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BMC Bioinformatics -
16 hours and 23 minutes ago
Publication Date: 2010 Mar 18 PMID: 20298595Authors: Shen, Z. - Qu, W. - Wang, W. - Lu, Y. - Wu, Y.
- Li, Z. - Hang, X. - Wang, X. - Zhao, D. - Zhang, C.Journal: BMC BioinformaticsABSTRACT:
BACKGROUND: Multiplex PCR, defined as the simultaneous amplification of multiple regions of a DNA
template or multiple DNA templates using more than one primer set (comprising a forward primer and
a reverse primer) in one tube, has been widely used in diagnostic applications of clinical and
environmental microbiology studies. However, primer design for multiplex PCR is still a challenging
problem and several factors need to be considered. These problems include mis-priming due to
nonspecific binding to non-target DNA templates, primer dimerization, and the inability to separate
and purify DNA amplicons with similar electrophoretic mobility. RESULTS: A program named MPprimer
was developed to help users for reliable multiplex PCR primer design. It employs the widely used
primer design program Primer3 and the primer specificity evaluation program MFEprimer to design and
evaluate the candidate primers based on genomic or transcript DNA database, followed by careful
examination to avoid primer dimerization. The graph-expanding algorithm derived from the greedy
algorithm was used to determine the optimal primer set combinations (PSCs) for multiplex PCR assay.
In addition, MPprimer provides a virtual electrophotogram to help users choose the best PSC. The
experimental validation from 2x to 5x plex PCR demonstrates the reliability of MPprimer. As another
example, MPprimer is able to design the multiplex PCR primers for DMD (dystrophin gene which caused
Duchenne Muscular Dystrophy), which has 79 exons, for 20x, 20x, 20x, 14x, and 5x plex PCR reactions
in five tubes to detect underlying exon deletions. CONCLUSIONS: MPprimer is a valuable tool for
designing specific, non-dimerizing primer set combinations with constrained amplicons size for
multiplex PCR assays.post to:
CiteULike

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CiteULike: Borelli's watchlist -
19 hours and 9 minutes ago
Pharmacological Reviews, Vol. 53, No. 1. (1 March 2001), pp. 1-24.
G protein-coupled receptors (GPCRs) are seven transmembrane proteins that form the largest single
family of integral membrane receptors. GPCRs transduce information provided by extracellular
stimuli into intracellular second messengers via their coupling to heterotrimeric G proteins and
the subsequent regulation of a diverse variety of effector systems. Agonist activation of GPCRs
also initiates processes that are involved in the feedback desensitization of GPCR responsiveness,
the internalization of GPCRs, and the coupling of GPCRs to heterotrimeric G protein-independent
signal transduction pathways. GPCR desensitization occurs as a consequence of G protein uncoupling
in response to phosphorylation by both second messenger-dependent protein kinases and G
protein-coupled receptor kinases (GRKs). GRK-mediated receptor phosphorylation promotes the binding
of β-arrestins, which not only uncouple receptors from heterotrimeric G proteins but
also target many GPCRs for internalization in clathrin-coated vesicles.
β-Arrestin-dependent endocytosis of GPCRs involves the direct interaction of the
carboxyl-terminal tail domain of β-arrestins with both β-adaptin and
clathrin. The focus of this review is the current and evolving understanding of the contribution of
GRKs, β-arrestins, and endocytosis to GPCR-specific patterns of desensitization and
resensitization. In addition to their role as GPCR-specific endocytic adaptor proteins,
β-arrestins also serve as molecular scaffolds that foster the formation of alternative,
heterotrimeric G protein-independent signal transduction complexes. Similar to what is observed for
GPCR desensitization and resensitization, β-arrestin-dependent GPCR internalization is
involved in the intracellular compartmentalization of these protein complexes.
Stephen Ferguson

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BMC Bioinformatics -
19 hours and 23 minutes ago
Publication Date: 2010 Mar 18 PMID: 20298548Authors: Maraziotis, I. A. - Dragomir, A. - Thanos,
D.Journal: BMC BioinformaticsABSTRACT: BACKGROUND: Inference of gene regulatory networks is a key
goal in the quest for understanding fundamental cellular processes and revealing underlying
relations among genes. With the availability of gene expression data, computational methods aiming
at regulatory networks reconstruction are facing challenges posed by the data's high
dimensionality, temporal dynamics or measurement noise. We propose an approach based on a novel
multi-layer evolutionary trained neuro-fuzzy recurrent network (ENFRN) that is able to select
potential regulators of target genes and describe their regulation type. RESULTS: The recurrent,
self-organizing structure and evolutionary training of our network yield an optimized pool of
regulatory relations, while its fuzzy nature avoids noise-related problems. Furthermore, we are
able to assign scores for each regulation, highlighting the confidence in the retrieved relations.
The approach was tested by applying it to several benchmark datasets of yeast, managing to acquire
biologically validated relations among genes. CONCLUSIONS: The results demonstrate the
effectiveness of the ENFRN in retrieving biologically valid regulatory relations and providing
meaningful insights for better understanding the dynamics of gene regulatory networks. The
algorithms and methods described in this paper have been implemented in a Matlab toolbox and are
available from: http://bioserver-1.bioacademy.gr/DataRepository/Project_ENFRN_GRN/.post to:
CiteULike

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MacUpdate - Mac OS X -
21 hours and 54 minutes ago
NVIDIA CUDA 3.0 NVIDIA CUDA is a C language development environment for
CUDA-enabled GPUs. The CUDA development environment includes:
- nvcc C compiler
- CUDA FFT and BLAS libraries for the GPU
- Profiler
- gdb debugger for the GPU (alpha available in March, 2008)
- CUDA runtime driver (now also available in the standard NVIDIA GPU driver)
- CUDA programming manual
The CUDA Developer SDK provides examples with source code to help you get started with CUDA.
Examples include:
- Parallel bitonic sort
- Matrix multiplication
- Matrix transpose
- Performance profiling using timers
- Parallel prefix sum (scan) of large arrays
- Image convolution
- 1D DWT using Haar wavelet
- Many more features
WHAT'S NEWVersion 3.0:
Release Highlights
- Support for the new Fermi architecture, with:
-
- Native 64-bit GPU support
- Multiple Copy Engine support
- ECC reporting
- Concurrent Kernel Execution
- Fermi HW debugging support in cuda-gdb
- Fermi HW profiling support for CUDA C and OpenCL in Visual Profiler
- C++ Class Inheritance and Template Inheritance support for increased programmer productivity
- A new unified interoperability API for Direct3D and OpenGL, with support for:
-
- OpenGL texture interop
- Direct3D 11 interop support
- CUDA Driver / Runtime Buffer Interoperability, which allows applications using the CUDA
Driver API to also use libraries implemented using the CUDA C Runtime such as CUFFT and CUBLAS.
- CUBLAS now supports all BLAS1, 2, and 3 routines including those for single and double
precision complex numbers
- Up to 100x performance improvement while debugging applications with cuda-gdb
- cuda-gdb hardware debugging support for applications that use the CUDA Driver API
- cuda-gdb support for JIT-compiled kernels
- New CUDA Memory Checker reports misalignment and out of bounds errors, available as a
stand-alone utility and debugging mode within cuda-gdb
- CUDA Toolkit libraries are now versioned, enabling applications to require a specific
version, support multiple versions explicitly, etc.
- CUDA C/C++ kernels are now compiled to standard ELF format
- Support for device emulation mode has been packaged in a separate version of the CUDA C
Runtime (CUDART), and is deprecated in this release. Now that more sophisticated hardware
debugging tools are available and more are on the way, NVIDIA will be focusing on supporting
these tools instead of the legacy device emulation functionality.
-
- On Windows, use the new Parallel Nsight development environment for Visual Studio, with
integrated GPU debugging and profiling tools (was code-named "Nexus"). Please see www.nvidia.com/nsight for details.
- On Linux, use cuda-gdb and cuda-memcheck, and check out the solutions from Allinea and
TotalView that will be available soon.
- Support for all the OpenCL features in the latest R195 production driver package:
-
- Double Precision
- Graphics Interoperability with OpenCL, Direc3D9, Direct3D10, and Direct3D11 for high
performance visualization
- o Query for Compute Capability, so you can target optimizations for GPU architectures
(cl_nv_device_attribute_query)
- Ability to control compiler optimization settings via support for pragma unroll in OpenCL
kernels and an extension that allows programmers to set compiler flags.
(cl_nv_compiler_options)
- OpenCL Images support, for better/faster image filtering
- 32-bit global and local atomics for fast, convenient data manipulation
- Byte Addressable Stores, for faster video/image processing and compression algorithms
- Support for the latest OpenCL spec revision 1.0.48 and latest official Khronos OpenCL
headers as of 2010-02-17
REQUIREMENTSMac OS X 10.6 or later.
PRICEFree
DEVELOPER NVIDIA
Corporation
DOWNLOADS2744
DOWNLOAD NOW
(51.8 MB)
More information

