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Journal of Neuroscience -
14 hours and 37 minutes ago
Publication Date: 2008 Nov 19 PMID: 19020044br/Authors: Hendrickson, R. C. - Krauthamer, S. -
Essenberg, J. M. - Holy, T. E.br/Journal: J Neuroscibr/br/Laterally connected inhibitory circuitry
is found throughout the nervous system, including many early sensory processing systems. The extent
to which it plays a role in shaping neuronal stimulus selectivity in systems like olfaction,
however, which lack a simple two-dimensional representation of their stimulus space, has remained
controversial. We examined this issue using an experimental preparation that allowed
electrophysiological recording from the accessory olfactory bulb of an anesthetized mouse during
the controlled delivery of pheromonal stimuli, in this case derived from the urine of male and
female mice. We found that individual neurons were often highly selective for the sex of the urine
donor. Examination of both explicitly inhibitory responses, as well as responses to mixtures of
male and female urine, revealed that laterally connected inhibition was both prevalent and of large
magnitude, particularly for male-selective neurons. Pharmacological manipulation of this inhibition
resulted in a shift in many neurons' stimulus selectivities. Finally, we found that a behavioral
response (pregnancy block) evoked by the presence of unfamiliar male urine could be suppressed by
the addition of female urine to the stimulus, demonstrating that this system displays a behavioral
opponency consistent with neural inhibition. Together, these results indicate that laterally
connected inhibitory circuitry in the accessory olfactory bulb plays an important role in shaping
neural selectivity for natural stimuli.br/br/post to: a href =
http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19020044title=Entrez+PubmedCiteULike/a

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Ubergizmo -
20 hours and 43 minutes ago
centerimg title="NVIDIA enters the top supercomputers list at #29" style="MARGIN: 0px" alt="NVIDIA
enters the top supercomputers list at #29"
src="http://www.ubergizmo.com/photos/2008/11/nvidia-tesla.jpg" border="0" //centerbr / pThe Tokyo
institute of Technology has built a supercomputer called TSUBAME that uses NVIDIA's Tesla GPU. It
is fast enough to enter the coveted list of top 500 most powerful computers in the world (as
measured by the a href="http://en.wikipedia.org/wiki/LINPACK" target="_blank"Linpack/a benchmark).
The reason for switching to GPU computing is clear: /p blockquoteldquo;In testing our key
applications, the Tesla GPUs delivered speed-ups that we had never seen before, sometimes even
orders of magnitude ndash; a tremendous competitive boost for our scientists and engineers in
reducing their time to solution.rdquo; (Satoshi Matsuoka, Tokyo Tech)/blockquote pIt's unclear what
is the ratio between space, power consumption and performance, but something tells me that we will
see more of these./p pPermalink: a
href="http://www.ubergizmo.com/15/archives/2008/11/nvidia_enters_the_top_supercomputers_list_at_29.html"NVIDIA
enters the top supercomputers list at #29/a from a href="http://www.ubergizmo.com"Ubergizmo/a | a
href="http://www.uberbargain.com/"Good deals/a | Hot: a
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freshmeat.net announcements (Unix) -
21 hours and 30 minutes ago
img src="http://c.fsdn.com/fm/screenshots/36796_thumb.png" align="right" alt="Screenshot"
hspace="10" vspace="10" NoMachine NX is a fast terminal server and desktop virtualization system
based on the X11 protocol. NX is an order of magnitude faster than VNC or X11 and can run on
bandwidth as narrow as 10 kBit/sec. In addition, NX translates and embeds the MS Windows Terminal
Server and VNC protocols into X/NX, enabling users to compress and accelerate remote Windows and
VNC sessions. The NX project provides a suite of libraries and X11 proxying agents implementing
efficient compression and optimized transport of X11, SMB, IPP, HTTP, and arbitrary protocols like
audio and video over the Internet. hr / strongLicense:/strong GNU General Public License (GPL) hr /
strongChanges:/strongbr / The new server, which collects all the fixes sported by the 3.2.0
