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This is a guest post by Kathlyn Clore, Associate Editor at the European Journalism
Centre who was kind enough to write this report for us after attending the press event.
A cadre of European politicians gathered Thursday at the Museum of the 18th century in Brussels
to launch Europeana, a digital
museum that allows visitors to explore classic paintings, photos, recordings and texts in the
same manner in which it is possible to search, say, Amazon.com.
Trying to access Europeana on the day of its launch, though, was akin to navigating the Vatican
Museums in the tourist-thick month of August. It was impossible to see anything, as the
project’s three servers were totally overwhelmed.
The Commission said Saturday in a press release that the site received about 10 million hits per
hour throughout Thursday - double server capacity. The site was taken down Friday evening and is
expected to be back up in mid-December.
Europeana’s three servers are located in the Hague, where the project is headquartered, but
programmers plan eventually to put mirror servers around the world.
A pair of Dutchmen programmed Europeana in about 10 weeks, said technical developer Eric Van der
Meulen. They added the final two of 21 European languages, Finnish and Hungarian, at 7 p.m. on
Wednesday.
Europeana, which is still in beta, was programmed using only open source applications, Van der
Meulen said.
“Once we get the thing finished and stabilized, we want to be able to put this down as an
open source application so other people can look at it and go, ‘Ok how did you do
this?,’ and ‘Wow, maybe we can use this for something.’ The future of computing
is open source and not only that but you can get a lot of input from all over the world this
way.”
Technical challenges included harvesting and normalizing metadata from more than 1,000 different
museums and libraries from around Europe. Half of participating cultural heritage institutions so
far are French. The Louvre in Paris, the Institut National de l’Audiovisuel (which
contributed footage shot on French battlefields in 1914) and the Rijksmuseum in Amsterdam are
three of the biggest participating museums.
Europeana is an outgrowth of The
European Library, on which Van der Meulen also worked. But it has in the press been compared
to Google’s Library
Project. Copyright concerns are abundant in all three projects.
Viviane Reding, European commissioner for media, worked to bring the European Digital Library to
fruition prior to realizing Europeana.
Issues of intellectual property will certainly complicate Reding’s goal of adding 10
million more objects over the next two years. The project will receive 2 million Euro over the
next two years for that goal, said European Commission president Jose Manuel Barroso on Thursday.
For now, all objects on Europeana are in the public domain.
Reding said Thursday that she encourages users of the site to ‘remix’ what’s
available. Moving forward, she plans to facilitate dialogue among various stakeholders to find a
way to legally include contemporary works. Nobody wants a black hole when it comes to artifacts
from the 21st century, she stated. In particular, she said she will continue discussions with
books publishers in order to arrange for digitization of orphan works.
The difference between Europeana and existing library projects, though, is in the diversity of
digital objects available on Europeana. Van der Meulen, for example, is able to search the names
of his family members and come to a recording of his uncle’s 1970s rock band, the Makkers,
or photos of his father Leendert Van der Muelen, a world-class cyclist.
“It’s for a lot of people that way,” he said. “Its a fun toy. Everybody
Googles their name, you know. Only with this you get associations with your own name that you
wouldn’t find in Google.”
Crunch Network: CrunchGear
drool over the sexiest new gadgets and hardware.
Category: Utilities
Released: Nov 19, 2008
Price: $2.99
Description:
Fishing can be difficult but knowing how to tie your knot securely is very important. You must
securely tie your line to your reel and your hooks, lures, and other tackles to your line.
iFishinKnots covers the top ten fishing knots to meet every fishing need in a manner that makes
learning to tie them pretty much straight forward from your iPhone. It is not necessary to know how
to tie a lot of knots but it is important to know how to tie a few essential good ones, and to know
which knots suit the material being used. It is suggested that you select only those few knots that
are of greatest use to you, and practise tying them until they become second nature to you. The
weakest link between the fish and you is the knot; hence a few hours of practise tying a knot will
make the difference. Remember this,
it�s
not the hook, not the line or other terminal tackle,
it�s
the knot that will land you the
�catch
of the
day�.
Why settle for knot printed on paper or bulky books? Get 10 best fishing knots on the iPhone.
