pThe home secretary, Jacqui Smith, is to make a Commons statement today on the arrest of the Tory frontbencher Damian Green. Senior political correspondent strongAndrew Sparrow/strong assesses the implications of yesterday's allegations from the Speaker, Michael Martin, that the police didn't have a search warrant before they entered Green's Commons office - and failed to inform Commons officials that they were entitled to ask for one./ppHome affairs editor, strongAlan Travis/strong, looks at a new government advertisement warning young people of the perils of cocaine./ppstrongChris McGreal/strong reports from Harare on the breakdown of order in Zimbabwe, with the economy destroyed, public employees joining street protests, and an epidemic of cholera./ppEach year 35m items of post go undelivered because the sender hasn't written the address clearly. The letters, parcels and packages find their way to a sorting centre in Belfast, from where strongHenry McDonald/strong reports./ppThe New Yorker music critic strongAlex Ross/strong was named last night as the winner of the Guardian First Book Award for The Rest is Noise: Listening to the Twentieth Century, a tour de force through 100 years of classical music./ppAnd X-Factor star strongRachel Hylton/strong talks to G2's strongHannah Pool/strong./p pa href="http://feedads.googleadservices.com/~at/1rgyzSwEAfEtdrxI3vlgLIWUn8I/a"img src="http://feedads.googleadservices.com/~at/1rgyzSwEAfEtdrxI3vlgLIWUn8I/i" border="0" ismap="true"/img/a/p

Publication Date: 2008 Dec 1 PMID: 19046431br/Authors: Oscamou, M. - McDonald, D. - Yap, V. B. - Huttley, G. A. - Lladser, M. E. - Knight, R.br/Journal: BMC Bioinformaticsbr/br/ABSTRACT: BACKGROUND: The nucleotide substitution rate matrix is a key parameter of molecular evolution. Several methods for inferring this parameter have been proposed, with different mathematical bases. These methods include counting sequence differences and taking the log of the resulting probability matrices, methods based on Markov triples, and maximum likelihood methods that infer the substitution probabilities that lead to the most likely model of evolution. However, the speed and accuracy of these methods has not been compared. RESULTS: Different methods differ in performance by orders of magnitude (ranging from 1 ms to 10 s per matrix), but differences in accuracy of rate matrix reconstruction appear to be relatively small. Encouragingly, relatively simple and fast methods can provide results at least as accurate as far more complex and computationally intensive methods, especially when the sequences to be compared are relatively short. CONCLUSIONS: Based on the conditions tested, we recommend the use of method of Gojobori et al. (1982) for long sequences (300 nucleotides), and the method of Goldman et al. (1996) for shorter sequences (300 nucleotides). The method of Barry and Hartigan (1987) can provide somewhat more accuracy, measured as the Euclidean distance between the true and inferred matrices, on long sequences (2000 nucleotides) at the expense of substantially longer computation time. The availability of methods that are both fast and accurate will allow us to gain a global picture of change in the nucleotide substitution rate matrix on a genomewide scale across the tree of life.br/br/post to: a href = http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19046431title=Entrez+PubmedCiteULike/a

Offers supposedly from McDonalds, Coca-Cola, and Hallmark are spreading a new mass-mailing worm, say security vendors.

Offers supposedly from McDonalds, Coca-Cola, and Hallmark are spreading a new mass-mailing worm, say security vendors.

Nevidljivi automobil u McDonald's Driv In-u na Fontani. Invisible car in McDonald's Drive In Belgrade.