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Guardian Unlimited -
22 hours and 2 minutes ago
The favourite new drug of clubbers and schoolchildren hit the headlines last week when two young
men died after taking it. Sold under a range of street names – meph, miaow
miaow, MC, drone and bubbles – and easily available on the web, mephedrone is
not illegal. But should it be? Here, four people from different sides of the debate
– a user, a mother, a dealer and a doctor – have their say
on 'the poor man's cocaine'
The user: Jack Starks
The first time I encountered mephedrone, meow meow, plant food or whatever you want to call it,
was about a year ago at a friend's house in south London. We were back from a night out at the
student union and all wanting to continue the party when my friend's flatmate, Brandon, got back
from work and, with a sly smile, disappeared into his bedroom, to return with a huge box. He
dumped the biggest pile of powder I had ever seen on the table. "This, my friends, is
mephedrone," he said with relish. "And this is the future."
Like many students, I've never been one to say no to a new experience. We all end up running into
drugs at some point, so I decided to see what all the fuss was about. I've always enjoyed a
spliff and, on occasion, a little more, so I assumed this was just another casual substance I
would be bumping into.
Nicknamed by users as "poor man's cocaine", mephedrone has swept through our nation's youth like
a strong dose of salts, permeating every aspect of the party and night club scene. In less than
six months, it has come from obscurity; everyone knows someone who's on it. Paradoxically, it was
given a chance to become popular because of an EU restriction that prevented the importation of
two substances necessary to the production of MDMA (ecstasy to the layman) that made it
impossible to make or purchase any MDMA in Britain from late 2008. Mephedrone filled the gap in
the market, and at half the cost of MDMA; it was everywhere.
You can snort it, drop it in "bombs" (rolling papers filled with it), and I've even come across
people who eat it. The effect is euphoric, in some ways similar to ecstasy but much
shorter-lived; you need to take a lot more of it a lot more often. The first time I took it, I
could feel my heart pounding; everything seemed as if it was about to explode into life and I was
up till the early hours in a wild rampage of excitement. But there any comparison ends. With
mephedrone, the romance period is very short: after taking it just a couple of times, your
tolerance increases dramatically, to the point that you're doing three or four times more than
you were in the beginning to get high. Your appetite for the stuff also increases.
Brandon was well ahead of the curve. He was importing it from China at about a £1 a gram
and selling it to students at £15. By mid-October, when our student loans had still failed
to appear and finance was getting tight, we hit on the idea of doing the same. We could simply
make a trip down to a seedy office in Victoria where we could buy it in bulk at wholesale price
and then sell it on to our friends at a profit. Doing this you could turn £100 into
£400 in a weekend and have a bit left on the side for yourself.
It became a crash course in drug dealing for beginners, and we weren't the only ones at it.
Hundreds of students had spotted the gap in the market. You couldn't set foot in a club or
house-party without someone walking past offering you "drone".
Whether or not this was legal is a good question, because although mephedrone isn't covered by
the Misuse of Drugs Act, it is illegal to sell it for human consumption. Companies get round this
by putting stickers on their product saying just that. When selling it, we would always tell
people that it was not to be used to get high – it was almost a running joke.
A very dangerous joke indeed.
When on it, you get very edgy (hence the comparison to cocaine) and you constantly crave more. It
is possibly the most addictive substance I have ever come across. What makes it far more
dangerous is that it is the first of a new breed of designer drugs, made purely to evade the laws
surrounding controlled substances.
No one has considered what this will do to people in the short or the long term, and no one
cares. Mephedrone might be called "plant food", but it is a plant decomposer, so what it does to
your insides I dread to think. I once accidentally left a spoon in a bag of the stuff and came
back three days later to find it had stripped off the outer coating and my mephedrone scattered
with tiny silver bits of spoon. We still snorted it.
My stance was changed dramatically by my experience of prolonged use. After three or so months of
using it at least a couple of times a week, I found myself in the darkest depression. I stopped
taking it and suddenly found myself looking round at my friends with their eyes rolling in their
heads and realised how much rubbish we had all been talking to each other. Good, straight-edge
kids who barely used to drink have become crazed drug fiends, sitting in their house snorting
plant food five days a week.
One friend of mine took it once and now has to use an inhaler, because he has permanently damaged
his lungs. Another has almost ceased to be a friend, and is now a socially apathetic zombie,
chasing mephedrone around London with his girlfriend, no longer able to interact without it,
constantly asking if he can borrow 20 quid.
We've always been happy to get wasted on a night out, but I've never seen anything creep into so
many everyday lives like this. I am horrified by the effect this drug has had on the people
around me, and would urge anyone thinking about taking some tonight to change their plans.
Jack Starks is a student in his early 20s who lives in south London
The mother: Sophie Radice
For all those parents who have read with sadness about the deaths of an 18-year-old and a
19-year-old in Scunthorpe, but allowed themselves to be even slightly reassured that their own
teenagers can't have come across mephedrone because they are so much younger, not yet clubbing
and living very different lives, think again.
I first heard about mephedrone six months ago, at first from another north London mother whose
son had ordered this "plant food" off the internet and who had roused her suspicions when he
couldn't explain why he had suddenly developed an interest in gardening.
Then from my own daughter, aged 14 at the time, whose friends had discovered this legal high. She
described them as "talking rubbish as if it is the most interesting thing in the world, and that
they dribble and lick their lips and gurn and grind their teeth".
She said that people shook, bit holes in their lips and cheeks, were unable to feel their legs,
were frightened because their heart was beating too fast and that their skin looked grey.
This might seem like any teenage group that has discovered harder drugs. It is rather like a
description of my own group of friends at that age. What is different is that, in those six
months, those friends who thought they were just experimenting seemed to need to take greater
amounts of mephedrone on more and more occasions. Mephedrone is often sold in five gram bags and,
as it is so "more-ish", it seems to be easy – even common –
for a user to go through a whole bag.
Surely that kind of ever-decreasing, short-lived high is what makes dealers extremely rich and
leads to the kind of desperate endless addiction of the crack-user?
Should all of this mean that we should immediately ban it? Well, I have always had a liberal view
about drugs, believing that the criminalisation of drugs just creates an underground. I look at
how making ketamine (a horse tranquilliser) a class C drug didn't stop its use among the young.
On an intellectual level, I agree with Professor David Nutt's measured suggestion of creating a
"holding" class of D drug category. Within this category, sales would be limited to over-18s; the
product would be quality-controlled, at doses limited as far as possible to safe levels; and it
would come with health education messages. I also agree with Nutt that what we should look into
is why teenagers are so drawn to taking drugs and why binge-drinking is so prevalent in this age
group.
On a much more visceral, instinctive level, this "let's wait and see how harmful this drug is" D
category doesn't comfort me at all. For this younger age group, the legality of mephedrone is a
real attraction. While they can get hold of "weed" to smoke (mostly through older siblings, and
even parents), because they are not yet going to clubs but to each other's houses or private
parties they are rarely able to get their hands on harder drugs.
They can buy mephedrone off the internet or from headshops (shops selling drug paraphernalia) or
stalls. Teenagers of this age seem to think that its legality means that it is safer than other
drugs, which might also contribute to the wild abandon with which it is taken.
Health warnings wouldn't do a thing (my daughter says that, perversely, the deaths in Scunthorpe
have made her friends even more determined to take the drug) and surely an over-18s rule on the
net would be just like those porn sites that ask you to click a button to say that you are over
18 and that's all the proof you need. Prosecution of those selling to under-18s would be almost
impossible in cases of website dealing.
For this age group, making mephedrone a class B drug would at least put up some sort of
substantial hurdle and make it much harder for them to get hold of.
Just making it so much more difficult to track down may cause enough of a pause for some sort of
easing-off from the enthusiastic consumption of what seems to be a particularly addictive drug.
Oh, and while we are waiting for a decision on this, look out for a fishy smell in your
teenager's sweat, nose bleeds, restlessness, headaches, insomnia and a traces of yellowy powder
on the surfaces in their room.
Sophie Radice is a journalist and mother of two who first came across the drug last year
The dealer: Mark
I have no background in narcotics. My worst offence is a puff on a joint in college, which I
found unpleasant. I am at heart "anti" substance abuse, though I am in favour of free choice.
I own and run three normal, legitimate businesses, all of which, thanks to the recession, have
had their troubles. Have you ever laid off a loyal member of staff? It's the worst feeling in the
world. I was looking for a lifeline.
I first heard of mephedrone in September. A friend heard about a new chemical that was originally
a kind of plant food. It was legal and its effects mimicked cocaine and MDMA. I started searching
for information on Google and within an hour I knew this would be a winning business.
From the start, I wanted to run this completely legitimately. No shady cash deals, pay tax, give
excellent service with a quality product at the right price. Was I comfortable with the concept?
No. Did I want to lose my home to the bank? No. Decision made.
In the first weeks, I bought my stock inside the UK, but very quickly I began buying direct from
a manufacturer in China. I registered a company and contacted a web designer.
This is where the problems started. Even before the press discovered mephedrone, it was not
possible to find good professional help. Undaunted, I built my own website. No banks would touch
the credit card side of the business. I fudged round this and I was up and running. I launched
the website and within an hour had five sales. My first week I turned over £8,000; the
second, £10,000.
Then, last November, mephedrone hit the headlines. Its use was blamed for the death of a
14-year-old girl, although this turned out not to be the case. I thought it was the end. How
wrong I was. That week, sales doubled. When mephedrone is in the news, demand rockets. Last week
came the death of two boys. (I cannot comment on this tragedy, except to say I do not believe
mephedrone was the cause.) One of my websites, which usually gets around 1,200 hits a day,
received more than 20,000. The media have made mephedrone what it is.
Before you leap to judgment, do you drink alcohol? It is deadly, with 8,000 deaths directly
attributed to it in the UK in 2008. There is a huge trade in illegal drugs in the UK. But people
do not have to be criminals. They don't have to buy bags of drain cleaner from dodgy blokes in
pub car parks.
The process of importing has become difficult lately, as UK Customs has begun withholding
shipments. I have had 40kg seized. No explanation has been given and Customs has made no contact.
This is surely illegal.
Mephedrone looks likely to be banned. This is the most dangerous thing that can happen. It is
essentially a very safe substance. There is no addiction and to date I know of no deaths directly
attributed to it. There are suppliers online such as me who treat this as a genuine business and
supply a quality product pure to the customer.
The day mephedrone is banned, I will shut up shop. The taxman will lose hundreds of thousands of
pounds and the criminals will step in. Prohibition has always failed. And the genie is really out
of the bottle this time. Millions have used mephedrone in the UK. If they are stopped from
getting it legally, they will either buy illegally or, even worse, try something new.
No British government would have the courage to exercise the level of common sense needed to keep
it legal, what with an election looming and swarms of horrified Daily Mail readers to
impress. This government has already sacked the moderate, sensible and knowledgeable Dr David
Nutt. Mephedrone will be banned – and be dammed.
Mark is a businessman and owner of several websites that sell mephedrone
The doctor: James Bell
I first heard about mephedrone last July. The young man sitting opposite me told me that it had
just arrived on the nightclub scene. He had tried it at once. He was well-educated and from a
prosperous and stable family (who knew nothing about his drug use). He was in my clinic to
withdraw from another "legal high", GBL. After using GBL for a few months, he had been dismayed
to discover that he had become dependent. His lament "I didn't know it was addictive" could have
been uttered by most doctors and policy-makers.
We are all playing catch-up as new compounds are recognised, banned – and new
drugs appear, the risks of which slowly become apparent. Legal highs are mostly compounds closely
related to known (and banned) psychoactive drugs. Mephedrone is chemically very similar to
ecstasy. The slight variation in structure makes it legal, but also means that mephedrone has
different pharmacological effects and toxicity.
This makes difficulty for the advisory council on the misuse of drugs, which advises the
government on whether a drug should be banned, as it has little information to go on. It takes
experience to find out about the harms of particular drugs. It was only in the late 1990s, after
years in which cannabis was regarded as a fairly harmless drug, that studies demonstrated it
caused the development of psychosis in some vulnerable adolescents. News that two people died
after using mephedrone suggests it may be dangerous, but we don't know enough. Mephedrone can
cause cardiovascular problems, but I suspect that the post-mortem findings will identify other
contributing drugs.
GBL, which was classified in December 2009, is a case study in legal highs. Many users overdose
inadvertently and a small proportion progress to dependence. On trying to stop, users can
experience severe withdrawal symptoms. Throughout 2009, most GPs and drug services knew nothing
of GBL, and were unable to offer treatment. It was to catch up with this need that a "party
drugs" clinic was established in south London . Attendees have reported that, since being banned,
GBL is still readily available for same-day delivery, from internet sites outside the UK.
Mephedrone and GBL both enhance confidence and sociability and reduce sexual inhibitions.
However, it is easy to lose the plot. The first dose of mephedrone produces intense euphoria, but
repeated dosing produces decreasing pleasure and increasing paranoia and irritability
– yet some people keep chasing the initial high until exhausted. This binge
pattern of use maximises risks and minimises benefits of drug use.
A pre-election environment is a bad time to initiate a discussion about drugs policy, as there is
a risk that any debate will degenerate into which party is going to ban more drugs, more rapidly.
"Legal highs" are an easy target for moral outrage, precisely because they are legal and
something can be done about that. More difficult is trying to address Britain's prodigious demand
for drugs, legal and illegal. A non-partisan debate about reducing the harm would be valuable.
Dr James Bell is an addictions consultant at the South London and Maudsley NHS Trust
guardian.co.uk © Guardian News & Media
Limited 2010 | Use of this content is subject to our Terms & Conditions | More Feeds