Features: * The most important top ten knots used in fishing including the illustrations and
animations.* To tie the knot follows the step by step illustrations or watch an animations to see
the visual steps.* Help page. Disclaimer: Activities involving fishing lines and knots may not be
that potentially life-threatening or dangerous, but when tying knots for anything, always ensure
that the knots are made to do what they supposed to do and tied correctly. Many factors cannot be
controlled such as the choice of materials; the age, size, or condition of the fishing line; as
well as the accuracy of how the knots have been tied. Hence, no responsibility is assumed by
2MoroSoft for incidents arising from the use of iFishinKnots.
Note: The description above is the official one supplied by the application
developer and does not necessarily represent the views or opinions of this site or its staff.
br /What it doesbr /br /Online polls and surveys stand as one of the most direct ways of spicing
interest and getting to know more about those who are part of your community. Presented by Boost
New Media, Sonar is a web-hosted application that will let you create and publish questionnaires to
these purposes. br brThe polls that can be created using Sonar come complete with a wide host of
features, and they can be configured in order to meet your demands. For instance, you can choose
which type of questions you want to ask, and in this case you can have your pick from multi-choice
and open-ended questions. Moreover, it is possible to nominate a set time for polling. In this
case, a start and finish time can be specified. br brOn the other hand, the registration process
for panelists is an easy one, and it is dealt with in a more or less instant manner. Interaction
with panelists is further bolstered by enabling them to receive notifications about poll results
and upcoming questionnaires. br brPricing information is included on the site, and you can always
resort to the featured online demo. In addition to that, you can schedule a personal demonstration
by contacting the team at the address that is provided.br /br /Some questionsbr /br /Are examples
and tutorials provided at the site?br /br /In their own wordsbr /br /“Online polls are an
effective way of gathering information and engaging with your community. Sonar will help you get
the most out of the process with a consultation website that looks good and is easy to use and
administer.” br /br /Why it might be a killerbr /br /It is a practical solution that is
wholly web-based.br /br /Link: a href='http://www.sonarhq.com'http://www.sonarhq.com/abr /Our
Review: a
href='http://www.killerstartups.com/Web-App-Tools/sonarhq-com-online-consultations-made-easy'http://www.killerstartups.com/Web-App-Tools/sonarhq-com-online-consultations-made-easy/abr
/br / nbsp;div class="feedflare" a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=ozcRBPPN"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?d=41" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=49AuZgJb"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?d=52" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=KAwzxXpa"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?i=KAwzxXpa" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=rRGrPVRl"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?i=rRGrPVRl" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=YirOAlGN"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?d=43" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=wi7dMX6w"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?i=wi7dMX6w" border="0"/img/a /divimg
src="http://feedproxy.google.com/~r/killerstartups/BkQV/~4/Q-0YFIXRQAo" height="1" width="1"/
Publication Date: 2008 Nov 20 PMID: 19020623br/Authors: Hanna, R. A. - Campbell, R. L. - Davies, P.
L.br/Journal: Naturebr/br/Calpains are non-lysosomal calcium-dependent cysteine proteinases that
selectively cleave proteins in response to calcium signals and thereby control cellular functions
such as cytoskeletal remodelling, cell cycle progression, gene expression and apoptotic cell death.
In mammals, the two best-characterized members of the calpain family, calpain 1 and calpain 2
(micro-calpain and m-calpain, respectively), are ubiquitously expressed. The activity of calpains
is tightly controlled by the endogenous inhibitor calpastatin, which is an intrinsically
unstructured protein capable of reversibly binding and inhibiting four molecules of calpain, but
only in the presence of calcium. To date, the mechanism of inhibition by calpastatin and the basis
for its absolute specificity have remained speculative. It was not clear how this unstructured
protein inhibits calpains without being cleaved itself, nor was it known how calcium induced
changes that facilitated the binding of calpastatin to calpain. Here we report the 2.4-A-resolution
crystal structure of the calcium-bound calpain 2 heterodimer bound by one of the four inhibitory
domains of calpastatin. Calpastatin is seen to inhibit calpain by occupying both sides of the
active site cleft. Although the inhibitor passes through the active site cleft it escapes cleavage
in a novel manner by looping out and around the active site cysteine. The inhibitory domain of
calpastatin recognizes multiple lower affinity sites present only in the calcium-bound form of the
enzyme, resulting in an interaction that is tight, specific and calcium dependent. This crystal
structure, and that of a related complex, also reveal the conformational changes that calpain
undergoes on binding calcium, which include opening of the active site cleft and movement of the
domains relative to each other to produce a more compact enzyme.br/br/post to: a href =
http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19020623title=Entrez+PubmedCiteULike/a
Every time I scroll through my list of ‘Friends’ on Facebook, I inevitably come to
the same (somewhat depressing) conclusion: I have absolutely no idea who many of these people
are. This is mostly my fault - my standards have always been pretty low when it comes to
accepting inbound requests, and I never kept up with assigning them to appropriate Friends Lists.