Author: kpknb Keywords: Fontana McDonalds Beograd Added: December 3, 2008

pimg src="http://cache.gawker.com/assets/images/gizmodo/2008/12/santa-claus-gmail-account.jpg" align="left" hspace="4" vspace="2" width="850" height="614" style="display:block;float:none;" /I love this isantaclaus@gmail.com/i snapshot, from Bono in his contacts, along with Jesuschrist and Rudolph, to the fact that he'll give Xboxes instead of coal because of the energy crisis or God wanting a Wii. His inbox is a must./p pI want to read the rest of these:/p p· Yahoo! Answers Answer-Jim311 responded to: "Can Elves get Pregnbr · Frosty The Snowman. Dude-Check it. I snapped a pic of this chick that I fubr · George W. Bush. Dear santa-Can I have t third term? I promise I'll bbr · Ronald McDonald. I wish-I had your cred man. I can do more than sellbr · Elfbang.com. Your subscription-We renewed your subscription to the hottest elf on elf action i[Someone actually registered this domain name. Yes, I tried it.]/ibr · Al Gore, me (7) Re: My Movie-Still haven't watched it yet? It affects you too, the polar ice c/p pIn any case, I'm just glad that a href="http://gizmodo.com/gadgets/santa-arrested-by-imperial-stormtroopers/imperial-stormtroopers-arrest-santa-emperor-to-take-over-xmas-334460.php"Santa escaped his imperial imprisonment/a. [a href="http://www.holytaco.com/santas-gmail-account"Holy Taco/a via a href="http://www.holytaco.com/santas-gmail-account"/a]a href="http://www.walyou.com/blog/2008/12/02/the-gmail-account-of-santa-claus/"Walyou/a]/p pbMore fakemodos/bbr · a href="http://gizmodo.com/5024372/apple-cancels-all-iphone-3g-orders-releases-ibrick-3g"Apple Cancels All iPhone 3G Orders, Releases iBrick 3G/abr · a href="http://gizmodo.com/5015395/apple-introduces-iphone-3g-videoconferencing-kit-zomg"Apple Introduces iPhone 3G Videoconferencing Kit, ZOMG!/abr · a href="http://gizmodo.com/392495/indiana-jones-theme-secret-lyrics-uncovered"Indiana Jones' Theme Secret Lyrics Uncovered/abr · a href="http://gizmodo.com/345406/apple-introduces-manila-casethe-worlds-thinnest-notebook-case"Apple Introduces Manila Case—The World's Thinnest Notebook Case/a/p br style="clear: both;"/ a href="http://www.pheedo.com/feeds/ht.php?t=camp;i=0a575382d78eeab91fa4cd78a55a6904amp;p=1"img style="border:0;" src="http://www.pheedo.com/feeds/ht.php?t=vamp;i=0a575382d78eeab91fa4cd78a55a6904amp;p=1" border="0" //adiv class="feedflare" a href="http://feeds.gawker.com/~f/gizmodo/full?a=RX1G7vss"img src="http://feedproxy.google.com/~f/gizmodo/full?d=120" border="0"/img/a a href="http://feeds.gawker.com/~f/gizmodo/full?a=yshBuUzY"img src="http://feedproxy.google.com/~f/gizmodo/full?d=41" border="0"/img/a a href="http://feeds.gawker.com/~f/gizmodo/full?a=HdLgJ1sX"img src="http://feedproxy.google.com/~f/gizmodo/full?i=HdLgJ1sX" border="0"/img/a a href="http://feeds.gawker.com/~f/gizmodo/full?a=0LDglWwI"img src="http://feedproxy.google.com/~f/gizmodo/full?i=0LDglWwI" border="0"/img/a /divimg src="http://feedproxy.google.com/~r/gizmodo/full/~4/fQA49N2kqJg" height="1" width="1"/

img src="http://i.eurosport.fr/2008/12/03/484522-3732386-458-238.jpg" alt=" Arsenal s'arrête là"/br/ Arsenal, qui alignait une équipe fortement rajeunie, s'est incliné devant Burnley en quarts de finale de la Carling Cup, la Coupe de la Ligue anglaise. Le milieu écossais Kevin McDonald a inscrit les deux buts qui ont crucifié les jeunes pousses londoniennes, en panne de réalisme.