maintenance releases, adds solutions for problems such as: upgrading of NX Server causes
replacement of the DSA custom key, and NX Server may choose a wrong display number when looking for
a free display. pa href="http://feedads.googleadservices.com/~a/5_bFzTrJrddYUWNfjuUk1-wtVVA/a"img
src="http://feedads.googleadservices.com/~a/5_bFzTrJrddYUWNfjuUk1-wtVVA/i" border="0"
ismap="true"/img/a/pimg
src="http://feedproxy.google.com/~r/freshmeat/feeds/fm-releases-unix/~4/1uAAXR1N6kE" height="1"
width="1"/

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freshmeat.net announcements (Global) -
21 hours and 30 minutes ago
img src="http://c.fsdn.com/fm/screenshots/36796_thumb.png" align="right" alt="Screenshot"
hspace="10" vspace="10" NoMachine NX is a fast terminal server and desktop virtualization system
based on the X11 protocol. NX is an order of magnitude faster than VNC or X11 and can run on
bandwidth as narrow as 10 kBit/sec. In addition, NX translates and embeds the MS Windows Terminal
Server and VNC protocols into X/NX, enabling users to compress and accelerate remote Windows and
VNC sessions. The NX project provides a suite of libraries and X11 proxying agents implementing
efficient compression and optimized transport of X11, SMB, IPP, HTTP, and arbitrary protocols like
audio and video over the Internet. hr / strongLicense:/strong GNU General Public License (GPL) hr /
strongChanges:/strongbr / The new server, which collects all the fixes sported by the 3.2.0
maintenance releases, adds solutions for problems such as: upgrading of NX Server causes
replacement of the DSA custom key, and NX Server may choose a wrong display number when looking for
a free display. pa href="http://feedads.googleadservices.com/~a/bo2A-P226ZXZ_fEYkja2sNVBZVo/a"img
src="http://feedads.googleadservices.com/~a/bo2A-P226ZXZ_fEYkja2sNVBZVo/i" border="0"
ismap="true"/img/a/pimg
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width="1"/

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Guardian Unlimited -
1 days ago
divimg alt=""
src="http://hits.guardian.co.uk/b/ss/guardiangu-feeds/1/H.15.1/95329?ns=guardianpageName=World+news%3A+Majority+of+China+earthquake+victims+still+unidentifiedch=World+newsc3=guardian.co.ukc4=China+earthquake+2008%2CChina+%28News%29%2CNatural+disasters+and+extreme+weather+%28News%29%2CWorld+newsc5=Not+commercially+useful%2CCharitiesc6=Tania+Braniganc7=2008_11_21c8=1121958c9=articlec10=GUc11=World+newsc12=China+earthquakec13=c14=h2=GU%2FWorld+news%2FChina+earthquake"
width="1" height="1" //divpSix months after the a
href="http://www.guardian.co.uk/world/chinaearthquake"Sichuan earthquake/a, only around a quarter
of the 70,000 victims have been identified, a Chinese official said today./ppThe details emerged as
leaders of the south-western province warned that survivors faced a grim winter, with some living
in tents with little insulation and struggling to find sufficient food and warm clothing. The
7.9-magnitude shock left almost 4 million people homeless./ppTemperatures can fall to well below
freezing in the mountains and Wei Hong, the executive vice-governor of Sichuan, said experts
predicted they would be up to one degree Celsius colder than usual this year./pp"Some senior
citizens and children are in need of basic equipment to keep them warm," he said. "People in some
quake-stricken areas even face the tough problem of provisions for this winter and the coming
spring."/ppWei said that a staggering amount of work was still needed, and that the region would
need 3 trillion yuan by 2010./ppBy the middle of this month, almost 200,000 homes had been rebuilt
and 685,000 homes were under reconstruction. But another 1.94m households still needed to be
rebuilt or repaired and sites were still being selected for 25 townships which needed to be
relocated./ppAsked how many students had died in schools that collapsed in the quake, Wei said
19,065./ppHowever, Li Jiang, from the Sichuan provincial propaganda office, later said that figure
referred to the total number of bodies identified, blaming mistranslation by an official
interpreter./ppThe deaths of thousands of children in collapsed schools became a highly sensitive
issue for the authorities after outrage spread through China about shoddy building standards.