But there’s also the fact that Facebook doesn’t do much to automatically
differentiate between friends and acquaintances (while it does filter your News Feed based on who
it thinks you’re interested in, there isn’t a way to automatically generate a list of
“good friends” versus everyone else).
Meezoog, an Israeli
startup backed by veteran VC Yossi Vardi, is looking to help differentiate between acquaintances
and close friends. Today the company has launched its own social network at Meezoog.com that
attempts to determine how strong the connections are between users by analyzing their
relationships on other sites across the web (it also asks you to manually input your relationship
with each friend, but this isn’t required). The site presents a number of
“paths” connecting you with each friend in a manner similar to Six Degrees of Kevin
Bacon, that helps users determine the degree of “social trust” they have with
each user. At this point it’s too early to tell how well the system works, but it’s a
step in the right direction.
Besides its social network, Meezoog also plans to offer Facebook and OpenSocial applications that
allow users to estimate the nature of their connections with their friends, even if they
aren’t on Meezoog’s network. This cross-network analysis is probably the
company’s best shot at success - while Meezoog may be able to establish its standalone
social network in some regional areas, it will have a very hard time directly competing with
established networks like Facebook and MySpace.
Other companies have tried to do similar social connection strength mapping, including Linking Universe.
Crunch Network: MobileCrunch
Mobile Gadgets and Applications, Delivered Daily.
Publication Date: 2008 Nov 19 PMID: 19020042br/Authors: Karunakaran, S. - Saeed, U. - Mishra, M. -
Valli, R. K. - Datt Joshi, S. - Meka, D. P. - Seth, P. - Ravindranath, V.br/Journal: J
Neuroscibr/br/Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by
the degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc).
Activation of the mixed lineage kinase and c-Jun N-terminal kinase (JNK) has been reported in
models of PD. Our focus was to discern whether distinct pathways were activated in cell-specific
manner within the SNpc. We now demonstrate the selective phosphorylation of p38 MAP kinase within
the dopaminergic neurons, whereas JNK activation occurs predominantly in the microglia. p38
activation results in downstream phosphorylation of p53 and increased p53 mediated transcription of
Bax and Puma in the ventral midbrain. Treatment with p38 inhibitor, SB239063 protected primary
dopaminergic neurons derived from human progenitor cells from MPP(+) mediated cell death and
prevented the downstream phosphorylation of p53 and its translocation to the nucleus in vivo, in
the ventral midbrain. The increased staining of phosphorylated p38 in the surviving neurons of SNpc
in human brain sections from patients with PD and in MPTP treated mice but not in the ventral
tegmental area provides further evidence suggesting a role for p38 in the degeneration of
dopaminergic neurons of SNpc. We thus demonstrate the cell specific activation of MAP kinase
pathways within the SNpc after MPTP treatment emphasizing the role of multiple signaling cascades
in the pathogenesis and progression of the disease. Selective inhibitors of p38 may therefore, help
preserve the surviving neurons in PD and slow down the disease progression.br/br/post to: a href =
http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19020042title=Entrez+PubmedCiteULike/a
Remember when Kanye West
threatened to make an album where he would bear his heartbroken soul, align with T-Pain, sing on
every song with the then inescapable Auto-Tune effect and, less problematically, lean on the
common element — the Roland TR-808 drum machine — of classics like “Make It
Last Forever,” “Posse on Broadway,” “808,” and “Bossy”?
It would have been a wreck, a case of an artist working through paralyzing heartache while loose
in a toy store. Except West wasn’t joking. Not only did he go through with it, but
Roc-A-Fella released the result in time for the 2008 Christmas shopping season. It was indeed a
wreck, if a kind of fascinating one, which helped make the material — voiced by someone who
could not really sing, whose substantial shortcomings were not made less obvious by a polarizing
studio device — seem a little less difficult on the ears.