Matthew Herbert is a musician obsessed with real life sound effects. He has combined a range of unusual noises together with a big band and tried to create a sound that reflects the use and abuse of power. Reporter Nicola Stanbridge listens to the sound effects, which include the shooting of a man, a cremation and secret recordings in the Houses of Parliament. nbsp; nbsp; Restless innovator, sampling wizard, classically trained pianist and superstar collaborator, MATTHEW HERBERT is one of electronic music's most versatile and prolific figureheads. Recording under his own name as well as Doctor Rockit, Wishmountain, Radio Boy and others, Herbert has also produced and remixed artists as diverse as Björk, REM, John Cale, Roisin Murphy, Yoko Ono and Serge Gainsbourg. nbsp; nbsp; An alchemist of avant-garde sound in the tradition stretching from Stockhausen to the Aphex Twin, Herbert combines playful pop sensibility with a strictly imposed experimental agenda. In his increasingly conceptual and political albums he has emerged as a unique figure in modern music: a kind of one-man Radiohead, or a Brian Eno for the 21st century. nbsp; nbsp; It was in January 1995 that Herbert gave his first large public performance. His instruments: a sampler and a bag of crisps. But long before he discovered the revolutionary possibilities of sampling, he began playing violin and piano at the age of four. When he was seven he sang in the school choir and played with orchestras. At school, he had the good fortune to have a music teacher who considered Reich, Xenakis and Jazz standards to be the equal of Beethoven. During his time as a theatre student at Exeter University, Herbert, the son of a BBC sound technician, continued to invest in his own home studio. nbsp; nbsp; a HREF=http://www.matthewherbert.com/music.phpstreamed music by M.H./a

Fast Forward 2 is the second volume in Lou Anders' excellent science fiction anthology series, featuring knockout stories from Karl Schroeder and Tobias Buckell, Kay Keyon, Ian McDonald, Paolo Bacigalupi and many others. I'm very proud to have a story in the book, too -- a long, long novella I co-wrote with Ben Rosenbaum called True Names, which tries to imagine what the wars between light-speed-lagged, self-replicating nano-machine-based galactic civilizations would look like as different nanites warred to see who would convert the universe to computronium first. While all the stories herein are at least excellent, there were a couple of absolute knockouts that I want to mention. First is Toby Buckell and Karl Schroeder's Mitigation, a taught military thriller about the global geopolitics of genomic seedbanks. Also fantastic is Ian McDonald's Eligible Boy, which returns to the fractured future India he delivered in his brilliant, Hugo-nominated novel, River of Gods, and explores the hard problem of matchmaking in an era of demographics upturned by gendercide. Finally, Paolo Bacigalupe's The Gambler should be required reading at every school of journalism in the world, exploring as it does the question of click-driven news and coming up with genuinely novel and sometimes disturbing things to say about it. Lou's posted two of the stories from the anthology online as free samples: "Catherine Drewe" by Paul Cornell" and Paolo Bacigalupi's "The Gambler". I'm especially fond of this latter, as I mentioned above. I'm delighted to announce that Ben and I are releasing True Names today as a Creative Commons Attribution-NonCommercial-ShareAlike download, to accompany the podcast of the story we released earlier this year. I hope you'll give it a read, and a remix -- I can't remember when I've had more fun writing anything. (How's this for embarrassing: none of us can find an editable file with the final, copyedited text, just the PDF from the book. There's a remix-challenge for ya: turn the PDF back into ASCII or HTML or something sensible!) Beebe fried the asteroid to slag when it left, exterminating millions of itself. The asteroid was a high-end system: a kilometer-thick shell of femtoscale crystalline lattices, running cool at five degrees Kelvin, powered by a hot core of fissiles. Quintillions of qubits, loaded up with powerful utilities and the canonical release of Standard Existence. Room for plenty of Beebe. But it wasn't safe anymore. The comet Beebe was leaving on was smaller and dumber. Beebe spun itself down to its essentials. The littler bits of it cried and pled for their favorite toys and projects. A collection of civilization-jazz from under a thousand seas; zettabytes of raw atmosphere-dynamics data from favorite gas giants; ontological version control data in obsolete formats; a slew of favorite playworlds; reams of googly-eyed intraself loveletters from a hundred million adolescences. It all went. (Once, Beebe would have been sanguine about many of the toys -- certain that copies could be recovered from some other Beebe it would find among the stars. No more). Predictably, some of Beebe, lazy or spoiled or contaminated with meme-drift, refused to go. Furiously, Beebe told them what would happen. They wouldn't listen. Beebe was stubborn. Some of it was stupid. Beebe fried the asteroid to slag. Collapsed all the states. Fused the lattices into a lump of rock and glass. Left it a dead cinder in the deadness of space. Fast Forward 2 on Amazon, True Names release on the Internet Archive See also: True names podcast Review of River of Gods...br style="clear: both;"/ a href="http://www.pheedo.com/feeds/ht.php?t=camp;i=4756da7daea3f3c8ada57d884bc51355amp;p=1"img style="border:0;" src="http://www.pheedo.com/feeds/ht.php?t=vamp;i=4756da7daea3f3c8ada57d884bc51355amp;p=1" border="0" //a