/ppReports have been banished from the media and parents who sought investigations or tried to sue
local authorities have been harassed./ppSoldiers took photographs and hair and blood samples before
burying victims in mass graves in the hope that DNA testing might identify bodies in the future.
/ppBut given the devastation wrought by the earthquake, some bodies may never be recovered. In some
cases, there may be few relatives left to identify victims./ppOn top of the 70,000 confirmed dead,
18,000 people are still listed as missing./pp"Most of our cadres and people have overcome the
shadow of the earthquake," Wei said. "They are working hard to rebuild their homes and most have
found balance in their lives."/ppAsked about the suicide of two officials in the quakezone in as
many months, he said: "We recognise that the earthquake has still left some deeply damaged in their
hearts. We are very sympathetic about the suicides, but the reason for the suicides is not just the
trauma but other causes too."/pdiv style="float: left; margin-right: 10px; margin-bottom:
10px;"ullia href="http://www.guardian.co.uk/world/chinaearthquake"China earthquake/a/lilia
href="http://www.guardian.co.uk/world/china"China/a/lilia
href="http://www.guardian.co.uk/world/naturaldisasters"Natural disasters and extreme
weather/a/li/ul/divdiv class="guRssAdvert"a
href="http://ads.guardian.co.uk/click.ng/richmedia=yessite=Newscountry=(none)spacedesc=rsssystem=rsstransactionID=1227280796907112115200444823"img
src="http://ads.guardian.co.uk/image.ng/richmedia=yessite=Newscountry=(none)spacedesc=rsssystem=rsstransactionID=1227280796907112115200444823"
border="0" //a/diva href="http://www.guardian.co.uk"guardian.co.uk/a copy; Guardian News Media
Limited 2008 | Use of this content is subject to our a
href="http://users.guardian.co.uk/help/article/0,,933909,00.html"Terms Conditions/a | a
href="http://www.guardian.co.uk/webfeeds/1,,1309488,00.html"More Feeds/a

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Wooster Collective -
1 days and 1 hours ago
Age: old enough to know better but still young enough to try it.
Hometown:
Dawson City, Yukon Territory, Canada
Where do you now live?: Vancouver B.C. Canada
Where would you most like to live?: Paris, France
Who was your first "hero" in life?: This one is tricky. I'm finding myself
debating the merits of the "hero" in North American culture, how the idea of a hero has become
perverted and maligned, we no longer have a sense of the original intent or meaning of the word.
Not unlike many initially positive and unbinding social constructs it seems to have become a
method solely by which to propagate product; to create desire for that product unbeknownst to the
consumer. More recently the product has been removed from tangibility, it now resides as
ephemera, particularly useful when populations need to be convinced of or swayed towards certain
ideologies. I am thinking specifically of the onslaught of comic book superhero movies that have
been accosting every man woman and child in the last 6 or 7 years. The all rely on the same
formula, the use of an underdog, a freak accident or occurrence beyond their control, the never
ending countdown, the false humility..ect..ect. I suppose what concerns me the most is that these
scenarios are played out with such frequent repetition and magnitude that the effect they must be
having on the children and youth of today is incalculable. Anyway.....never really had any
heroes, if I had to name one it would be Eric Blair. His work got me through some really hard
times as a teen, and still amazes me with its almost prophetic accuracy.
What is your favorite thing to do on your day off from work?: I don't take days
off.
What is your favorite color?: i know its not a colour..black.