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Guardian Unlimited -
22 hours and 2 minutes ago
Alistair Darling will announce plans to back low-carbon transport and energy projects in 'budget
for growth'
Alistair Darling will this week announce a £1bn fund to kick-start investment in green
transport and energy projects as part of a "budget for growth".
With Wednesday's budget coming weeks before an expected general election, the chancellor will use
his plans for the new low-carbon infrastructure scheme to contrast Labour's support for industry
with the Conservatives' more hands-off philosophy.
Business secretary Lord Mandelson, who has spearheaded the government's new, more interventionist
approach, told the Observer that the Conservatives "wouldn't lift a single finger" to
help manufacturing.
With the public finances tight, the new green fund will be relatively small in scale, but the
government hopes to use the cash to tempt private investors to back innovative new ideas. "It's
about saying there are ways in which the government can play a role, which are not necessarily
multibillion-pound projects," said a Treasury source. He cited the model of the Sheffield
Forgemasters plant, where Mandelson last week used an £80m loan from taxpayers to secure a
£170m financing package that included support from the European Investment Bank and nuclear
supplier Westinghouse.
The Sheffield Forgemasters deal – which will create 180 jobs initially and
provide 1,000 apprenticeships – was one of several new industrial investments
announced in recent weeks that have been secured with the help of public subsidy.
Mandelson said: "People say: why am I securing Vauxhall, why am I securing the Nissan electric
car to be produced in Sunderland, why am I securing the development and production of Ford's
green technologies, why did I go to Sheffield Forgemasters to deliver funding for a 15,000-tonne
press? It's because if the government doesn't act here, some other government will. If we hadn't
bridged the final mile in the way that we did, because the market couldn't or wouldn't provide,
then the investment would have gone elsewhere."
With the government committed to reduce UK carbon emissions by 80% by 2050, radical changes in
infrastructure and power generation will be needed over the coming decades. Labour hopes that by
boosting low-carbon energy such as wind, wave and solar power, and helping to upgrade the
transport system to use cleaner fuels, it can help to meet those targets while creating thousands
of new "green-collar jobs".
But environmental campaigners warned that £1bn would not go very far. Andrew Simms,
director of the New Economics Foundation, said: "If what they're talking about is less than one
five-hundredth of the amount that was thrown at the banking system, at a point where investment
banks have bonus pots bigger than £1bn, then while the idea is right, the size of the
ambition smacks of skewed priorities."
Comparing the task of preparing for a new low-carbon era to the long drive from London to
Edinburgh, he said: "You won't get very far on a teacupful of petrol." The Stern review on the
economics of climate change suggested it would cost more than £10bn a year to prepare the
economy for cuts in emissions on the scale needed.
Mandelson stressed that as well as underpinning growth, the budget would also reaffirm Labour's
determination to tackle the public deficit. The latest official figures showed that the public
finances are in a healthier state than the chancellor feared at the time of December's pre-budget
report, and he could reduce his £178bn estimate of this year's deficit by as much as
£10bn.
But Mandelson said that would not alter the government's plans for tax rises and public spending
cuts in the years ahead. "We will maintain a tough deficit reduction programme: there's no
question about it. It's necessary for the health of the economy, for the confidence of the
markets. We will make it absolutely clear that what we have committed to, we will follow
through."
However, Darling will also stress that – unlike the Conservatives, who would
start cutbacks immediately – Labour will "lock in recovery" by maintaining its
financial support for the fragile economy for another year.
The UK emerged from recession in the final quarter of 2009, growing by 0.3%, but Bank of England
policymakers have left low interest rates in place, making clear they remain nervous about the
sustainability of the upturn.
Separately, Mandelson is also likely to be given the task of overseeing a new state-backed
investment bank, which will help to support businesses struggling to secure funding from banks.
Heather Stewartguardian.co.uk © Guardian News & Media Limited 2010 | Use
of this content is subject to our Terms & Conditions | More Feeds

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Guardian Unlimited -
22 hours and 3 minutes ago
Protest groups that were targeted by infiltrators plan legal action to obtain access to police
files after disclosures by Officer A
Political activists have reacted with anger to revelations in last week's Observer that their
organisations were infiltrated by an elite undercover unit of the Metropolitan police.
Members of one of the groups demanded a public inquiry after the Observer disclosed that
a former member of Special Branch, known as Officer A, had infiltrated far-left
organisations in the mid-1990s to gather intelligence about potentially violent demonstrators. He
was regularly involved in brutal confrontations with uniformed police officers and activists from
the extreme right. On numerous occasions he engaged in violent acts to maintain his cover.
Many activists suspected they were being infiltrated by the state at the time, but it is only now
that their suspicions have been confirmed. One target of Officer A, a former student union leader
who has asked not to be identified, told the Observer: "I suspected that my phone might
have been tapped. I believed that there might have been some police spies at the demonstrations
that I attended. But however paranoid I was, I never imagined they would go so far as to invest
the level of resources needed to give someone a completely new identity for five years and have
them spy on someone like me. It really is astonishing."
Officer A was part of a secret unit of the Met known as the Special Demonstration Squad (SDS),
which since 1968 had 10 full-time undercover operatives inside so-called "subversive"
organisations to disrupt their ability to create disorder on the streets of London.
While Officer A targeted the far left, other SDS members were simultaneously infiltrating the far
right. By the end of his four-year deployment he had become a branch secretary of a leading
anti-racist organisation, Youth Against Racism in Europe (YRE). He used this position to assist
in making contact with smaller groups that had a reputation for being involved in violence.
Hannah Sell, national secretary of the YRE at the time of Officer A's deployment, remembers him
well but is furious at the implication that the group was involved in violence. "We organised
mass peaceful protests against racism and the BNP. In doing so we often faced violence from the
far right and the police."
The Observer understands that many of the tactics now used by police in public order
situations were developed in response to SDS intelligence about the best way to control potential
troublemakers. This includes the controversial tactic known as "kettling", in which protesters
are hemmed in on all sides by police, a technique many believe only heightens tensions.
Lois Austin, YRE chair at the time of Officer A's infiltration, told the Observer: "We
believe there should be a public inquiry into police tactics at demonstrations. It should be
independent, not one where the police investigate themselves. We want to know about their use of
spies and whether this unit is still operational."
The calls for an inquiry come amid fresh criticism of heavy-handed police tactics at the G20
protest in London last April, when newspaper seller Ian Tomlinson died of a heart attack soon
after being struck by a police baton and pushed to the ground. It has emerged that plainclothes
officers from City of London police mingled with the crowd to gather intelligence. Many former
activists who believe they were SDS targets intend to take legal action in an attempt to obtain
any police intelligence files about their activities.
Tony Thompsonguardian.co.uk © Guardian News & Media Limited 2010 | Use
of this content is subject to our Terms & Conditions | More Feeds

|
Guardian Unlimited -
22 hours and 3 minutes ago
Unite and Labour are in an abusive relationship that stops any chance of worthwhile change
Success hasn't spoiled Charlie Whelan. He was a character assassin and thug long before he became
famous. I last met the political director of Unite in the autumn of 2008 as he was encouraging compliant journalists to go after
Alistair Darling. I thought I had witnessed all varieties of political hypocrisy, but Whelan
still shocked me because he was attacking the chancellor for a crime that was no crime at all to
anyone in the centre-left tradition.
Darling had correctly identified that allowing speculators to run riot had left Britain facing
the worst financial crisis in 60 years. Gordon Brown had to betray a friend and denigrate an ally
for this statement of the obvious because he was the bedazzled dupe who had borrowed as if the
riotous market could roar on forever and told City bankers at the Mansion House in 2007 that
Britain needed more, rather than less, of their "vigour, ingenuity and aspiration". Despite their
loudly professed left-wing principles and equally suspect mockney accents, Whelan and Damian
McBride went for Darling for honestly admitting that boom and bust had not been abolished after
all. Lobby correspondents behaved like children egging on the playground bully, and allowed
"government sources", hiding behind the coward's cloak of anonymity, to tell their readers that
the chancellor's job was on the line.
The Thick of It does not give you the half of it. Before Darling, Whelan's
target was Martin Bright, the New Statesman's political editor. He boasted to Bright's
wife at the 2008 British Press Awards that he had the power to instruct Geoffrey Robinson, the
magazine's Brownite owner, to fire her husband and father of her children for not showing due
respect to Gordon Brown and for making a documentary about Ken Livingstone's indulgence of the
Islamist far right. "He can't allow this. He can't allow criticism of Gordon. If Geoffrey's got
any sense, he'll listen." Bright was duly forced out, although the paper insists that it remains
a part of the free press, and that its compliance with Downing Street's publicly declared wishes
was a coincidence.
I drag up these ugly scenes because the Tory attack on Whelan and Unite is missing the point.
Conservatives claim that by making Brown's spin doctor its political director, Unite is using its
powers of patronage to take over the Labour party. Unite officers are getting Labour nominations
for plum seats – John Cryer in Leyton, Jack Dromey in Birmingham Erdington – while Unite money is funding the
fight against the Tories in the marginals.
The money matters, of course, but the story isn't quite right. Manufacturing Birmingham was
always going to look favourably on Dromey, who has been involved in industrial disputes since the
1970s. Meanwhile, far from being a Whelan placeman, Cryer was another of his targets. Along with
fellow Unite officials, Cryer went on long-term sick leave after Whelan came to the union, the
cause of which may be guessed by the grievance procedures they brought against him citing stress.
Unite isn't running Labour. Both are caught in an abusive relationship, and it is hard to know
who is the abuser and who is the victim. The union is hurting Brown's cause by dragging him into
air strikes just before an election, but the union movement and British politics is suffering as
badly.
From the narrow trade unionist point of view, the BA cabin crew are not benefiting from having Whelan, the supposed master of spin, as a
comrade. The media always turn on strikers, because managers briskly deunionised most of the
industry in the 1980s, and because editors know that more readers will complain about a strike
than support it. Even if you accept that bias, you ought to be surprised that Unite is putting
its case so poorly. The public does not know that air hostesses and stewards are not
revolutionary militants, but reasonable men and women who made a conciliatory offer to accept a
pay cut instead of redundancies which extremist managers refused to countenance.
More widely, an opportunity to change the terms of public debate is being missed. Commentators
announce that the recession and strikes herald a return to the 1970s, and cannot see that today's
crisis is nothing like the collapse of social democracy a generation ago. Margaret Thatcher won
three election victories because enough voters believed that exorbitant wage demands had wrecked
the economy. This time, no one can plausibly maintain that the unions brought ruin to the
country. The folly of the financial elite, and the neglect of the public officials and
politicians who should have been regulating, brought us low in 2008. Trade unions ought to be
agitating for causes which are close to their hearts: how to create a new Britain which is not so
fatally dependent on the manipulation of money markets; how to revive manufacturing; and how to
regulate the City so that never again do working- and middle-class taxpayers have to bail out the
super-rich.
If they did, they would find that many Mail and Telegraph readers would support
them, because they know that their taxes will rise and services will be cut to pay for the City's
blunders. Yet Britain's largest union cannot begin an urgent conversation because it is not just
tying itself to Labour but to the Brownite faction, which Unite's leaders dumbly believe to be a
left-wing alternative to the hated Tony Blair. They don't understand that the Brownites are not
rough yet honourable street fighters in the Labour movement, but the Westminster equivalent of
Mafia enforcers who try to eliminate anyone who stands in their don's way regardless of their
political beliefs. They assail the chancellor for knowing a classic crisis of financial
capitalism when he sees it and journalists for criticising politicians who court religious
reactionaries. When Brown is gone, they hope to extend the Brownite reign by persuading the
unions to put the unprepossessing Ed Balls in his place, even though as Brown's deputy at the
Treasury he was as culpable for the regulatory failure as his equally unprepossessing patron.
Outsiders look at our clannish politics and ask why the Conservatives cling to Lord Ashcroft and
Labour continues to listen to Whelan when they bring nothing but disrepute to their parties. More
striking is the torpor of the trade unions, which ought to be seizing the chance to create a new
political consensus, but are letting it slip away.
Nick Cohenguardian.co.uk © Guardian News & Media Limited 2010 | Use
of this content is subject to our Terms & Conditions | More Feeds

