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MacUpdate - Mac OS X -
1 days and 7 hours ago
TV Show Tracker 1.1.1 TV Show Tracker lets you track all of your favorite TV Shows really
easily in a user-friendly interface. Get information about the latest episode aired and the next
episode scheduled.
Designed for a great user experience:
- Find all your favorite TV Shows through TheTVDB.comÂ’s huge database.
- Search for your favorite TV Shows by name in your native language*. The user interface is
fully translated.
- Choose how many TV Shows you want to be shown then scroll through the others.
- Keep an eye on your favorite TV Shows offline. Data is stored on your computer and updated as
soon as you go online.
- Supported languages: English, French, German, Portuguese, Spanish, Swedish.
WHAT'S NEWVersion 1.1.1:
- TV Shows now sorted by next air date
- Italian localization added
REQUIREMENTSMac OS X 10.5 or later.
DEVELOPER Pixel
Perfect Widgets
DOWNLOADS1532
DOWNLOAD NOW
(183 K)
More information
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iPod touch Fans forum -
1 days and 11 hours ago
Hi Everyone!
I just wanted to let you know about our new version of Imangi. This is a huge international update
for us, and we are now one of the few word games on the App Store with full support for most major
languages. Players from around the world can now enjoy our addictive word puzzle in their native
language, or they can play in any of the other supported languages to brush up on their skills.
Here is a full list of what is included in this release:
- Fully localized in English, Spanish, French, Italian, German
- Russian localization coming soon
- Word lists for English, Spanish, French, Italian, German, and Russian
- Improved word lists for all languages
- Daily Challenges for each language
- New icon
The updated version of Imangi is available immediately on the App Store for $2.99. If you already
own Imangi, the update is free.
Here are a few screenshots of the game in different languages. Enjoy!
-Keith
German / Russian:
Spanish / Italian:

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Mac Forums - iPod touch -
1 days and 11 hours ago
Hi Everyone!
I just wanted to let you know about our new version of Imangi. This is a huge international update
for us, and we are now one of the few word games on the App Store with full support for most major
languages. Players from around the world can now enjoy our addictive word puzzle in their native
language, or they can play in any of the other supported languages to brush up on their skills.
Here is a full list of what is included in this release:
- Fully localized in English, Spanish, French, Italian, German
- Russian localization coming soon
- Word lists for English, Spanish, French, Italian, German, and Russian
- Improved word lists for all languages
- Daily Challenges for each language
- New icon
The updated version of Imangi is available immediately on the App Store for $2.99. If you already
own Imangi, the update is free.
Here are a few screenshots of the game in different languages. Enjoy!
-Keith
German / Russian:
Spanish / Italian:

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Bioinformatics - current issue -
1 days and 13 hours ago
Peptide-based proteomics supports identification and quantification as well as localization of
post-translational modifications (PTMs) within proteins extracted from biological samples. The
‘bottom-up’ approach involves the digestion of proteins into peptide fragments that
can be detected and sequenced with liquid chromatography coupled with tandem mass spectrometry
(LC-MS/MS). A web-based application, iPEP, was developed to compare the effectiveness of
different proteolytic digests in detecting specific sequences. Furthermore, peptide populations
can be examined to help optimize detection of certain groups of proteins relative to the proteome
and the digested peptidome. The application reports proteolytic peptide sequences, theoretical
molecular weights and functional annotations using Gene Ontology (GO) terms. The iPEP tool can
assist with experimental design by maximizing the detection of proteins, consensus sites and
modified residues of interest for individual proteins or as part of large-scale proteomic assays.
Availability: http://ipep.moffitt.org
Contact: steven.eschrich@moffitt.org; john.koomen@moffitt.org