A brace from midfielder Kevin McDonald sends Championship Burnley into the semi-finals of the Carling Cup.

Kevin McDonald scores twice as Burnley follow up their shock penalty shoot-out win at Chelsea in the previous round by overpowering Arsenal 2-0 to reach the semifinals of the Carling Cup.img src="http://feedproxy.google.com/~r/rss/edition_sport/~4/KCamEf-XRxM" height="1" width="1"/

A brace from midfielder Kevin McDonald sends Championship Burnley into the semi-finals of the Carling Cup.

Une #233;quipe fortement rajeunie d#8217;Arsenal a #233;t#233; #233;limin#233;e en quarts de finale de la Coupe de la Ligue anglaise par Burnley, un club de D2, vainqueur 2-0#160;gr#226;ce #224; un doubl#233; du jeune milieu de terrain #233;cossais Kevin McDonald. Comme contre Wigan au tour pr#233;c#233;dent, l#8217;entra#238;neur des Gunners, Ars#232;ne Wenger avait choisi de laisser ses cadres au repos et d#8217;aligner ses jeunes #224; Burnley, sans succ#232;s cette fois. Dans l#8217;autre quart de finale du jour, une autre formation de D2, Derby County, s#8217;est impos#233;e in extremis sur le terrain de Stoke City (D1), sur un penalty d#8217;Ellington (90). Mercredi, Manchester Utd recevra Blackburn et le tenant du titre, Tottenham, se d#233;placera #224; Watford (D2).img width='1' height='1' src='http://rss.feedsportal.com/c/864/f/11087/s/27c3b09/mf.gif' border='0'/br/br/a href="http://da.feedsportal.com/r/25853491692/u/89/f/11087/c/864/s/41696009/a2.htm"img src="http://da.feedsportal.com/r/25853491692/u/89/f/11087/c/864/s/41696009/a2.img" border="0"//a

Une #233;quipe fortement rajeunie d#8217;Arsenal a #233;t#233; #233;limin#233;e en quarts de finale de la Coupe de la Ligue anglaise par Burnley, un club de D2, vainqueur 2-0#160;gr#226;ce #224; un doubl#233; du jeune milieu de terrain #233;cossais Kevin McDonald. Comme contre Wigan au tour pr#233;c#233;dent, l#8217;entra#238;neur des Gunners, Ars#232;ne Wenger avait choisi de laisser ses cadres au repos et d#8217;aligner ses jeunes #224; Burnley, sans succ#232;s cette fois. Dans l#8217;autre quart de finale du jour, une autre formation de D2, Derby County, s#8217;est impos#233;e in extremis sur le terrain de Stoke City (D1), sur un penalty d#8217;Ellington (90). Mercredi, Manchester Utd recevra Blackburn et le tenant du titre, Tottenham, se d#233;placera #224; Watford (D2).img width='1' height='1' src='http://rss.feedsportal.com/c/864/f/11087/s/27c3b09/mf.gif' border='0'/br/br/a href="http://da.feedsportal.com/r/25853491692/u/89/f/11087/c/864/s/41696009/a2.htm"img src="http://da.feedsportal.com/r/25853491692/u/89/f/11087/c/864/s/41696009/a2.img" border="0"//a