|
Guardian Unlimited -
22 hours and 4 minutes ago
Charles Arthur investigates how the ways in which we watch sport, read magazines and do business
with each other could change for ever
Don't act too surprised if, some time in the next year, you meet someone who explains that their
business card isn't just a card; it's an augmented reality business card. You can see a collection
and, at visualcard.me, you can even design your
own, by adding a special marker to your card, which, once put in front of a webcam linked to the
internet, will show not only your contact details but also a video or sound clip. Or pretty much
anything you want.
It's not just business cards. London Fashion Week has tried them out too: little symbols that
look like barcodes printed onto shirts, which, when viewed through a webcam, come to life.
Benetton is using augmented reality for a campaign that kicked off last month, in which it is trying to find models from among the
general population.
Augmented reality – AR, as it has quickly become known –
has only recently become a phrase that trips easily off technologists' lips; yet we've been
seeing versions of it for quite some time. The idea is straightforward enough: take a real-life
scene, or (better) a video of a scene, and add some sort of explanatory data to it so that you
can better understand what's going on, or who the people in the scene are, or how to get to where
you want to go.
Sports coverage on TV has been doing it for years: slow-motion could be described as a form of
augmented reality, since it gives you the chance to examine what happened in a situation more
carefully. More recently cricket, tennis, rugby, football and golf have all started to overlay
analytic information on top of standard-speed replays – would that ball have
hit the stumps, the progress of a rally, the movement of the backs or wingers, the relative
flights of shots – to tell you more about what's going on. Probably the most
common use is in American football where the "first down" line – the distance
the team has to cover to continue its offence – is superimposed on the picture
for viewers.
But those required huge systems. AR took its first lumbering steps into the public arena eight
years ago: all that you needed to do was strap on 10kg of computing power –
laptop, camera, vision processor – and you could get an idea of what was
feasible. The American Popular Science magazine wrote about the idea in 2002 – but the idea of being permanently
connected to the internet hadn't quite jelled at that point.
"AR has been around for ages," says Andy Cameron, executive director of Fabrica, an interactive
design studio which works with Benetton, "maybe going back as far as the 1970s and art
installations that overlaid real spaces with something virtual." He mentions in particular the
work of pioneering computer artist Myron Krueger.
What's changed in the past year is that AR has come within reach of all sorts of developers
– and the technology powerful enough to make use of it is owned by millions of
people, often in the palms of their hands.
The arrival of powerful smartphones and computers with built-in video capabilities means that you
don't have to wait for the AR effects as you do with TV. They can simply be overlaid onto real
life. Step forward Apple's iPhone, and phones using Google's Android operating system, both of
which are capable of overlaying information on top of a picture or video.
Within the small world of AR, one of the best-known apps is that built by Layar, which – given a location, and
using the iPhone 3GS's inbuilt compass to work out the direction you're pointing the phone
– can give you a "radar map" of details such as Wikipedia information, Flickr
photos, Google searches and YouTube videos superimposed onto a picture you've taken of the scene.
For Americans, it will also pull in details from the government's economic Recovery Act
– so that if you're on Wall Street and want to see how many billions went into
which building, it will show you.
Or, more usefully, Yelp offers an augmented reality
application that will show you ratings and reviews for a restaurant before you walk in
– the sort of thing that could make restaurants quiver with delight, or
shudder in horror.
Or maybe it wouldn't need to know where it is; only who it's looking at. A prototype application
demonstrated at the Mobile World Congress in Barcelona in February took things a little further
again. Point the phone at a person and if it can find their details, it will pull them off the
web and attach details – their Twitter username, Facebook page and other facts
– and stick them, rather weirdly, into the air around their head (viewed
through your phone, of course). "It's taking social networking to the next level," says Dan
Gärdenfors, head of user experience research at The Astonishing Tribe, a Swedish mobile software company.
And there are fabulously useful applications: at Columbia University, computer science professor
Steve Feiner and PhD candidate Steve Henderson have created their Augmented Reality for
Maintenance and Repair (Armar) project. It combines sensors, head-up displays, and
instructions to tackle the military's maintenance needs: start working on a piece of kit, and the
details about it pop up in front of
you. Imagine if you could put on a pair of special goggles when you needed to investigate
your car's engine, or a computer's innards, and the detail would pop up. That's the sort of idea
that Armar is trying to implement, though for the military at first..
Yet it's fashion which seems to have leapt quickest into this technology. The T-shirt with AR in
London Fashion Week was developed by Cassette Playa, a label that has been worn by Lily Allen,
Rihanna and Kanye West. Carri Munden, who designed it with the Fashion Digital Studio at the
London College of Fashion, described it as "mixing reality and fantasy". Adidas, too, has
launched trainers with AR symbols in the tongues: hold them to a webcam and you are taken to
interactive games on the Adidas site.
The process by which the strange symbols get translated into images is simple enough: the website
takes the feed from your webcam (you have to explicitly allow it to do so, so there are no
security worries) and analyses it for the particular set of symbols that the program is looking
for. (Some easy calculations mean the symbols can be detected whichever way up you hold the
item.) Videos and pictures are then sent back to you.
Andy Cameron says that the arrival of an open-source, hence free, AR tool kit has let companies
build their own AR applications, using Flash – the pervasive animation and
video technology used for many online ads and YouTube's videos – "which
immediately meant you had huge penetration, because Flash is everywhere". (Something like 98% of
all computers are reckoned to have Adobe's Flash Player installed.)
"If you build your AR application with Flash, then you can get it out to everybody in the world
with a computer with a webcam," says Cameron.
Benetton is using AR in its latest campaign, called "It's My Time" which aims to get members of the public to put themselves forward as
potential models, and uses AR to show more details about existing models. But its first most
visible use of AR was last year in issue 76 of Benetton's Colors magazine, a quarterly
fashion product. Dozens of pages have AR symbols: hold the page up to a webcam, and you see film
and more photos of the person on the page. "The Colors editor and the creative director
of Fabrica got very excited about it," says Cameron.
Cameron can see huge potential which could even revive the fortunes of print advertising. "Think
of a commercial page, an advert, in a fashion magazine. It's pretty expensive. With this
– and this is the way that the more hard-nosed people in Benetton saw the
advantage – it means that you can get more products on the page." Print an AR
code, get people to come to the site, and you can show them so much more, while measuring the
return from your effort.
The technical cost is a tiny part of the overall effort. "The printing and photography cost [of
the advert] is the same. And the development cost is pretty small."
And of course where advertisers go, the publications that house them are sure to go as well.
Esquire magazine in the US and Wallpaper* in Europe have done "augmented
reality" editions, with Robert Downey Jr coming to life on the cover of the former, and AR text
providing videos and animation in the latter. But there are more possibilities for journalism
using AR: for example if you "geotag" newspaper articles (so that you say that an item relates to
a particular place) then someone visiting a site could learn about events relevant to the area
via their smartphone.
Book publishers too are leaping in: Carlton Publishing will release an AR book in May, featuring
dinosaurs that pop out of the pages when viewed, yes, through a webcam. Future releases include
war, sport and arts titles which will also have extra AR elements.
Yet in media it's the advertisers who are most excited. The possibilities of geotagged, targeted
adverts – which in effect hang in the air until someone comes along to find
them with a smartphone – or of AR adverts which open up a whole new world of
opportunities (and perhaps discounts or loyalty bonuses) when you follow them through
– are yet another glimpse of the holy grail ofads that know exactly who and
where you are.
Is there a risk that we'll all become AR'd out – that it will become boring as
advert after advert invites us to hold it up to a webcam? "What's hot today is ancient history
tomorrow," says Cameron. "There have been a lot of bad uses of this technology with a rush to use
it. We have had the chance to reflect on what it means and how to use it. The key is that it
should be an enhancement of the stuff on the printed page."
Even so we're still in the early stages, he argues. "It's very primitive –
having to use a webcam, holding a magazine up to it. Obviously we're really interested in the
opportunities with handheld devices. It's very frustrating that the iPhone doesn't allow access
to the live video stream." (Nor does it run Flash, another problem for would-be AR designers.)
"People in design are very annoyed with Steve Jobs," he observes. "We don't really understand why
Apple won't allow that."
Given that access, he says, "you could hold your iPhone up to a billboard and get something
amazing right there". What about the alternative, such as Google's Android-based Nexus phone? "It
looks like you could do it on that," he says. But of course the iPhone is a target market. "Maybe
Apple wants to keep that for itself," Cameron says. "Maybe they're lodging patents. Or maybe the
processor on the iPhone isn't fast enough."
Yet there are some who think that AR has already had its brief time in the sun. At the Like Minds
conference in Exeter at the beginning of March, Joanne Jacobs, a social media consultant,
described an AR application that demanded you buy a T-shirt and then go and sit in front of your
webcam – so you could play Rock, Paper, Scissors. By yourself.
"It's hopeless," Jacobs said.
Cameron admits to some uncertainty about AR's measurable impact. "I don't know if it sells more
things, but it seems clearly a good thing if we can get people who may be customers to
participate in the adverts." But, he adds: "If people start to play with the adverts in a way
that exposes them to more products, that's got to help bring a commercial return."
Charles Arthurguardian.co.uk © Guardian News & Media Limited 2010 | Use
of this content is subject to our Terms & Conditions | More Feeds