In various spots across 808s &
Heartbreak, the constant flutter of West’s processed voice, along with a seldom
interrupted sluggish march of aching sounds, is enlivened by the disarming manner in which
despair and dejection are conveyed. When, in “Welcome to Heartbreak,” he
dispassionately recounts sitting alone on a flight, ahead of a laughing family, he makes first
class sound like Siberia; he’d swap lives with the father in an instant. The majority of
the lyrics, however, are directed at an ex who evidently did some damage; in
“RoboCop” alone, she gets compared to the antagonist in Misery and is called
a “spoiled little L.A. girl.” Earlier in the album, the number she did on him is
called “the coldest story ever told,” yet he admits he still fantasizes about her.
All the blocky drums, dragging strings, droning synths, and joyless pianos lead to a bleak set of
productions — even the synthetic calliope in “Heartless” is unnerved, and the
relative pep of “Paranoid” provides no respite, its bitter lyrics subverting a
boisterous beat. Several tracks have almost as much in common with irrefutably bleak post-punk
albums, such as New Order’s Movement and the Cure’s Pornography, as contemporary rap and R&B. (”Coldest Winter,”
where West longs for his departed mother, samples the most desolate song from the first
Tears for Fears album.) For anyone sifting through a broken relationship and self-letdown,
this could all be therapeutic. Otherwise, no matter its commendable fearlessness, the album is a
listless, bleary trudge along West’s permafrost.
Publication Date: 2008 Nov 20 PMID: 19020614br/Authors: Ip, S. C. - Rass, U. - Blanco, M. G. -
Flynn, H. R. - Skehel, J. M. - West, S. C.br/Journal: Naturebr/br/Four-way DNA intermediates, also
known as Holliday junctions, are formed during homologous recombination and DNA repair, and their
resolution is necessary for proper chromosome segregation. Here we identify nucleases from
Saccharomyces cerevisiae and human cells that promote Holliday junction resolution, in a manner
analogous to that shown by the Escherichia coli Holliday junction resolvase RuvC. The human
Holliday junction resolvase, GEN1, and its yeast orthologue, Yen1, were independently identified
using two distinct experimental approaches: GEN1 was identified by mass spectrometry following
extensive fractionation of HeLa cell-free extracts, whereas Yen1 was detected by screening a yeast
gene fusion library for nucleases capable of Holliday junction resolution. The eukaryotic Holliday
junction resolvases represent a new subclass of the Rad2/XPG family of nucleases. Recombinant GEN1
and Yen1 resolve Holliday junctions by the introduction of symmetrically related cuts across the
junction point, to produce nicked duplex products in which the nicks can be readily
ligated.br/br/post to: a href =
http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19020614title=Entrez+PubmedCiteULike/a
How to Become a LEGO
Millionaire
The economy may be in the tank, but collectors of rare goods will always be doing well when there
are obsessed people in need of special pieces. And that includes LEGO.
a
href="http://blog.makezine.com/archive/2008/11/best_of_geekdad_lego_rpgs.html?CMP=OTC-0D6B48984890"
/Read more/a | a
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articles in Online/a | a
href="http://digg.com/submit?url=blog.makezine.com%2Farchive%2F2008%2F11%2Fbest_of_geekdad_lego_rpgs.htmltitle=Best%20of%20GeekDad%20-%20LEGO%2C%20RPGs%2C%20Back%20to%20the%20Future%20anbodytext=%20Here%20ya%20go%2C%20best%20of%20GeekDad%20for%20the%20week%21%20How%20to%20Become%20a%20LEGO%20Millionaire%20The%20economy%20may%20be%20in%20the%20tank%2C%20but%20collectors%20of%20rare%20goods%20will%20always%20be%20doing%20well%20when%20there%20are%20obsessed%20people%20in%20need...topic=tech_news"
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Disney Fights Piracy on Site it Funded; 56.com, funded by Steamboat Ventures had
bootlegged Disney content like full-length copies of WALL-E up on the site. (The Wall Street Journal)
YouTube Testing HD Videos; video giant stealthily trying out the higher quality
720p format. (Epicenter
Blog) CNET teaches how to tweak your YouTube embeds for
HD playback.