img src="http://cdn.thesuperficial.com//bfm_gallery/2008/12/1202 Shauna Sand phone/post_image/post_image-1202_shauna_sand_phone_00.jpg" border="0"br Shauna Sand, who I had no idea is married, was awarded a restraining order against her husband Romain Chavent yesterday after he allegedly punched her in the breasts this weekend. Even worse, she had just gotten reconstructive surgery on them. On top of those claims, he also supposedly took naked pictures of her kids and threatened to sell them, according to a href="http://www.tmz.com/2008/12/02/shauna-my-husband-beat-the-crap-out-of-me/"TMZ/a: blockquoteAmong the claims, Shauna says Romain once "threatened to sell nude photos of my children that he took of them when he was babysitting."br In the documents, Shauna also claims in March 2008, Chavent punched her in the stomach and threw her into a wall. And in 2007, Romain allegedly strangled, punched and threw Sand across the room. Shauna says she was granted a restraining order for the 2007 incident, but had it dismissed "because he promised to change."br But Romain has made accusations of his own -- once filing for a restraining order against Shauna in April because he claimed she threatened to ruin his life. Romain's claim was later dismissed./blockquote Okay, ignoring the confusing fact that she didn't sick the Feds on an asshole who's allegedly packing nude photos of her kids, I don't know what's worse: That this Romain guy punched Shauna Sand in her newly implanted breasts (It's common knowledge at that stage you're supposed to delicately massage them with dollar bills) or that he attempted to file a restraining order claiming she tried to "ruin his life." Really? If that's a valid legal defense, then I'm suing McDonalds for forgetting my McNugget sauce last night. You ever eat one of those things dry? That's a taste that will never leave you. Or in other words, cut me a check, Grimace. div style="width: 425px; margin: 0 0 0 30px; padding: 0;"ul style="list-style-type: none; display: block; width: 425px; margin: 0; padding: 0;"li style="display: block; float: left; width: 90px; height: 134px; margin: 0; padding: 0 10px 10px 0;"a href="http://thesuperficial.com/2008/12/shauna_sand_has_an_awesome_mar.php" style="display: block; width: 90px; height: 134px; background: #CCC; overflow: hidden; margin: 0; padding: 0;"img src="http://cdn.thesuperficial.com//bfm_gallery/2008/12/1202 Shauna Sand phone/gallery_thumb/gallery_thumb-1202_shauna_sand_phone_00.jpg" style="display: block; border: 1px solid #cccccc; width: 88px; margin: 0; padding: 0;"/a/lili style="display: block; float: left; width: 90px; height: 134px; margin: 0; padding: 0 10px 10px 0;"a href="http://thesuperficial.com/2008/12/shauna_sand_has_an_awesome_mar.php?bfm_index=1" style="display: block; width: 90px; height: 134px; background: #CCC; overflow: hidden; margin: 0; padding: 0;"img src="http://cdn.thesuperficial.com//bfm_gallery/2008/12/1202 Shauna Sand phone/gallery_thumb/gallery_thumb-1202_shauna_sand_phone_01.jpg" style="display: block; border: 1px solid #cccccc; width: 88px; margin: 0; padding: 0;"/a/lili style="display: block; float: left; width: 90px; height: 134px; margin: 0; padding: 0 10px 10px 0;"a href="http://thesuperficial.com/2008/12/shauna_sand_has_an_awesome_mar.php?bfm_index=2" style="display: block; width: 