|
BBC News | News Front Page | World Edition -
22 hours and 49 minutes ago
Liverpool boss Rafael Benitez is targeting a Champions League place rather than stopping Manchester
United's quest for a 19th league title ahead of Sunday's meeting.
|
BBC News | News Front Page | UK Edition -
22 hours and 49 minutes ago
Liverpool boss Rafael Benitez is targeting a Champions League place rather than stopping Manchester
United's quest for a 19th league title ahead of Sunday's meeting.
|
TechCrunch -
1 days and 7 hours ago
When I
came to the U.S. in 1980, I was young and naïve. I used to think that corruption and ethical
lapses were just a third-world ill. Eventually, I became a tech CEO and learned the harsh
realities of American business. Yes, standards are much higher, and breaches are punished, but
the temptations are just the same here as they are in any other country. Ethical lapses (which
are a form of corruption) are quite common. You watch stories about these on TV
every other day and read about them on TechCrunch. It was the ethical lapses of our
financial institutions that threw our economy into a tailspin, and for which we are paying the
price, after all.
It is best to be aware of the temptations and to prevent the lapses from occurring. As Enron,
Bernie Madoff, and Lehman
Brothers have shown, it’s a slippery slope. Once you start compromising your values for
short-term gains, there is no turning back. Business ethics are not something you need to start
worrying about when your company reaches a certain size; they need to be sewn into the fabric of
your startup from the get-go. The lessons are the same for tech businesses as they are for
investment banks and for third-world economies.
Harvard Business School professor Michael Beer
researched the difference between companies that perform at high levels for extended periods and
those that implode when they reach a certain size. When analyzing the spectacular failures in the
recent financial meltdown, he found that:
· Of the original Forbes 100 (named in 1917), 61 had ceased to exist by 1987.
 Of the remaining 39, only 18 stayed in the top 100, and their return during the
period 1917 to 1987 was 20% less than that of the overall market.
· Of companies in the original Standard & Poor’s 500-stock index of 1957, only
74 remained in 1997; of these, only 12 outperformed the S&P 500 in the period 1957 to 1998.
· The average CEO tenure in the U.S. is 4.2 years, less than half the 10.5-year average in
1990.
Beer posited three core reasons for the failure of so many Wall Street firms in the fall of 2008:
the firms lacked a higher purpose (in other words, they were focused on short-term gains,
profits, and bonuses); they lacked a clear strategy; and they mismanaged their risk. Companies
like Charles Schwab and US Bancorp were able to avoid the fallout by having a laser-like focus on
customer service and on honesty and transparency. Neither company touched the subprime mortgage
securitization market, because they saw it as risky and simply not the kind of business that
served the company’s long-term interests.
Even outside Wall Street, companies like Cisco Systems, Southwest Airlines, and Costco Wholesale,
with the strongest sense of higher purpose, achieved the greatest success. Take Costco. Wall
Street analysts have long chastised Costco’s management for paying high wages and keeping
employees around for a long time, because this results in higher benefits costs. But the
company’s CEO, Jim Sinegal, lives by his belief that keeping good employees is strategic
for Costco’s long-term success and growth. The company’s per-employee sales are
considerably higher than those of key rivals such as Target and Wal-Mart; customer service at the
stores is phenomenal and fast; and Costco continues to expand, both in number of warehouses and
in products and services for business and consumer customers. The culture of the company flows
downward from Sinegal and his focus on employees and, by extension, to customers.
One of the problems that Beer found with the failed banks was that their employees lacked the
ability to “speak truth to power”. Employees felt intimidated by superiors; the
institutions’ internal voice of conscience and purpose was silenced by a maniacal focus on
short-term profits and whatever scheme would bring them in. The silencing of employees who sought
to challenge strategy and risk-management practices likely also undermined the banks’ moral
authority and emboldened those who already felt inclined to do the wrong thing. With a muted
internal voice, these organizations lacked a moral compass. As a result, they drove off a cliff
with astonishing speed.
The same things happen in Silicon Valley companies. Â I asked
management guru — and head of the CEO
Institute of Yale School of Management — Jeff Sonnenfeld for his advice on how
startups can sow the seeds for building a Cisco or Costco. Here is Jeff’s advice:
1)Â Create a culture of openness and welcome dissent
– Internal constructive critics are your best friends — too
often, founders are blinded by their own enthusiasm for their creative vision and then are
surrounded by sycophants, kissing up. Founders who fall out of touch rapidly lose their ethical
bearings. At Intel, founder Robert Noyce and Gordon Moore did not look for sycophantic followers
in selecting the brilliant, contentious, but relentlessly honest Andy Grove as their colleague
and successor. Similarly, Craig Barrett and Paul Otellini have consistently fought for different
points of view internally — without undermining the enterprise, and always
reinforcing Intel’s self-critical core ethic.
2)Â Lead by example. Â The authenticity of the
leader’s character is essential — if colleagues don’t believe you,
they will not take needed risks on your behalf — such as training subordinates
to be able to do their own jobs. Â Startups are often defined by the hip
clichés of VC firms, adoring press, and HR consultants — but the
startups don’t really practice what they preach.
3)Â Learn from immediate peers or distant models. Too often,
founders atrophy because they believe that the unique quality of their business or technological
mission means that they too are truly unique in leadership values. Steve Jobs has
patterned himself after Polaroid founder Ed Land — and tried to learn from
Land’s strengths and weaknesses. Henry Ford regretfully once claimed
“History is bunk” but in reality revered Thomas Edison. Michael Dell put
legendary tech entrepreneur (Teledyne) and educator Dr. George Kozmetsky on his board right from
the start to learn from this brilliant then septuagenarian.
4)Â Recognize your own fallibility as a leader, know your limits, and beware
of the myth of immortality. Entrepreneurs often are horrified at the
thought of leadership succession. The founders of great firms such as Google, Cisco, Amgen, and
Microsoft have known that they would need to prepare for a day when they no longer could be the
lone day-to-day internal boss, primary external ambassador, and symbolic cultural icon. The
founder of the original (pre-Starbucks) coffee house chain Chock-Full-o-Nuts started his first
café on Broadway 43rd Street in 1923 and was a great national
success. Sadly, sixty years later, as a dying man who had been flat on his back for
two years at Massachusetts General Hospital in Boston, he still clung to the job of leader of the
enterprise, his full-time physician serving as acting president.
5) Remember that institutional character — like a liquid
cupped in your hand — is fragile; easily lost; and hard, if not impossible, to
regain. Egomaniacal moves, personal grandiosity, greed, and deception create impressions
that are hard to erase. Whole Foods founder, John Mackey, sabotaged the integrity of
his own exalted brand, damaging the company’s internal pride and customer admiration far
more badly than any competitor could have, due to his self-inflating and his misleading
“anonymous” blogging, hiding his identity through an anagram of his wife’s
name, “rehodab.”
I’ll add another very important point: Establish an independent board.
Venture firms often demand a majority of board seats as a condition for their investments.
Conflicts invariably arise. The board begins to serve the needs of VCs and management, rather
than of the company itself, which loses the independent voice to warn it not to do the wrong
things. The inconvenient truth is that all board members have a fiduciary duty to act in the
interests of the company, and not in their own interests. Board members must not engage in
transactions in which they or their partners stand to gain. They are legally required to avoid
these conflicts of interest.
Finally, remember that in business, you have to make tough choices at every juncture. Though
business decisions usually have clear consequences and outcomes, ethical decisions are always
hard. Making the right choice doesn’t always bring success, but ethical lapses almost
always lead to failure. No matter what the consequence, doing what’s ethical and right is
always the better long-term strategy.
Editor’s note: Guest writer Vivek Wadhwa is an entrepreneur turned
academic. He is a Visiting Scholar at UC-Berkeley, Senior Research Associate at Harvard Law
School and Director of Research at the Center for Entrepreneurship and Research Commercialization
at Duke University. Follow him on Twitter at @vwadhwa.


|
CrunchGear -
1 days and 7 hours ago
 Woof.
Analysts have placed a sell rating on Palm and are now
valuing their stock, at least in hyperbolic terms, at $0. Quoth CNN: Shares of Palm
(PALM) plunged 19% to $4.59 a share early Friday, a new 52-week low. Investors are becoming
increasingly pessimistic about the company's future and several analysts downgraded their positions
on the stock to "sell." Two analysts even lowered their price targets to $0.

|
CiteULike: Borelli's watchlist -
1 days and 9 hours ago
Sensors and Actuators B: Chemical, Vol. 143, No. 2. (07 January 2010), pp. 740-749.
An electronic nose (EN) based on an array of chemiresistors, combined with a preconcentrator unit,
for the detection of some volatile organic vapors was developed. In order to choose the proper
polymers, seven potential polymers were chosen from numerous available polymers according to the
principle of the linear solvation energy relationship (LSER). Different possible sensors arrays
(128 arrays) composed of these seven polymers were designed by full factorial design (FFD).
Principal component analysis (PCA) showed that four of seven polymers had enough ability to
recognize different gas classes. By using Hierarchical cluster analysis (HCA), the tested polymers
were categorized into four main groups with respect to their recognition ability. Combination of
the FFD with PCA and HCA, brought to the identification of 8 proper arrays containing four polymers
in each array. Precisely evaluation of predicted arrays with respect to their calculated resolution
factors showed that the electronic nose containing the polymers of 75% pheny125% methylpolysiloxane
(OV25), hexafluoro-2-propanolsubstituted polysiloxane (SXFA), poly bis(cyanopropyl)-siloxane (SXCN)
and poly(ethylene maleate) (PEM) was the most proper design for recognition of analytes of
interest. The fabricated EN was used successively for target gas recognition at three different
concentrations.
Taher Alizadeh