Who (or what) do you love?: Kaia, animals, children who aren't afraid ( harder
to come by these days...;{....) old folks who aren't angry, the forest, riding my bike really
fast, making a good piece of art (rare), Europe, film cameras, making music, singing, playing
piano, dreaming ( if they are good dreams) old blues, boy sopranos, being inspired, anything
antique that is mechanical, hand tools.....ummm...lots of stuff..hahhaha!
Wooster: Who and/or what are some of your influences?:
The Renaissance, David Hockney, Caravaggio, Attila Richard Lukacs, Rick Owens, Chuck Close, Arvo
Part, Eric Satie, David Lynch, Gus Van Sant, James Dean, Bernini, B/W film photography, Carl
Jung, Carlos Castaneda, George Orwell, Shakespeare, Jimi Hendrix, William Blake.... there are so
many. too many.
Wooster: What other artists do you most admire?
Currently ..Elbow Toe and Conor Harrington...sooo far ahead of the curve. These ones you might
have to Google, but its worth it...Office Supplies Incorporated, Graeme Berglund, Jeff Petry,
Todd Duym, Meghan Patterson, Ronan Boyle, Tom Anselmi.
Wooster: What other talent would most like to have?
I guess I'm pretty lucky in that department, I have pretty much all the ones I want. I do regret
not taking ballet lessons when I was a kid, I think it's absolutely beautiful. I'd like to be
able to dance like Baryshnikov. That would be really cool.
Wooster: What do you fear the most?
The power of my mind.
Wooster: What is your greatest ambition?
To be written into art history and be an inspiration for the generations to come.
You can see more work by The Dark here and
here.

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Engadget -
1 days and 2 hours ago
div align="center"a
href="http://bits.blogs.nytimes.com/2008/11/20/towering-led-sign-will-light-times-square/?hp"img
vspace="4" hspace="4" border="1"
src="http://www.blogcdn.com/www.engadget.com/media/2008/11/11-20-08-walgreens-led-boar.jpg" alt=""
//abr //div Remember that a
href="http://www.engadget.com/2008/06/05/walgreens-to-erect-largest-sign-in-times-square-use-just-12-mil/"LED
display board/a that was scheduled to be lit up at Walgreens in Times Square? You know, that
17,000-square foot one touting 12 million LEDs? Sure you do. The board, which was designed by D3
LED, was finally activated in the heart of New York City, and its creators are asserting that it's
one of the most complex in existence. If you're wondering if this is worth a trip up (along with
having a peek at the giant tree in Rockefeller Center), you might want to hit the read link first,
but you should probably understand that almost a
href="http://www.engadgethd.com/2008/07/15/toshiba-lights-up-massive-led-hdtv-in-times-square/"nothing
in NYC/a can hold a candle in terms of magnitude to a
href="http://www.engadgethd.com/2008/10/08/worlds-largest-led-screen-coming-to-dubai/"downtown
Dubai/a.pFiled under: a href="http://www.engadget.com/category/displays/" rel="tag"Displays/a/pp
style="padding:5px;background:#ddd;border:1px solid #ccc;clear:both;"a
href="http://www.engadget.com/2008/11/21/gigantic-led-display-board-goes-live-at-walgreens-in-times-squar/"Gigantic
LED display board goes live at Walgreens in Times Square/a originally appeared on a
href="http://www.engadget.com"Engadget/a on Fri, 21 Nov 2008 06:44:00 EST. Please see our a
href="http://www.weblogsinc.com/feed-terms/"terms for use of feeds/a./ph6 style="clear: both;
padding: 8px 0 0 0; height: 2px; font-size: 1px; border: 0; margin: 0; padding: 0;"/h6a
href=http://bits.blogs.nytimes.com/2008/11/20/towering-led-sign-will-light-times-square/?hpRead/anbsp;|nbsp;a
href="http://www.engadget.com/2008/11/21/gigantic-led-display-board-goes-live-at-walgreens-in-times-squar/"
rel="bookmark" title="Permanent link to this entry"Permalink/anbsp;|nbsp;a
href="http://www.engadget.com/forward/1378839/" title="Send this entry to a friend via email"Email
this/anbsp;|nbsp;a
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LE FIGARO - Une -
1 days and 9 hours ago
Un puissant séisme de magnitude 6 est survenu au large des îles Salomon, selon
l'Institut de géophysique américain (USGS), mais aucune victime ni dégât
n'ont été rapporté dans l'immédiat. L'épicentre de la
secousse sous-marine enregistrée a été localisé à 75 km au
nord-ouest de la capitale...
