of thoughts and questions to share.

At least as impressive were the reactions after the event. We got numerous responses by chat and email, thanking us by chat or email for the live coverage. It was evident this was not only about reporting the verdict. Although the news value of the judge's speech may not have been particularly high, it was evident that this was what the public needed to hear. And, even more, they needed it as an opportunity to be heard.

Who Was First?

On one recent weekend, another newspaper ran a story about a huge bridge loan authorized by the Belgian state for Fortis. The newspaper said the loan had been authorized very discreetly. Our website did not run that story, because the very discreet loan was, in fact, not very discreet at all: De Tijd had broken that same story three weeks earlier.

We decided not to run the "new" story for reasons that should be familiar by now: There was no new hard news. In fact, we considered this a non-event. However, our community was shocked. They heard about the news in the other newspaper and yet saw no mention of it on our site, which is often thought of as the leading source of information on the Fortis case.

People started posting the article in the comments section of the site, complaining that De Tijd was "giving up" the Fortis coverage. Some suggested the journalists "gave up" after pressure from high places.

Suddenly, our newspaper found out that it had limited control about what was published on the site: Even if the editorial staff did not run a story, people would do it themselves by posting it in the comments and, more so, add their own conclusions. Suddenly a non-event had become a news story after all.

The editor in chief reacted (Dutch language) immediately. He told our community that his journalists had no intention of abandoning coverage -- quite the contrary. He explained that the story about the bridge loan was actually an old story, and linked to the story we had published three weeks earlier.

The Monday after we learned that his reaction was by far the most read story of the weekend. There was a lot of "real hard news" on the site, but for our community the discussion about the Fortis coverage was far more important, even though nothing new had happened there.

Unanswered Questions

After these incidents, many colleagues now seem to accept that engaging in conversations with the community is an important part of our role as a newspaper. The community appreciates it enormously, and it is also the sensible thing to do in terms of encouraging visitors to spend more time on the website.

Of course, this current financial crisis limits the amount of time that reporters can spend fostering a sense of community as those working in the newsroom have other jobs to do. So how can we still make sure that we don't ignore community development during these troubled times? Some possibilities we are working on include:

> Considering inviting community members to be moderators or else outsource moderation duties.

> Explaining the rules and guidelines for comments clearly and in a positive way.

> Using well-known symbols to make moderation clearer: We give serious offenders a "yellow card," which means their reactions are no longer published in real time but need prior approval. In extreme cases we give a "red card," banning them. We do not use these cards for someone who only went off-topic, but for people insulting other participants, for instance, or using repeatedly unacceptable language.

> Buying or developing a system wherein community members can rate comments and filter out those with low marks.

Whatever system we go for, it remains crucial that journalists running a story know how the community responds. Reporters should realize that while not every reader of a business newspaper is a CEO or a PhD in Economics, they can still learn a lot from their community just by engaging them in online conversations.

Roland Legrand is in charge of Internet and new media at Mediafin, the publisher of leading Belgian business newspapers De Tijd and L'Echo. He studied applied economics and philosophy. After a brief teaching experience, he became a financial journalist working for the Belgian wire service Belga and subsequently for Mediafin. He works in Brussels, and lives in Antwerp with his wife Liesbeth.

Illustration of social media by Omar Lee for MediaShift.

This is a summary. Visit our site for the full post ».

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