|
Planet Ubuntu -
1 days and 12 hours ago
Picking up where Fagan left off on the Quickly ubuntu-application tutorial, I'm writing a
ubuntu-pygame tutorial using docbook format. The last time I tried available XML editors, the ones
I found were crashy, or didn't offer much above and beyond Gedit, so I ended up editing XML in
Gedit.
I tried again in Lucid, and found XML Copy-Editor in software-center. I love it! I'm getting
statement completion for the schema currently in use (see screenshot above), and error highlighting
when I make mistakes. It's also fast and rock solid on my mini 10v!
Interesting that it's built in wxWidgets. I wonder if they target this to be Cross
Platform? 
|
eve-online.com | devBlog -
1 days and 12 hours ago
No, we’re not hiring the Hanson brothers to deal with RMT threats. As
there is no one better at beating up targets than EVE pilots, we thought we'd enlist your talents
in slapping EVE Gate into shape.
As CCP t0rfifrans
outlined on his blog introducing Tyrannis, we will
be delivering the very first iteration of EVE Gate in the upcoming expansion. It is my task to
oversee the technical direction of the Web side of things with EVE Gate, and I wanted to take the
opportunity to announce a public “Alpha” test we are planning for EVE Gate and the
steps we are taking to make sure we have a very sound foundation to build upon. What we don't
want to do is just turn all the traffic completely on the first day and pray it doesn’t
break under load. Instead we plan a measured approach that will make sure we have a solid
architecture and enough hardware in place.
The process we are following is as follows:
- Develop and prototype an N-Tier web application with scalability in mind from day one (See my
first
blog on "Cosmos" ) - DONE
- Release and stress an internal alpha to identify and address weakspots - DONE
- Build and utilize load testing and application profiling tools to find and fix bottlenecks -
DONE
- Release a public "alpha" stress test to apply real world load to the application to check our
hardware needs against estimates and monitor it under real conditions
- Roll out a "beta" launch
- Ramp up to full access in increments
On March 23, we will announce access to a public stress test version of EVE Gate which will be
connected to Singularity for all of you to log into and look around. What is critical for
everyone to understand is that the intent of this test is to stress the underlying hardware and
key architectural components. This will allow us to identify and address bottlenecks and
weaknesses well before launch and to make sure we have adequate hardware in place for all the
pounding you folks will put on it once you are all browsing EVE Gate routinely from work (when
your boss isn't looking). We will be watching your comments closely for feedback as well as
closely logging and monitoring the behavior of the software and hardware under load. You can help
us out greatly just by logging in, browsing around and trying the application out.
It needs to be emphasized that while it gives you an early glimpse at EVE Gate, the primary
purpose of this test is a technical one. The features included in the test are still heavily in
development and we wanted to get an early version up and available for you to beat up the
hardware well in advance. There will be elements that are not yet done or which are presented as
a simplified version for testing purposes. To make this clear the application will be labeled the
"EVE Gate Alpha Stress Test"; it will be pretty hard to miss. I am not going to go into depth
here on the features that will be included; we have an additional Dev Blog that will be presented
soon which will focus on the web based functionality which will come with EVE Gate at launch
(calendar, mail, contacts, profiles, broadcast logs, etc).
When EVE Gate does go live with the expansion it will be released as a Beta launch. It will be
fully functional and connected to Tranquility for access to production data however it will be a
Web site that we will continually modify and enhance. As it is a Web site, we have the benefit of
not being tied directly to client releases and can continue to upgrade the site as quickly as we
can get improvements completed. Once access is fully ramped up and we are comfortable that it is
fully stable and production ready we’ll rip off the Beta stamp.
When I mention an incremental ramp up to full access, what I am describing is a measured increase
in the number of players that can access the site when the Beta version goes live. We will do
this with a basic signup page on launch day and we will give X number of additional players
access each day depending on how things are going. Rather than turning the faucet fully on we are
going to open it up a bit, check that all is well, open it up a bit more, etc… until we
have it fully open and everyone has access.
Obviously we will open it up as quickly as is feasible as we have a lot more features we want to
get to work on (>cough< forums >cough<) but our emphasis is on doing this the right
way. Hopefully the ramp up will be quick, and this "Alpha" test I have announced here will play a
big part in getting us as much information as possible so we can be ready. The better the info we
get out of the "Alpha," the more accurate our hardware setup will be, the quicker we can ramp up
full access when we go live.
The team is really looking forward to rolling out EVE Gate for you to use, and we will have
greater detail on the features it will include in a future Dev Blog.

|
How to of the Day -
1 days and 13 hours ago
A finished "Trap" targetHere's an easy way to make a cardboard Airsoft target that traps your
pellets.
|
CiteULike: Borelli's watchlist -
1 days and 18 hours ago
Growth Hormone & IGF Research, Vol. 11 (June 2001), pp. S1-S8.
Summary In all biological systems, the information content of hormonal signals is conveyed by the
modalities ofpulsatile hormone secretion. New mathematical tools for the analysis of pulsatile
behaviour and increasing knowledge of the sources of signal variability have enabled us to
recognize altered hormonal pulsatility associated with human disease. Its consequences for our
understanding of disease mechanisms, for diagnostic procedures and for therapeutic decisions are
discussed at the level of single hormones. Increased disorderliness of hormone secretion is a
hallmark of pituitary adenomas, indicating functional subsystem autonomy. The effects on target
tissues of changing growth hormone therapy from low-frequency administration to long-acting
preparations are still incompletely understood. In contrast, the gonadotropic axis is a paradigm
for the successful therapeutic use of induced pulsatility changes, where therapy with long-acting
gonadotropin-releasing hormone (GnRH) agonists suppresses endogenous gonadotropin pulses and
gonadal function, and pulsatile GnRH administration is used to restore normal gonadal function.
Future development of endocrine therapies will depend on our knowledge of hormonal pulsatility.
B Hauffa

|
Techmeme -
1 days and 18 hours ago
Blake Ellis / CNNMoney.com:
Palm's new
price target: $0 — NEW YORK (CNNMoney.com) — Palm's future
already looked bleak. But after reporting worse than expected results for the third quarter
Thursday, some analysts think the company's stock is now essentially worthless.
— Shares of Palm (PALM) plunged 19% to $4.59 a share early Friday, a new 52-week low.
|
Journal of Neuroscience -
1 days and 19 hours ago
Publication Date: 2010 Mar 17 PMID: 20237283Authors: Pang, Z. P. - Cao, P. - Xu, W. - Sudhof, T.
C.Journal: J NeurosciCalmodulin regulates multifarious cellular processes via a panoply of target
interactions. However, the central role, multiple isoforms, and complex target interactions of
calmodulin make it difficult to examine its precise functions. Here, we analyzed calmodulin
function in neurons using lentivirally delivered short-hairpin RNAs that suppressed expression of
all calmodulin isoforms by approximately 70%. Calmodulin knockdown did not significantly alter
neuronal survival or synapse formation but depressed spontaneous neuronal network activity.
Strikingly, calmodulin knockdown decreased the presynaptic release probability almost twofold,
without altering the presynaptic readily-releasable vesicle pool or postsynaptic neurotransmitter
reception. In calmodulin knockdown neurons, presynaptic release was restored to wild-type levels by
expression of constitutively active calmodulin-dependent kinase-IIalpha (CaMKIIalpha); in contrast,
in control neurons, expression of constitutively active CaMKIIalpha had no effect on presynaptic
release. Viewed together, these data suggest that calmodulin performs a major function in boosting
synaptic strength via direct activation of presynaptic calmodulin-dependent kinase II.post to:
CiteULike

|
Media Matters for America -
1 days and 21 hours ago
You know those special
amps used by Spinal Tap that go to 11, in order to provide "that extra push over the cliff"?
It appears Fox News has gotten a hold of some and hooked them up to its coverage of health care
reform.
As the reform bill moved closer to a vote in the House, the Fox News noise machine went into
overdrive, hurling every false and misleading claim it could muster.
The week in Fox News health care hysteria began with an oldie-but-goodie -- Steve Doocy, Bill Hemmer, and Bill O'Reilly all claimed or suggested that
the bill will, in O'Reilly's words, "require American taxpayers to fund abortion." But it
doesn't, at least not beyond what is currently permitted under current law. Fox News,
unfortunately, is not alone in
repeating this falsehood.
Then, Doocy and Hemmer, joined by Neil Cavuto and several other hosts, jumped on the idea that
a legislative procedure the House is reportedly considering to pass the Senate's version of
health care reform would allow them to do so without a vote. Wrong again -- the House would need
to vote to implement that procedure.
Carl Cameron, however, broke through the noise on this issue, pointing out that the process would simply
pass the bill "in one vote instead of two" and that the process "has been used, literally, for
centuries" -- indeed, Republicans made
copious use of the "self-executing rule" when they controlled Congress. Even Charles
Krauthammer conceded that it's
constitutional. Still, that didn't keep Alisyn Camerota from scoffing that the rule "might as well be a
self-immolating rule."
Fox News then pounced on a survey
claiming to have found that 46 percent of primary care physicians would consider leaving their
profession if health care reform passes. O'Reilly, Sean Hannity, and contributor Dr. Marc Siegel
all portrayed the survey as having been published by the prestigious New England Journal of
Medicine.
Except it wasn't. The article was written by the physician-recruiting firm that conducted the
survey, and it actually appeared in an employment newsletter produced by the publisher of the
New England Journal of Medicine, not the Journal itself. Further, the survey
itself was not all that scientific -- done via email contacts taken from the recruiting firm's
database -- so any claim that the survey's results accurately reflect the view of the American
medical community is dubious at best.
Fox News' Megyn Kelly did eventually note
that the survey was "not a scientific poll." But that didn't keep Glenn Beck from insisting -- hours after Kelly corrected the
record -- that "The New England Journal of Medicine says that if this bill is
passed nearly one-third of doctors will quit practice medicine."
(Beck, meanwhile, is keeping up the long
tradition of Fox News hosts pushing partisan political agendas by joining with Republican
Rep. Steve King to promote an anti-reform rally in Washington.)
Fox News contributor and serial
misleader Dana Perino made her own non-contribution to the health care debate, asserting that the reform bill's Medicare
investment tax on those making over $200,000 a year is "so disturbing ... because the people who
make that money are the small business owners." In fact, fewer than 1.3 percent of small business
owners would be affected by the tax.
When the Congressional Budget Office released new numbers detailing how the reform bill would
reduce the deficit by $130 billion over 10 years, Fox News didn't want to talk about that -- it
spent far more time highlighting how
much the bill would cost instead of how much it would save. And when that didn't seem to work, it
tried to discredit the CBO as
untrustworthy and unreliable. Never mind that when the CBO issued "favorable" numbers last fall
on a Republican health care reform plan, Fox News praised the CBO as "nonpartisan."
The Fox News spin is even confusing its own hosts. Brian Kilmeade can't quite comprehend how a bill can cost money
yet reduce the deficit, and Kelly admitted, "I don't understand anything they're
talking about when it comes to this potential law."
Fox News' inept war against health care reform, while in keeping with its function as the
communications arm of the Republican
Party in exile, is making itself look like the Spinal Tap of news. It doesn't really need that
"extra push over the cliff" -- after all, that's what it's been speeding toward for years.
At this rate, it probably won't be too long before a Fox anchor
spontaneously combusts.
Other stories this week
A whole lot of shaky earthquake claims goin' on at Fox
How much does Fox News oppose health care reform? It's pretending natural disasters didn't happen
if they're inconvenient to the anti-reform agenda.
On March 18, Doocy took exception to
President Obama's statement that a provision in the health care reform that would help Louisiana
cope with Medicaid shortfalls resulting from Hurricane Katrina might also help Hawaii because it
"went through an earthquake. "Hold it. What Hawaiian earthquake?" Doocy asked. "There was an
earthquake in 1868 that killed 77. There was an earthquake in 1975 that killed two." After noting
that the provision applies to states that have suffered a natural disaster "within the last seven
fiscal years," Doocy added: "Essentially it boils down to just one state, and that is Louisiana."
Doocy seems to have forgotten that there was an
earthquake in Hawaii in 2006. Not only did it cause tens of millions of dollars in damage,
the
Bush administration "declared a major disaster exists in the State of Hawaii and ordered
Federal aid to supplement State and local recovery efforts" as a result of the quake.
But Doocy didn't need to rely on federal agencies for information on the quake -- Fox News
reported on it at the time.
(Investor's Business Daily similarly
ignored its own reporting to suggest there was no recent Hawaii quake.)
It seems that rather than trust the federal government or his own news organization, Doocy chose
instead to trust right-wing bloggers, who were spreading the misinformation. That runs
counter to a 2007
memo -- issued after Doocy and other Fox hosts falsely claimed that Obama was educated in a
madrassa -- in which Fox News vice president John Moody reportedly wrote, "For the record: seeing
an item on a website does not mean it is right. Nor does it mean it is ready for air on FNC."
Media Matters has written
Fox News requesting that Doocy correct the record. We shouldn't have to, since Fox News is
supposed to have a "zero tolerance" policy toward on-air mistakes, but then, these are the same
folks that
ludicrously insisted that a Fox & Friends graphic in which poll numbers added up to 120 percent contained no
errors.
The latest right-wing witch-hunt target: Jim Wallis
Fox News has long been a leader in witch hunts against Obama and his administration (or, really,
anyone who can be remotely tagged as liberal). Now Glenn Beck, as an extension of his repeated
challenged Beck to a debate over
social justice, Beck demurred, his vaguely
threatening statements making it clear his witch hunt was more important than reasoned
debate: "In my time, I will respond. ... Just know the hammer's coming. ... And when the hammer
comes, it's going to be hammering hard and all through the night, over and over."
Right-wing website WorldNetDaily, meanwhile, blundered into the breach with a poorly written
article that attempted to put words in Wallis' mouth. WND claimed that Wallis was a "champion of
communism," even though Wallis has declared communism to be a "failed" system; asserted that
Sojourners has published "a slew of radicals" while ignoring that it has also published a slew of
conservatives; and alleged that "Sojourners' official 'statement of faith' urges readers to
'refuse to accept [capitalist] structures and assumptions that normalize poverty and segregate
the world by class,' " even though the word "capitalist" -- inserted by WND -- actually appears
nowhere in the statement. WND even falsely claimed that Wallis "labeled the U.S.
'the great captor and destroyer of human life.' "
Somehow, we suspect that Beck's upcoming assault on Wallis will be just as divorced from reality
as WorldNetDaily's.
Erick Erickson joins the "scumbags" at CNN
Should a blogger who once called a retiring Supreme Court justice a "goat f---ing child molester"
be rewarded with a regular commentary gig on CNN? Doesn't matter -- the deal's been done.
CNN announced this week that RedState editor Erick Erickson has joined the network as a political
contributor, mainly appearing on John King's new show. The network claimed that Erickson is "a
perfect fit" for King's show, adding that "Erick is in touch with the very people John hopes to
reach."
Media Matters has detailed
Erickson's history of outrageous statements, of which the aforementioned is but one.
Predictably, conservatives defended
Erickson's new job, his fellow RedStaters among them. One of Erickson's RedState defenders,
however, went a tad off-message: "From
Non-Conservatives, to Academics and Liberal Elitists, to self-soiling and unprincipled
Professional Politicians and firmly-entrenched good ole boys inside the
M(ostly) S(cumbags)
M(edia), each of these clowns has a tale of doom about the
hell we're headed for compliments of CNN's hand basket."
We have to wonder: Does Erickson consider
his new CNN colleagues to be "scumbags"?
This week's media columns
This week's media columns from the Media Matters senior fellows: Eric Boehlert
examines the media myth of Obama's
"falling poll numbers," and Karl Frisch tells you how to annoy Glenn Beck in five minutes or
less.
Facebook, Twitter, YouTube, MySpace, and Digg
Media Matters maintains active online communities on the nation's leading
social networking sites. Be sure to join us on Facebook, Twitter, YouTube,
MySpace,
and
Digg and join in on the discussion.
Media Matters Minute now on
YouTube
For some time now, radio shows and stations throughout the country have been carrying the
Media Matters Minute, a daily, minute-long recap of our work topped off with
the "most outrageous comment" of the day. We encourage you to subscribe (YouTube /
iTunes /RSS) to the
Minute's daily podcast, hosted by Media Matters' Ben Fishel.
This weekly wrap-up was compiled and edited by Terry Krepel, a senior web editor at Media
Matters for America.


