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Out of the jaws of death: PRMT5 steers p53

Nature Cell Biology 10, 1389 (2008). doi:10.1038/ncb1208-1389

Author: Shelley L. Berger

The tumour suppressor p53 triggers either cell-cycle arrest or apoptosis. Now, arginine methylation joins a panoply of other post-translational modifications that regulate p53. PRMT5 mediates p53 methylation, which disposes the cell to arrest rather than death.