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MacUpdate - Mac OS X -
1 days and 22 hours ago
iShowU HD Pro 2.0.5b iShowU HD Pro... The pinnacle of realtime capture. Faster than ever
with more features to boot! Create tutorials, make a demo for the web, record your favorite game
(World of Warcraft!), collaborate on UI design, show tech support what's really going on with that
broken program.
WHAT'S NEWVersion 2.0.5beta:
Upgrade note If you run this version you won't be able to use a previous version
of iShowU HD without first making some changes. Please see this post for details.
-
Recording Recovery - Normally if you have a crash or other terminal event
during recording your work is lost (and that's BAD). shinywhitebox humbly preset: recovery.
Restart iShowU HD and it'll now recover as much of your movie as is possible.
-
Low CPU mode is now more efficient - up to 35% depending on the size of your
recordings (larger recordings see a greater efficiency boost). This means up to 35% less CPU
and around the same reduction in disk bandwidth per second.
-
New Low CPU modes - Now you can replicate iShowU Classic functionality and
have variable length durations for your video frames (this'll break Final Cut compatibility -
but at least you get the choice now). This option is available in pro mode only.
Fixes
- Pause now ... pauses.
- Upload scripts are now upgraded if necessary.
- Fixed issues with HD (non Pro mode) when recording. Recording rate (fps) is now smoothly
limited to what the compressor can achieve in realtime (since HD doesn't have a Low CPU mode).
This results in movies that are considerably smoother than they were in previous versions (e.g:
recording Google Earth).
- All preset tooltips now have correct tooltips.
- Now presents a warning dialog if an attempt to upgrade a persistent store fails.
Changes
- Countdown timer can now be moved during the countdown (and doesn't overlay the entire
screen any more).
- More presets for Final Cut (Apple Intermediate versions of the ProRes presets).
- Various registration system updates.
- Default preview rate set to 12 fps (reduces preview load while idle).
- Fixes and enhancements to the audio recorder.
- Updated instructions on the Capture area display (Return - confirm capture area).
- Update the manual with information about recovery mode, and the new Low CPU mode options
(Off, Auto, On).
- Added Brazilian Portuguese localization.
- Added French translation.
-
Translators - updated xibs
- RegistrationController.xib
- CaptureSettings.xib.
- MainUI.xib
REQUIREMENTSMac OS X 10.5 or later.
DEVELOPER shinywhitebox
DOWNLOADS2820
DOWNLOAD NOW
(14.9 MB)
More information

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BMC Neuroscience -
2 days and 7 hours ago
Publication Date: 2008 Nov 13 PMID: 19014551br/Authors: Sarmiere, P. D. - Weigle, C. M. - Tamkun,
M. M.br/Journal: BMC Neuroscibr/br/ABSTRACT: BACKGROUND: The Kv2.1 delayed-rectifier K+ channel
regulates membrane excitability in hippocampal neurons where it targets to dynamic cell surface
clusters on the soma and proximal dendrites. In the past, Kv2.1 has been assumed to be absent from
the axon initial segment. RESULTS: Transfected and endogenous Kv2.1 is now demonstrated to
preferentially accumulate within the axon initial segment (AIS) over other neurite processes; 87%
of 14 DIV hippocampal neurons show endogenous channel concentrated at the AIS relative to the soma
and proximal dendrites. In contrast to the localization observed in pyramidal cells, GAD positive
inhibitory neurons within the hippocampal cultures did not show AIS targeting.
Photoactivable-GFP-Kv2.1-containing clusters at the AIS were stable, moving 1 m/hr with no channel
turnover. Photobleach studies indicated individual channels within the cluster perimeter were
highly mobile (FRAP = 10.4 +/- 4.8 sec), supporting our model that Kv2.1 clusters are formed by the
retention of mobile channels behind a diffusion-limiting perimeter. Demonstrating that the AIS
targeting is not a tissue culture artifact, Kv2.1 was found in axon initial segments within both
the adult rat hippocampal CA1, CA2, and CA3 layers and cortex. CONCLUSIONS: In summary, Kv2.1 is
associated with the axon initial segment both in vitro and in vivo where it may modulate action
potential frequency and back propagation. Since transfected Kv2.1 initially localizes to the AIS
before appearing on the soma, it is likely multiple mechanisms regulate Kv2.1 trafficking to the
cell surface.br/br/post to: a href =
http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19014551title=Entrez+PubmedCiteULike/a

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