|
Mashable! -
1 days and 23 hours ago
Kevin Nakao is VP of Mobile & Business Search for
WhitePages, a Top 40 Web and Mobile
Publisher. You can find him on Twitter,
and on the Whitepages
Blog where he writes about mobile, local, and social media.
While last year’s SXSW seemed to serve as the
“coming out” party for location-based services (LBS), maybe this year’s
conference signifies the migration of these platforms into mainstream culture. And perhaps the
only real “new” concept to emerge this year is the idea that there is finally a real
opportunity to make money via “location.”
Here are five things that companies should consider as they look to utilize location-based
services (LBS) as part their mobile strategy.
1. Location Shouldn’t be the Only Goal
From finding the nearest ski slope on REI’s Ski and Snow Report to a nearby movie on Flixter, there are
plenty of Top iPhone applications that have incorporated a “lead with the offer, not the
capability” philosophy into their mobile product offering to provide a better service.
Build the best service first, then add the bells and whistles.
With all the hoopla surrounding location, it is easy to lose sight of the fact that
location’s real appeal to advertisers is the fact that with this functionality, you can
reach the on-the-go user, who is ready to buy and consume. Just because Twitter and Facebook offer location doesn’t make
that valuable or new to advertisers. Location-targeting via IP address has been around a while.
For the same reason radio is a great advertising channel for retailers, LBS advertising is also
valuable: because it can reach the consumer near the point of sale.
2. The “Long Tail” for User Adoption
Foursquare has clearly emerged as the location
darling. Consider the fact that after only one year, they’ve reached 500,000
active users (Foursquare recently tweeted they added 100,000 users in 10 days).
However, if you apply any city’s share of the total U.S. population, the results show some
pretty low estimates of Foursquare users in individual localities. What emerges is a very
“long tail” — a steep, narrow graph — of local user adoption. This shows
why it is important to achieve scale if you hope to see return on investment in the location
marketing space.
For example, using these rough estimates of a city’s proportional share of the U.S. population, if a
local pet supply store wanted to target people in San Francisco, the estimated reach would be
1,310 Foursquare users. Even if you double this audience estimate, the number is fairly small for
even a local marketer. We had to hit around 4 million downloads of the Whitepages iPhone app to
achieve the minimum scale needed for advertiser geo-targeting. Today, 80% of our campaigns from
major brands are geo-targeted.
Editor’s Note: It’s important to remember that these are just rough estimates.
Because Foursquare was initially only available in a handful of major metro areas, the geographic
distribution of users may not precisely follow the geographic distribution of the
population.
3. Mobile Battery Life is Key
Battery life is the single biggest threat to location. With GPS on, the phone is asking the
network where it is, and this chatter can drain battery life — anyone with an iPhone knows what I am referring to. Thus, phone
manufacturers will play a critical role in the future of LBS. RIM, the manufacturer of BlackBerry devices, faced this problem early on with
the energy-tax of e-mail polling, and as a result, their devices now have some of the best
battery life.
Foursquare has helped us move forward here as well. “Check-ins” help to address the
issue as they offer efficient geo-triggers without having to keep battery-draining GPS features
on at all times.
4. Location Will Be the Battleground of the Mobile OS
Looking forward, I predict the mobile platform wars will be fought with location and maps. This
is an important feature that a platform can use as a point of differentiation for consumers and
developers.
In anticipation of that battle, Apple purchased mapping company Placebase, and Google is starting to provide unique
mapping features like turn-by-turn navigation on
its Android devices. The only hope I see for
Windows Mobile is if they do something
completely revolutionary on the mobile location front. A development like this was alluded to at
the recent TED conference with its augmented reality
layering of geo-tagged Flickr photos and real-time
video integration.
5. Location Pays
At WhitePages, we monetize our mobile services through a mix of premium, national display, and
sponsored links for local business. Our effective CPM (revenue per thousand ad impressions) for
sponsored local links is $30-$50 — double the effective CPM (eCPM) rate we see for premium
display ad campaigns from national brands. The eCPM multiple of local targeted ads over ad
network rates is a staggering 10x.
Location-based inventory will also become scarce as Apple recently
announced that iPhone apps will not be permitted to access GPS capabilities for advertising
alone. There now needs to be some consumer benefit and functionality in order to access a
user’s location. Geo-targeted inventory on mobile will continue to be at a high premium
with no excess supply or ad networks to drive it down.
Conclusion
It is my hope that by this time next year, SXSW –- the festival of
“emerging” music and technology –- will have finally moved on from
location. It’s clearly happening now, and if integrated wisely, location will be making
companies too much money to be called the “cool kid on the block” any longer
More location-based resources from Mashable:
- 9 Killer Tips for
Location-Based Marketing
- 10 Foursquare Apps You Can Use
Right Now
- 6 Foursquare Apps We’d Love to
See
- 6 Tips for Getting the Most out of
Foursquare
- Foursquare vs. Gowalla:
Location-Based Throwdown
- Location, Location,
Location: 5 Big Predictions for 2010
Tags: android, business, foursquare, geo-tagging, gowalla, iphone, List,
Lists, location based advertising, location-based, Longtail, MARKETING, Mobile 2.0, small business