|
Journal of Neuroscience -
1 days and 11 hours ago
Publication Date: 2008 Nov 19 PMID: 19020023br/Authors: Moustafa, A. A. - Cohen, M. X. - Sherman,
S. J. - Frank, M. J.br/Journal: J Neuroscibr/br/Converging evidence implicates striatal dopamine
(DA) in reinforcement learning, such that DA increases enhance Go learning to pursue actions with
rewarding outcomes, whereas DA decreases enhance NoGo learning to avoid non-rewarding actions. Here
we test whether these effects apply to the response time domain. We employ a novel paradigm which
requires the adjustment of response times to a single response. Reward probability varies as a
function of response time, whereas reward magnitude changes in the opposite direction. In the
control condition, these factors exactly cancel, such that the expected value across time is
constant (CEV). In two other conditions, expected value increases (IEV) or decreases (DEV), such
that reward maximization requires either speeding up (Go learning) or slowing down (NoGo learning)
relative to the CEV condition. We tested patients with Parkinson's disease (depleted striatal DA
levels) on and off dopaminergic medication, compared with age-matched controls. While medicated,
patients were better at speeding up in the DEV relative to CEV conditions. Conversely, nonmedicated
patients were better at slowing down to maximize reward in the IEV condition. These effects of DA
manipulation on cumulative Go/NoGo response time adaptation were captured with our a priori
computational model of the basal ganglia, previously applied only to forced-choice tasks. There
were also robust trial-to-trial changes in response time, but these single trial adaptations were
not affected by disease or medication and are posited to rely on extrastriatal, possibly
prefrontal, structures.br/br/post to: a href =
http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19020023title=Entrez+PubmedCiteULike/a

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American Journal of Epidemiology - recent issues -
1 days and 15 hours ago
Polymorphisms in NQO1, a gene coding for the phase II enzyme involved in the
detoxification of quinone carcinogens, have been associated with childhood leukemia in some
studies, although the observed direction and magnitude of effects have been inconsistent.
Therefore, the authors systematically reviewed all published reports describing the effect of
NQO1 in de novo childhood leukemia and conducted a meta-analysis of 7 case-control
studies that examined the association between NQO1*2 and childhood leukemia. Although a
family-based study previously demonstrated overtransmission of this allele among childhood acute
lymphoblastic leukemia cases, the meta-analysis showed that the presence of a NQO1*2
variant allele, which reduces the activity of the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1),
had no significant effect on childhood leukemia. However, there was an increased risk associated
with having at least 1 copy of the NQO1*2 allele in a subset of cases with MLL
translocations (summary odds ratio = 1.39, 95% confidence interval: 0.98, 1.97). Heterogeneity
between studies may be due to differences in population exposures to NQO1 substrates and small
sample sizes, as well as potential population stratification in non-family-based studies.
Therefore, further research is warranted on the role of NQO1 polymorphisms in the
etiology of childhood leukemia, especially among MLL-positive leukemias.