BitGravity Launches Multi-View, Will Be Used on Diggnation; viewers can
choose from five different simultaneous video streams of the show. (emailed release)
BBC’s Local Video Plan Blocked; regulators say the the $100 million
project to add video bulletins to 65 local UK web sites would hurt video efforts of struggling
local newspapers. (paidContent)
DVD Sales Are Down; sales of the shiny discs off 9 percent during the third
quarter, Blu-Ray’s prospects even bleaker. (The New York Times)
Justin Timberlake’s SNL Skit Pulled Because of Music Clearances;
embeds of the Single Ladies sketch did disappear, but not because Timberlake wanted more
money. (LA
Times)
Mr. Internet Wants to Be the “Talk Soup” of Web Culture; created by
agency Crispin, Porter + Bogusky show will collect all manner of web-based stories and air on
Plum TV. (MediaWeek)
centerimg title="Creative Zen Moo" style="MARGIN: 0px" alt="Creative Zen Moo"
src="http://www.ubergizmo.com/photos/2008/11/creative-moo.jpg" border="0" //centerbr / pHas
Creative finally failed to live up to its namesake, with the latest MP3 player from the Singaporean
company being named "Moo"? Well, perhaps they're trying to tap into a much younger and less mature
demographic. After all, the Creative Zen Moo comes in the form factor of a cow's face, and looks to
feature a similar set of functions found in the Zen Stone, including a tiny OLED display, 2B of
internal memory, 20 hour playback time and an integrated FM tuner. The Creative Zen Moo was
specially designed in this manner to pay a tribute to the year of the cow in the Chinese zodiac
calendar for 2009. /p pPermalink: a
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Arts Antiquities Dealer Seeks Personal Assistantbr / (Downtown Toronto – to start as
early as Dec 1st)br / br / Must possess:br / br / Excellent telephone manner and letter-writing
skillsbr / Superior computer skills (PC)br / Driver's Licensebr / Passportbr / No pet allergiesbr /
25-30 hours/weekbr / Flexible schedule – pay to be negotiatedbr / br / Please send
resume to gk2002@sympatico.ca or fax it to 416.596.2464br / br /
div style="FLOAT: right"img title="Acoustic Research Decorative Speaker Covers" alt="Acoustic
Research Decorative Speaker Covers" hspace="5"
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//div pSpeaker design is extremely subjective, and not all of them come in an aesthetically
pleasing manner. Good thing Acoustic Research wants to change this trend with its new decorative
speaker covers. This home improvement idea allows you to hide your speaker in a a
href="http://www.acoustic-research.com/homedecor/HomeDecorProductDetail.do?ACTION_TYPE_ID=ACTION_TYPE_PRODUCT_DETAILamp;ACTION_CATEGORY_ID=STR_CATEGORY_HOME_DECOR_SPEAKER_COVER_PACKAGESamp;ACTION_PRODUCT_ID=HDK2"wicker
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suffering too much degradation in sound quality. Those who deal with larger speakers can always
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src="http://feedproxy.google.com/~f/ubergizmo?d=41" border="0"/img/a a
href="http://feedproxy.google.com/~f/ubergizmo?a=XaluvLb6"img
src="http://feedproxy.google.com/~f/ubergizmo?i=XaluvLb6" border="0"/img/a a
href="http://feedproxy.google.com/~f/ubergizmo?a=hfcsQpYj"img
src="http://feedproxy.google.com/~f/ubergizmo?d=52" border="0"/img/a a
href="http://feedproxy.google.com/~f/ubergizmo?a=82L46rze"img
src="http://feedproxy.google.com/~f/ubergizmo?i=82L46rze" border="0"/img/a a
href="http://feedproxy.google.com/~f/ubergizmo?a=LNjrEiSZ"img
src="http://feedproxy.google.com/~f/ubergizmo?i=LNjrEiSZ" border="0"/img/a /div
Publication Date: 2008 Nov 19 PMID: 19020036br/Authors: Schock, S. C. - Xu, J. - Duquette, P. M. -
Qin, Z. - Lewandowski, A. J. - Rai, P. S. - Thompson, C. S. - Seifert, E. L. - Harper, M. E. -
Chen, H. H.br/Journal: J Neuroscibr/br/Activation of peroxisome proliferator-activated
receptor-gamma (PPARgamma) signaling after stroke may reduce brain injury, but this effect will
depend on the levels of receptor and cofactors. Here, we showed that the direct effect of PPARgamma