|
Electronista | Gadgets for Geeks -
2 days ago
 Palm was delivered harsh criticism today as analysts downgraded the company
following its poor fiscal performance. Canaccord Adams' Peter Misek maintained a "sell" opinion but
called for a price target of $0 as he expected the company's situation would only get worse. He
predicted a vicious circle that would see carriers and part producers back out with doubts about
Palm's ability to stay in business, hurting its ability to sell devices even more....
|
GameSetWatch -
2 days and 1 hours ago
[‘Design Diversions’ is a biweekly GameSetWatch-exclusive column
by Andrew Vanden Bossche. It looks at the unexpected moments when games take us behind the
scenes, and the details of how game design engages us. This time -- how emotional design can make
us think about not thinking about violence.]
Senseless violence in videogames is fun, but more importantly, it can also be intellectually
stimulating and thought provoking. While designers and critics alike cry out for more depth in
games, pathos is not the only path to artistic merit. For a medium that's constantly patronized,
misunderstood, and derided even by its supporters, sometimes satire and irony is the best way to
get a point across.
This is the philosophy of Grand Theft Auto: Vice City, as
the most unapologetic of that series so lambasted by those who were the target of the
game’s satire. The ultraviolent and candy colored Vice City is an excessively pink world in
which violence is comical and cartoonish. Violence in this game is already highly desensitized.
Pedestrians die, but after their bodies despawn the world will be back to normal as if nothing
happened, maintaining the status quo like a TV serial.
It's the worst possible environment for a serious engagement with issues of violence, but it's a
great environment to engage with how we depict violence. Most games take the opposite position of
Haunting Ground, and are designed to soften, justify, or excuse violent actions so that players
feel like heroes instead of murderers.
It's the same treatment summer blockbusters get. But unlike most of these media, Vice City goes a
step further. This is a game that mercilessly skewers the groups most opposed to its existence,
freely leaps into self parody, and satirizes the cultural attitudes towards violence that
ultimately gave it form. By the end of Vice City it's clear that everyone from the mob to the
talking heads on the radio are guilty of the same violence as the protagonist. No one in Vice
City is innocent, and neither is anyone in the world.
How to Take the Sense Out of Violence
While technology makes blood and gore more realistic, game designers continue to construct this
violence to minimize its impact. In the goriest of games (like Mortal Kombat) violence is there
to thrill or disgust, not to inspire existential terror. Designers (and gamers) get excited over
realism, but we want it for specific reasons. Despite how much we clamor for realism in graphics
and physics, emotional realism actually gets in the way of enjoying games like Grand Theft Auto.
For this reason GTA4 has actually been criticized for being too realistic. GTA4 succeeded in its
attempt to be more serious and taken more seriously, but it resulted in a different game
experience--one that many fans hadn't been looking for and subsequently found in the much less
serious Saints Row 2.
GTA4’s Nico feels more like a person than the caricature that is Vice City’s Tommy
Vercetti, and for that reason it can be hard for players to engage senseless violence. Even the
normal missions feel a little odd considering the sheer number of people you kill, creating a
scenario in which the gameplay and story don’t quite mesh.
Abstracting Emotion
Trauma Center is an interesting example of a game that uses abstraction to eliminate
squeamishness. This is a game inspired heavily by medical dramas with surgery-based gameplay.
Medical dramas have a wide appeal; exposed organs do not. Surgeons and other medical
professionals have to get used to blood and guts, but most people are pretty squeamish about
that. Even the bloody fantasy violence of the average videogame can be less intense than the
exposed entrails of a living human. Because of this, the designers went to great lengths to
create a representation of the human body that wouldn't be grotesque.
Naoya Maeda, the lead 3D and event designer said on the Trauma Team web site that he came up with
this abstract approach while thinking of how a surgeon would see the entrails. What's interesting
about this approach is that the more realistic option may be less "true." In the game, the player
is a doctor and revulsion is not part of the experience. In the same way, Tommy Vercetti attitude
towards human life is pretty obvious from the way pedestrians are depicted.
A World of Mannequins
In violent videogames, it’s common to dehumanize the enemy so that players can feel
justified in killing them. Zombies, robots, and aliens all serve their roles. With human
opponents, it’s common to make them as evil as possible, which may be why WWII is the
favorite FPS genre and Nazis the favorite foe. Ultimately though, the greatest tool for removing
humanity is simply to leave them undeveloped.
The civilians in GTA don’t mourn, cry, or express themselves. Because they don't exhibit
sympathetic actions, it's hard to empathize with them. They exist only to run screaming like
Godzilla was stomping through the city. Vice City is inhabited by crash test dummies that respawn
endlessly no matter how many times they die. It’s similar to watching Bugs Bunny gets
blasted point blank with a shotgun: the next second, he's up and chomping carrots.
No matter how many times the player dies in GTA, or however many generic citizens he wastes,
everything in the world will be respawning and back to normal in minutes. In this way, actions
that would normally appear reprehensible loose all their emotional impact. If GTA was an accurate
murder simulator, depicting the horror of real-world violence and murder with unflinching
accuracy, the nightly news stories would have been about kids getting PTSD.
Sensitive Violence
If there is a flaw in this form of violence in videogames, it’s that it isn’t violent
enough. It’s emotionally casual, designed specifically to not challenge the player’s
feelings of empathy or guilt. Although it takes a lot of design work to make sure the player
won’t feel sorry for the extras, seeing how many pixilated crash-test dummies you can run
over isn’t emotionally challenging for the player.
Haunting Ground has a near-opposite outcome, but the design is obviously quite intentional.
Compare GTA to the visceral Manhunt, and you can see that Rockstar is quite capable of creating
an experience uniquely tailored to inspiring certain emotions. That’s a game that really
does make the player feel like a murderer.
So Vice City is engineered for players to be as violent as possible without thinking about it.
This is where a lot of game stop, having accomplished their purpose, and just let the player have
fun. But Vice City fills the game with relentless satire, and this cleverness works in part
because it's so violent. The result is a game about thinking about not thinking about violence.
Whose America?
The talk radio blabbering about videogame violence is underscored by the incredible violence
perpetuated by the player. With Tommy Vercetti chaining rows of exploding cars and fighting
everything from SWAT to the US Army, the irony of legislating against bleeding pixels isn’t
lost on the player.
The jingoistic ads run by the game's gun stores unsubtly implicate that GTA is not the cause of
America's attitudes towards violence, but a product of it. The entrepreneurial rise of the main
character reflects a certain pulling-yourself-up-by-your-bootstraps-attitude that, along with
this construction of violence, satirically constructs Tommy Vercetti as an ideal American.
Vice City is violent videogame about America’s attitude towards violence. Vice City came
out after GTA 3, and it was born while the immediate reaction to that game was fresh in the minds
of its audience and opponents. As the in game talk show parody unfolds, extremists from all sides
fight over which vision of America to cram down the rest of the country’s throat while the
player is laughing at them and having a grand old time.
While the guests on talk radio worry about fictional violence, their world is being blown up by
the player on a regular basis. After mowing down the city in a tank, players may wonder why they
aren't the ones being discussed on the news. Shouldn't they be thinking about real violence?
Shouldn't the player? It's fun to live the American Dream as Tommy Vercetti, but is this bitter
satire worth bringing to reality?
Even though Vice City goes to great lengths to create emotionally uninvolved violence, it wants
the player to be conscious of how different this is from real world violence. At the time, the
charge levied against the playerbase and the industry was that videogames confused the two. With
the pitch perfect satire of radio pundits and activists, Vice City invites the player to think
about whether the game is more damaging to society than the people trying to ban it. Rockstar has
a clear agenda, of course, and stacks the deck in their favor. Even so, that’s a lot to
think about for a game that’s not supposed to be about thinking at all.
Pathos certainly has its place in videogames, and it's certainly something we need more of. A GTA
like game that forced players to confront the realities of murder would be an interesting idea.
It couldn't work as a satire, and it wouldn't really be fun, but that’s just fine as
it’s another way to engage the player. One of the great things about survival horror games
like Haunting Ground is that they've proven that games don't necessarily need to be fun to be
compelling.
But let's not underestimate Vice City just because it makes us laugh.
[Andrew Vanden Bossche is a freelance writer and student. He has a blog called Mammon Machine, which is updated less often than this
message, and can be reached at AndrewVandenB@gmail.com]


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Engadget -
2 days and 1 hours ago

Remember that
wild January day a bit over a year ago, when Palm debuted webOS and shares went wild?
Well, after months of setbacks in the sales arena, and a rough
$22 million Q3 loss announced yesterday, Palm's stocks took over a 25 percent dive today,
dipping below $5 for the first time since the Pre was announced. At the time of this writing things
seem to be leveling off a bit, but it's the most damage the shares have seen since October of 2009.
Morgan Joseph analyst Ilya Grozovsky has downgraded the stock to "sell" and set a target price at
$0. Canaccord Adams analyst Peter Misek has set a similar target, saying that he sees a "complete
lack of earnings visibility." So, candlelit vigil time? Imminent buyout? Riots in the streets?
Hardly. Palm's own Jon Rubinstein said in the earnings announcement that the company is "looking
forward to upcoming launches with new carrier partners" which should (hopefully) brighten spirits a
bit, and we haven't heard a single credible buyout rumor, despite plenty of wild conjecture. There
are also still a pair of analyst hold outs (just two, to be exact) that have buy ratings on the
stock, reports Thomson Reuters. As for rioting? Well, that's up to you. No matter what,
Palm has some serious soul searching to do.
Palm shares take 25 percent plunge after downer earnings announcement originally appeared on
Engadget on Fri, 19 Mar 2010 14:59:00 EST. Please see our
terms for use of feeds.
Permalink | Wall
Street Journal | Email this | Comments

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MacNN | The Macintosh News Network -
2 days and 1 hours ago
 Palm was delivered harsh criticism today as analysts downgraded the company
following its poor fiscal performance. Canaccord Adams' Peter Misek maintained a "sell" opinion but
called for a price target of $0 as he expected the company's situation would only get worse. He
predicted a vicious circle that would see carriers and part producers back out with doubts about
Palm's ability to stay in business, hurting its ability to sell devices even more....

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InfoWorld: Top News -
2 days and 1 hours ago
Palm is reporting dramatically lower sales of its WebOS-based smartphones. It seems the
once-dominant maker of PDAs has nowhere to go but down and its plummeting fast, making it a
potential target for acquisition by a smartphone competitor.
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LinuxDevices.com -
2 days and 1 hours ago
A Berlin-based software company is preparing an Intel Atom N450-based e-reader that runs Linux with
Android extensions. Billed as the & tablet PC for publishing houses,& Neofonie GmbH's &
WePad& tablet sports an 11.6-inch touchscreen, 16GB of flash storage, a SD card, WiFi,
Bluetooth, USB, and a webcam, says Neofonie....
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The Boy Genius Report -
2 days and 3 hours ago
Palm’s woes continue to balloon after the handset maker announced its earnings for Q3 2010.
As a recap, Palm reported $349 million in revenue with a $22 million net loss for Q3 2010 which
looks rosy when compared to the $90.6 million revenue and $98 million net loss reported in Q3
2009. Though revenue has increased and net loss has narrowed year over year, Palm continues its
downward slide with net loss increasing from $13.7 million in Q2 2010 to the $22 million quoted
above. Palm shipped 960,000 handsets in Q3 2010 which represents a 23% increase from Q2 2010 and
a 300% increase year over year. This abundance of handsets is Palm’s downfall as the
handset maker revealed that it has only sold a mere 408,000 units in Q3 2010, leading to a
standing inventory that some estimate to be a staggering 1.15 million. Palm has put handset
production on hold (told
you so) while carriers sell through the current inventory which is equal to six months worth
of retail sales at last year’s rate. As a result, Palm’s Q4 2010 outlook is dire with
the company projecting revenue of only $150 million, a figure that falls far short of the $305
million that was expected. Read on after the jump.
Palm’s stock has plummeted a staggering 18% to under $5 since its poor Q3 2010 earnings and
its dire Q4 projections were announced. Like a pack wolves, analysts are jumping all over the
Sunnyvale, California company, issuing stock price targets as low as $0. Peter Misek of Canaccord
Adams, who issued the $0 value, defends his pessimistic view of Palm by writing,
“We believe Palm’s troubles will only accelerate as carriers and suppliers
increasingly question the company’s solvency and withdraw their support.With what appears
to be roughly 12 months of cash on hand, an accelerating burn rate, a complete lack of earnings
visibility, and substantial debt and preferred equity, we no longer see any value in the
company’s common equity.”
Palm is at the edge of a precipice and needs either a miracle or a very wealthy suitor to save it
from what appears to be inevitable self destruction. Anyone with a Pre or Pixi in good condition
may want to box that puppy up and put it in a drawer as it may be a collector’s item
someday. We’re half kidding. Kind of.
Read (Q3 2010 earnings)
Read (Inventory)
Read
(Worthless stock)


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