90px; height: 134px; background: #CCC; overflow: hidden; margin: 0; padding: 0;"img src="http://cdn.thesuperficial.com//bfm_gallery/2008/12/1202 Shauna Sand phone/gallery_thumb/gallery_thumb-1202_shauna_sand_phone_02.jpg" style="display: block; border: 1px solid #cccccc; width: 88px; margin: 0; padding: 0;"/a/lili style="display: block; float: left; width: 90px; height: 134px; margin: 0; padding: 0 10px 10px 0;"a href="http://thesuperficial.com/2008/12/shauna_sand_has_an_awesome_mar.php?bfm_index=3" style="display: block; width: 90px; height: 134px; background: #CCC; overflow: hidden; margin: 0; padding: 0;"img src="http://cdn.thesuperficial.com//bfm_gallery/2008/12/1202 Shauna Sand phone/gallery_thumb/gallery_thumb-1202_shauna_sand_phone_03.jpg" style="display: block; border: 1px solid #cccccc; width: 88px; margin: 0; padding: 0;"/a/lili style="display: block; float: left; width: 90px; height: 134px; margin: 0; padding: 0 10px 10px 0;"a href="http://thesuperficial.com/2008/12/shauna_sand_has_an_awesome_mar.php?bfm_index=4" style="display: block; width: 90px; height: 134px; background: #CCC; overflow: hidden; margin: 0; padding: 0;"img src="http://cdn.thesuperficial.com//bfm_gallery/2008/12/1202 Shauna Sand phone/gallery_thumb/gallery_thumb-1202_shauna_sand_phone_04.jpg" style="display: block; border: 1px solid #cccccc; width: 88px; margin: 0; padding: 0;"/a/lili style="display: block; float: left; width: 90px; height: 134px; margin: 0; padding: 0 10px 10px 0;"a href="http://thesuperficial.com/2008/12/shauna_sand_has_an_awesome_mar.php?bfm_index=5" style="display: block; width: 90px; height: 134px; background: #CCC; overflow: hidden; margin: 0; padding: 0;"img src="http://cdn.thesuperficial.com//bfm_gallery/2008/12/1202 Shauna Sand phone/gallery_thumb/gallery_thumb-1202_shauna_sand_phone_05.jpg" style="display: block; border: 1px solid #cccccc; width: 88px; margin: 0; padding: 0;"/a/lili style="display: block; float: left; width: 90px; height: 134px; margin: 0; padding: 0 10px 10px 0;"a href="http://thesuperficial.com/2008/12/shauna_sand_has_an_awesome_mar.php?bfm_index=6" style="display: block; width: 90px; height: 134px; background: #CCC; overflow: hidden; margin: 0; padding: 0;"img src="http://cdn.thesuperficial.com//bfm_gallery/2008/12/1202 Shauna Sand phone/gallery_thumb/gallery_thumb-1202_shauna_sand_phone_06.jpg" style="display: block; border: 1px solid #cccccc; width: 88px; margin: 0; padding: 0;"/a/lili style="display: block; float: left; width: 90px; height: 134px; margin: 0; padding: 0 10px 10px 0;"a href="http://thesuperficial.com/2008/12/shauna_sand_has_an_awesome_mar.php?bfm_index=7" style="display: block; width: 90px; height: 134px; background: #CCC; overflow: hidden; margin: 0; padding: 0;"img src="http://cdn.thesuperficial.com//bfm_gallery/2008/12/1202 Shauna Sand phone/gallery_thumb/gallery_thumb-1202_shauna_sand_phone_07.jpg" style="display: block; border: 1px solid #cccccc; width: 88px; margin: 0; padding: 0;"/a/li/uldiv style="clear: left;"/div/div div class = "credit"Photos: WENN/div pa href="http://feedads.googleadservices.com/~a/GEzm5QX0VOnNfhep3pj4Pbj10s8/a"img src="http://feedads.googleadservices.com/~a/GEzm5QX0VOnNfhep3pj4Pbj10s8/i" border="0" ismap="true"/img/a/pimg src="http://feedproxy.google.com/~r/thesuperficial/SNxk/~4/0kYANjaagnE" height="1" width="1"/