|
Romandie News -
1 days and 23 hours ago
Un séisme d'une magnitude de 2.9 sur l'échelle de Richter a eu lieu le 20 Novembre
2008 à 13:20 en Suisse ( Barberine ). Latitude 46.04N, Longitude ...
|
Romandie News -
1 days and 23 hours ago
Un séisme d'une magnitude de 2.9 sur l'échelle de Richter a eu lieu le 20 Novembre
2008 à 13:20 en Suisse ( Barberine ). Latitude 46.04N, Longitude ...
|
Codestore Activity Log -
2 days and 6 hours ago
Let's say you have a view of support tickets that are awaiting processing. The older the ticket
gets the more important it is that somebody does something about it.
How do we convey this to the user though? Well, there's
various methods, but yesterday I came up with a new way, which I think you'll like. Imagine each
row of the view is a varying shade of red, based on the document's age. The older the document
the redder the row.
You can see an example of this in the screen-grab to the right and in this DEXT demo page. On the demo page you'll need to
scroll down to see it in effect.
How Does It Work?
In terms of CSS this works by virtue of the fact you specify a colour as three numeric values
representing the mix of red, green and blue. You might be used to seeing something like this:
<tr style="background-color:#ff0000;"><td>I should be bathed in
red</td></tr>
But did you know you can also do it like this (in all browsers!):
<tr style="background-color:rgb(255,0,0);"><td>I should be bathed in red
too</td></tr>
An RGB value of 255,0,0 is red, whereas 255,255,255 is white. You can specify any shade of pink
by passing 255 for the Red value and any number for
Green and Blue, as long as they're both the same. See this
table as an example:
rgb(255,0,0) Red rgb(255,60,60) ↑ rgb(255,127,127) Pink rgb(255,200,200) ↓
rgb(255,255,255) White
The smaller the number you specify for Green and Blue the redder the colour. Can you see where
this is going?
How This Works In Domino
What we need to do in our view is have each row calculate a number between 0 and 255. Brand new
documents need to come out of the formula with a value of 255, whereas really old documents need
to compute to 0.
The view itself needs to be treated as HTML and one of the columns would have a formula like
this:
days_passed:=1+(@Date(2008;11;20)-@Date(@Created))/(60*60*24); factor:=20;
val:=@Min(@Round((1/(days/factor))*255); 255); "<tr
style="background-color:rgb(255,"+@Text(val)+",+@Text(val)+");">
As you can see (hopefully) the G and B values of the row colour are worked out as a "percentage"
value of 255, based on how many days have passed since it was created.
The number you multiply 255 by should be somewhere between 0 and 1. If it's 0 then you get red.
if it's 1 then you get white. So it might seem the opposite way round to what you'd expect.
Note that I've introduced a "factor" in to the formula above. What I found was that you need to
spread the shading of your rows out over the range of dates you expect to encounter. The factor
needs to be about the same order of magnitude as the top end date expected. The best way to work
this out is to play with it in your real world scenario.
Using Dates In View Columns
By now you might have noticed the view uses today's date in a column formula. Although the way
I've done doesn't invoke the problems with indexing that using @Today does you might be wondering
how it gets updated, as the date appears hard-coded.
Remember I've talked before about how you can use scheduled agents to
update view selection formula. Well, you can do the same thing with column formulas too!
Imagine this code running every night at shortly past midnight:
Set TodayDT = New NotesDateTime(Now) tmp =
|days_passed:=1+([+TodayDT.DateOnly+|]-@Date(@Created))/(3600*24); factor:=20;
val:=@Min(@Round((1/(days_passed/factor))*255); 255); "<tr
style="background-color:rgb(255,"+@Text(val)+","+@Text(val)+");">"| Set folder =
database.GetView("TicketsByDate") folder.Columns(1).Formula = tmp Call folder.Refresh
It's as easy as that. There's little wonder I'm so fond of Notes.
Summary
Used in the right place this technique can add much usefulness to the user and help them
immediately recognise documents in need of attention. How you use it is down to you (it doesn't
have to be a support ticket system!). It doesn't have to be shades of red either. You can use
shades of any colour, as long as one of the RGB values always stays the same. Brilliant.
Next blog entry will discuss the use of this technique with LotusScript.

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