signaling to protect neurons from ischemic injury requires a novel cofactor LMO4, because this
effect was lost in LMO4-null cortical neurons. PPARgamma agonist also failed to reduce cerebral
infarction after transient focal ischemia in CaMKIIalphaCre/LMO4loxP mice with LMO4 ablated in
neurons of the forebrain. Expressing LMO4 in LMO4-null cortical neurons rescued the
PPARgamma-protective effect. PPARgamma signaling activates the promoter of the antioxidant gene
SOD2 and this process requires LMO4. Addition of a superoxide dismutase mimetic MnTBAP
[manganese(III)tetrakis(4-benzoic acid)porphyrin] bypassed the deficiency in PPARgamma signaling
and was able to directly rescue LMO4-null cortical neurons from ischemic injury. Like LMO4,
PPARgamma and PGC1alpha (PPARgamma coactivator 1alpha) levels in neurons are elevated by hypoxic
stress, and absence of LMO4 impairs their upregulation. Coimmunoprecipitation and mammalian
two-hybrid assays revealed that LMO4 interacts in a ligand-dependent manner with PPARgamma. LMO4
augments PPARgamma-dependent gene activation, in part, by promoting RXRalpha (retinoid X
receptor-alpha) binding to PPARgamma and by increasing PPARgamma binding to its target DNA
sequence. Together, our results identify LMO4 as an essential hypoxia-inducible cofactor required
for PPARgamma signaling in neurons. Thus, upregulation of LMO4 expression after stroke is likely to
be an important determinant of neuron survival.br/br/post to: a href =
http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19020036title=Entrez+PubmedCiteULike/a
br /What it doesbr /br /Can’t seem to manage time in a satisfactory manner? Need some help
getting self-organized? You can always count on the man web-based solutions that are doing the
rounds to these ends, and BubbleTimer is one such application. br brBasically, it will let you keep
track of different tasks and see how you allocate your time regularly, so that you will be able to
figure out what activities should be carried out differently. Moreover, you can easily set goals
and see how you fare as the day or week progresses. If you wish, it is even possible to share this
information over the web with other people like members of your family and so on. br brThis tool
comes at a set price that is listed on the site, but you can also try it out beforehand in order to
determine if it is the right application for you or not. In any case, there is no need to download
anything – you simply sign up online and start using the application right away.
brbr /br /In their own wordsbr /br /“BubbleTimer helps you spend your time on what's most
important to you.”br /br /Why it might be a killerbr /br /It is an easy-to-implement
application that that does what it sets out to do in a concise way.br /br /Some questionsbr /br
/How much does it cost?br /br /Link: a
href='http://www.bubbletimer.com'http://www.bubbletimer.com/abr /Our Review: a
href='http://www.killerstartups.com/Web-App-Tools/bubbletimer-com-time-management-solution'http://www.killerstartups.com/Web-App-Tools/bubbletimer-com-time-management-solution/abr
/br / nbsp;div class="feedflare" a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=6TvgNB1s"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?d=41" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=jDU0ztY9"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?d=52" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=UY79mXq9"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?i=UY79mXq9" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=bP4l38Sh"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?i=bP4l38Sh" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=vpb3kh4m"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?d=43" border="0"/img/a a
href="http://feedproxy.google.com/~f/killerstartups/BkQV?a=vQxIdITK"img
src="http://feedproxy.google.com/~f/killerstartups/BkQV?i=vQxIdITK" border="0"/img/a /divimg
src="http://feedproxy.google.com/~r/killerstartups/BkQV/~4/r95b81e-O64" height="1" width="1"/
Publication Date: 2008 Nov 19 PMID: 19020034br/Authors: Tung, Y. C. - Ma, M. - Piper, S. - Coll, A.
