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Auteur : AKRAM777
Tags : akram 777 bentley gt vendetta drift ferrari police poursuite phantom gta audi R8 S8 disco 4 vitesse amg mercedes guns r8 and roses clk porsche amusant circuit voiture paris 2008 burn danger amv
Envoyé : 04 décembre 2008
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Publication Date: 2008 Nov 18 PMID: 19041877br/Authors: Chang, E. S. - Liao, T. Y. - Lim, T. S. - Fann, W. - Chen, R. P.br/Journal: J Mol Biolbr/br/Amyloid plaques, formed from amyloid beta (Abeta) peptides (mainly Abeta40 or Abeta42), are one of the most important pathological characteristics of Alzheimer's disease. Here, a single D-form proline substitution in the 40-amino-acid Abeta40 peptide can totally change the aggregation behavior of this peptide. The residue immediately preceding each glycine in Abeta40 (S8, V24, I32, and V36) was individually replaced by D-form proline ((D)Pro). The resulting (D)P-G sequence (the (D)Pro residue and the following Gly residue) was designed as a structural clip to force the formation of a bend in the peptide, as this sequence has been reported to be a strong promoter of beta-hairpin formation. The mutant peptide with Val24-to-(D)Pro substitution, named V24P, formed a new amyloid-like beta-aggregate at high peptide concentration. The aggregate has most of the characteristics of amyloid fibrils, except fibril morphology. Moreover, the mutant peptide V24P, when mixed with Abeta40, can attenuate the cytotoxicity of Abeta40.br/br/post to: a href = http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D19041877title=Entrez+PubmedCiteULike/a

Olivier Besancenot à fond dans Paris avec son Audi S8.