- O'Rahilly, S. - Yeo, G. S.br/Journal: J Neuroscibr/br/Leptin plays a major role in coordinating
the integrated response of the CNS to changes in nutritional state. Neurons within the
paraventricular nucleus (PVN) of the hypothalamus express leptin receptors and receive dense
innervation from leptin receptor-expressing neurons in the arcuate nucleus. To obtain new insights
into the effects of circulating leptin on PVN function, we compared global transcriptional profiles
of laser-captured PVN from ad libitum fed mice versus 48 h fasted mice receiving either sham or
leptin treatment intraperitoneally. Five hundred twenty-seven PVN-expressed genes were altered by
fasting in a manner that was at least partially reversible by leptin. Consistent with previous
reports, thyrotrophin releasing hormone mRNA levels were decreased by fasting but restored to fed
levels with leptin treatment. mRNA levels of oxytocin, vasopressin, and somatostatin were also
reduced by fasting and restored by leptin. Given the known effects of leptin on synaptic
remodeling, it is notable that, among the top 15 genes that were positively regulated by leptin,
five have been implicated in synaptic function and/or plasticity (basigin, apolipoprotein E, Gap43,
GABA(A) receptor-associated protein, and synuclein-gamma). Pathway analysis identified oxidative
phosphorylation, in particular, genes encoding complex 1 proteins that play a role in ubiquinone
biosynthesis, to be the predominant gene set that was significantly regulated in a leptin-dependent
manner. Thus, in addition to its effects on the expression of a broad range of neuropeptides,
leptin may also exert more general influences on synaptic function in, and the bioenergetic state
of, the PVN.br/br/post to: a href =
http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19020034title=Entrez+PubmedCiteULike/a
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src="http://www.youtube.com/v/vQL0tqLCjcQhl=enfs=1" type="application/x-shockwave-flash"
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height="400"/embed/objectMercedes-Benz new myCOMAND system has appeared at the a
href="http://jalopnik.com/tag/la-auto-show/"Los Angeles Auto Show/a, taking on the a
href="http://gizmodo.com/5070122/bmw-idrive-40-remixes-xbox-360-and-ipod-into-simpler-control-system"fourth-generation
BMW iDrive/a. Whereas the latter has an Xbox 360 feeling, this one gets some clues from Apple's,
specially Coverflow and the menu navigation, which reminds me of the first version of the Apple TV
and Front Row. One big difference is that myCOMAND is connected to the web, grabbing information
wirelessly and presenting it through their own on-screen apps. Looking at the high resolution
screens and the feature list, it looks very good:/p pscript type="text/javascript"
charset="utf-8"galleryPost('mycomand', 3, '');/script/p p· Off-board navigation: The GPS is
constantly updated, from the maps to the points of interests. It also has a satellite overview and
the search language is open: you can write directions without having to follow a format. It looks
like the are plugging into Google Maps for this one, although I'm not sure how well the writing
will work using their navigation knob./p p· Trip assist: This part is quite nice, grabbing
information pertaining your planned trip from different web sources and presenting it in a useful
manner. You can, for example, see the weather forecast for the trip, as well as giving you the
possibility to make hotel and restaurants reservations from the system itself./p p· World
radio: Instead of using a normal radio, this one plugs into the web to access all the stations
available. The menu gives the possibility to access radio via genre. More interesting is the idea
of storing your music in a web server and accessing it through the system directly, without the
need to connect an digital music player or storing things locally./p p· Internet telephony:
It has support for voice over IP systems like Skype./p p· Web browser: They also include a
web browser, in case you need to get more information than the one provided with the thin clients
above./p p· YouTube: For huh... hmmm. iSome/i r
)
and reject those that you are not interested in
(
)
Category: Utilities
Remember when Kanye West
threatened to make an album where he would bear his heartbroken soul, align with T-Pain, sing on
every song with the then inescapable Auto-Tune effect and, less problematically, lean on the
common element — the Roland TR-808 drum machine — of classics like “Make It
Last Forever,” “Posse on Broadway,” “808,” and “Bossy”?
It would have been a wreck, a case of an artist working through paralyzing heartache while loose
in a toy store. Except West wasn’t joking. Not only did he go through with it, but
Roc-A-Fella released the result in time for the 2008 Christmas shopping season. It was indeed a
wreck, if a kind of fascinating one, which helped make the material — voiced by someone who
could not really sing, whose substantial shortcomings were not made less obvious by a polarizing
studio device — seem a little less difficult on the ears.
